Abstract: The invention relates to a compound of formula (I) wherein A1, A2, A3, R1, R2, R2?, R3, R4 and R5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract: Systems and methods for directing an alert to responders are provided. Upon activation of an alert application on a user device, an options screen is displayed to a user. The user can select a report option, and a screen is displayed for the user to enter information into one or more required and optional fields regarding a threat or a risk event. Once the system determines that the required fields have been filled, the system automatically composes a customized alert message based on the received information, automatically determines appropriate responders to notify. The customized alert message is transmitted to the determined responders, and acknowledgement messages are received from the responders.

Abstract: The disclosure relates to a method for obtaining information on the status of a motor vehicle during a production process of the motor vehicle by means of a monitoring system, having the steps of: providing a motor vehicle blank during the production process, said motor vehicle blank having at least one required emergency call control apparatus; generating the information on the motor vehicle status by means of the emergency call control apparatus within the motor vehicle; and transmitting the information to the monitoring system by means of the emergency call control apparatus.

Abstract: Systems and methods for directing an alert to responders are provided. Upon activation of an alert application on a user device, an options screen is displayed to a user. The user can select a report option, and a screen is displayed for the user to enter information into one or more required and optional fields regarding a threat or a risk event. Once the system determines that the required fields have been filled, the system automatically composes a customized alert message based on the received information, automatically determines appropriate responders to notify. The customized alert message is transmitted to the determined responders, and acknowledgement messages are received from the responders.

Abstract: A wet multi-plate clutch includes a plate carrier with a pair of fluid passage openings and a friction plate rotationally fixed and axially displaceable relative to the plate carrier. The friction plate has a carrier element and a pair friction pads fastened to the carrier element and delimiting a groove. The groove includes a groove geometrical center line. The groove geometrical center line may extend radially through a one of the pair of fluid passage openings, or it may extend radially between the pair of fluid passage openings. If the groove geometrical center line extend radially between the pair of fluid passage openings, one of the pair of friction pads may include a pad geometrical center line extending along a radial extent through a one of the pair of fluid passage openings.

Abstract: A method for load management of a charging station, in which the charging station is formed by at least two charging points, each with a charging control and a power electronics module assigned to the respective charging point, a charge management server and a transformer connected to an electricity supply network. The network provides a transformer power, in which the load management carried out by the load management server controls an allocation of the transformer power among the respective charging points, in which a respective charging operation of a particular electric vehicle at a particular charging point is controlled via the respective charging control connected to the load management. Charging power controlled by the load management is provided by the respective power electronics module assigned to the respective charging point. The load management has a dynamic and a static execution mode.

Abstract: To control movement of a transport unit of a linear motor, a quality functional J(SG) with quality terms JTk(SG) is used as a function of manipulated variables (SG) of active drive coils. The quality functional J(SG) controlling movement of the transport unit along the stator is optimized with regard to the manipulated variable (SG) to determine optimal manipulated variables (SGopt) for the relevant time step of the control of movement, active drive coils are energized according to the determined optimal manipulated variables (SGopt), and at least two movement phases are provided during the movement of the transport unit along the stator. In the at least two movement phases, different quality functionals J(SG) are used for determining the optimal manipulated variables (SGopt), the different quality functionals J(SG) differing by the number k of the quality terms JTk(SG) used and/or by the quality terms JTk(SG) and/or by the weighting Factors kk.

Abstract: The invention relates to administration systems and to methods which can improve the safety of administration systems, more particularly the safety of an infusion system, in which system it is checked, when the medication container is exchanged, whether the new container is appropriate for the system. A system of this type consists of an administration device (1), a mobile communication device (3) and servers (5). When a reservoir (2) or the administration device (1) is replaced, an image of information (2a) is captured by means of a camera (3a) of the communication device (3). As a result of evaluation of the information (2a) by means of a software application, functions of the administration device (1) are activated or not.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4 and R5 are as defined herein, compositions including the compounds and methods of using the compounds.

Abstract: The invention provides novel compounds having the general formula (1) wherein R1, R2, R3, R3b, R4, A1, A2, A3, A4, A5, A6, B1, B2, B3, B4, and L are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein Rx and R3 to R5 are as described herein: or pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), or pharmaceutically acceptable salts thereof, wherein X, m, n, and R1 to R3 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3 and n are as defined herein, compositions including methods of making the compounds and using the compounds as ATX inhibitors.

Abstract: The invention provides novel compounds having the general formula I wherein R1, R2, and R3 are as defined herein, compositions including the compounds and methods of using the compounds.

Abstract: A bearing assembly for a charging apparatus. The bearing assembly comprises a bearing housing and a shaft. The bearing assembly further comprises a compressor-side bearing bushing and a turbine-side bearing bushing which together support the shaft inside a bearing bore of the bearing housing. The bearing assembly is configured to supply unequal amounts of lubricant to a compressor-side outer lubrication gap of the compressor-side bearing bushing and to a turbine-side outer lubrication gap of the turbine-side bearing bushing. The bearing assembly is further configured to supply unequal amounts of lubricant to a compressor-side inner lubrication gap of the compressor-side bearing bushing and to a turbine-side inner lubrication gap of the turbine-side bearing bushing.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: A bearing assembly for a charging apparatus. The bearing assembly comprises a bearing housing and a shaft. The bearing assembly further comprises a compressor-side bearing bushing and a turbine-side bearing bushing which together support the shaft inside a bearing bore of the bearing housing. The compressor-side bearing bushing is configured differently than the turbine-side bearing bushing.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R14 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.