Abstract: A sealing ring, including at least one sealing element having a first permeation coefficient, and at least one permeation barrier of a thermoplastic material having a second permeation coefficient, wherein the at least one sealing element and the at least one permeation barrier form a unit, and wherein the first permeation coefficient is higher than the second permeation coefficient.

Abstract: To control movement of a transport unit of a linear motor, a quality functional J(SG) with quality terms JTk(SG) is used as a function of manipulated variables (SG) of active drive coils. The quality functional J(SG) controlling movement of the transport unit along the stator is optimized with regard to the manipulated variable (SG) to determine optimal manipulated variables (SGopt) for the relevant time step of the control of movement, active drive coils are energized according to the determined optimal manipulated variables (SGopt), and at least two movement phases are provided during the movement of the transport unit along the stator. In the at least two movement phases, different quality functionals J(SG) are used for determining the optimal manipulated variables (SGopt), the different quality functionals J(SG) differing by the number k of the quality terms JTk(SG) used and/or by the quality terms JTk(SG) and/or by the weighting Factors kk.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4 and R5 are as defined herein, compositions including the compounds and methods of using the compounds.

Abstract: The invention relates to administration systems and to methods which can improve the safety of administration systems, more particularly the safety of an infusion system, in which system it is checked, when the medication container is exchanged, whether the new container is appropriate for the system. A system of this type consists of an administration device (1), a mobile communication device (3) and servers (5). When a reservoir (2) or the administration device (1) is replaced, an image of information (2a) is captured by means of a camera (3a) of the communication device (3). As a result of evaluation of the information (2a) by means of a software application, functions of the administration device (1) are activated or not.

Abstract: The invention provides novel compounds having the general formula (1) wherein R1, R2, R3, R3b, R4, A1, A2, A3, A4, A5, A6, B1, B2, B3, B4, and L are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), or pharmaceutically acceptable salts thereof, wherein X, m, n, and R1 to R3 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein Rx and R3 to R5 are as described herein: or pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3 and n are as defined herein, compositions including methods of making the compounds and using the compounds as ATX inhibitors.

Abstract: The invention provides novel compounds having the general formula I wherein R1, R2, and R3 are as defined herein, compositions including the compounds and methods of using the compounds.

Abstract: A bearing assembly for a charging apparatus. The bearing assembly comprises a bearing housing and a shaft. The bearing assembly further comprises a compressor-side bearing bushing and a turbine-side bearing bushing which together support the shaft inside a bearing bore of the bearing housing. The bearing assembly is configured to supply unequal amounts of lubricant to a compressor-side outer lubrication gap of the compressor-side bearing bushing and to a turbine-side outer lubrication gap of the turbine-side bearing bushing. The bearing assembly is further configured to supply unequal amounts of lubricant to a compressor-side inner lubrication gap of the compressor-side bearing bushing and to a turbine-side inner lubrication gap of the turbine-side bearing bushing.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: A bearing assembly for a charging apparatus. The bearing assembly comprises a bearing housing and a shaft. The bearing assembly further comprises a compressor-side bearing bushing and a turbine-side bearing bushing which together support the shaft inside a bearing bore of the bearing housing. The compressor-side bearing bushing is configured differently than the turbine-side bearing bushing.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R14 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: Provided are novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R4, m, n, and p are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: The invention provides new bicyclic heteroaryl compounds having the general formula (I) wherein R1, R2, R3, R4, A, X, n and m are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Abstract: The disclosure provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X1, RA and R3 to R7 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: A bearing assembly for a charging apparatus. The bearing assembly comprises a bearing housing and a shaft. The bearing assembly further comprises a compressor-side bearing bushing and a turbine-side bearing bushing which together support the shaft inside a bearing bore of the bearing housing. The compressor-side bearing bushing is configured differently than the turbine-side bearing bushing.