Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein Rx and R3 to R5 are as described herein: or pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), or pharmaceutically acceptable salts thereof, wherein X, m, n, and R1 to R3 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3 and n are as defined herein, compositions including methods of making the compounds and using the compounds as ATX inhibitors.

Abstract: The invention provides novel compounds having the general formula I wherein R1, R2, and R3 are as defined herein, compositions including the compounds and methods of using the compounds.

Abstract: A bearing assembly for a charging apparatus. The bearing assembly comprises a bearing housing and a shaft. The bearing assembly further comprises a compressor-side bearing bushing and a turbine-side bearing bushing which together support the shaft inside a bearing bore of the bearing housing. The bearing assembly is configured to supply unequal amounts of lubricant to a compressor-side outer lubrication gap of the compressor-side bearing bushing and to a turbine-side outer lubrication gap of the turbine-side bearing bushing. The bearing assembly is further configured to supply unequal amounts of lubricant to a compressor-side inner lubrication gap of the compressor-side bearing bushing and to a turbine-side inner lubrication gap of the turbine-side bearing bushing.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: A bearing assembly for a charging apparatus. The bearing assembly comprises a bearing housing and a shaft. The bearing assembly further comprises a compressor-side bearing bushing and a turbine-side bearing bushing which together support the shaft inside a bearing bore of the bearing housing. The compressor-side bearing bushing is configured differently than the turbine-side bearing bushing.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R14 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: Provided are novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R4, m, n, and p are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: The invention provides new bicyclic heteroaryl compounds having the general formula (I) wherein R1, R2, R3, R4, A, X, n and m are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Abstract: The disclosure provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X1, RA and R3 to R7 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: A bearing assembly for a charging apparatus. The bearing assembly comprises a bearing housing and a shaft. The bearing assembly further comprises a compressor-side bearing bushing and a turbine-side bearing bushing which together support the shaft inside a bearing bore of the bearing housing. The compressor-side bearing bushing is configured differently than the turbine-side bearing bushing.

Abstract: A bearing assembly for a charging apparatus. The bearing assembly comprises a bearing housing and a shaft. The bearing assembly further comprises a compressor-side bearing bushing and a turbine-side bearing bushing which together support the shaft inside a bearing bore of the bearing housing. The bearing assembly is configured to supply unequal amounts of lubricant to a compressor-side outer lubrication gap of the compressor-side bearing bushing and to a turbine-side outer lubrication gap of the turbine-side bearing bushing. The bearing assembly is further configured to supply unequal amounts of lubricant to a compressor-side inner lubrication gap of the compressor-side bearing bushing and to a turbine-side inner lubrication gap of the turbine-side bearing bushing.

Abstract: The disclosure provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X1, RA and R3 to R7 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: A computer-implemented method for synchronizing a first data object to a second data object, wherein, each data object is assigned to a metaclass from a number of metaclasses, the metaclasses being organized in a tree structure with a root metaclass; a metaclass in the tree structure is ascertained that is situated on the path between the first data object and the root metaclass and on the path between the second data object and the root metaclass, a first and a second metaobject are produced from the ascertained metaclass; two transformations are performed to transform the first data object into the first metaobject and the second data object into the second metaobject; the first metaobject and the second metaobject are synchronized; and a third transformation is performed, the first metaobject being transformed into the first data object and the second metaobject being transformed into the second data object.

Abstract: A computer-implemented method and a correspondingly adapted computer program product or software application for connecting business objects in a software application (SA), wherein the software application comprises a connector (K), wherein the connector comprises a code identifying an abstract business object class (ABO1 to ABOn), the software application identifies the abstract business object class specified in the connector at runtime in a hierarchy of abstract business object classes, and the software application, at runtime, proceeding from the identified abstract business object class, identifies at least one concrete business object class (KBO1 to KBOn), directly or indirectly derived therefrom, and establishes a connection (V) in at least one instance (I1 to In) of the at least one identified concrete business object class, via which connection the software application accesses attributes and methods of the instance of the concrete business object class.

Abstract: Disclosed are a method and a system for accessing data by a client device in a distributed network system having a central server system, at least one client device, and at least one business object server. The client device and business object server are coupled to the central server system via a communication network. In the business object server, a number of business objects are stored. Each business object server includes a number of offices; each business object is assigned to an office in the respective business object server. The central server system receives an access request message, which includes at least one unique client identifier; the central server system determines at least one access authorization by means of the client identifier, and generates access instructions for the business objects, which the client device is allowed to access. The business objects are read and are transmitted to the client device.