Patents by Inventor Christian Kulinna

Christian Kulinna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing amino crotonyl compounds
    Patent number: 8426586
    Abstract: An improved process for preparing 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline and related aminocrotonyl compounds and the preparation of a suitable salt of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline for use as a pharmaceutically active substance.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: April 23, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Rainer Soyka, Werner Rall, Juergen Schnaubelt, Peter Sieger, Christian Kulinna
  • SALT FORMS OF A 6-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE DERIVATIVE, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
    Publication number: 20110130437
    Abstract: The present invention relates to salt forms of the compound 4-[(Z)-[[4-[(dimethylaminoJmethyllphenyllaminolCe-fluoro-1,2-dihydro2-oxo-3H-indol-3-ylidene)methyl]-benzenepropanoic acid which are suitable for pharmaceutical development and to a process for their manufacture.
    Type: Application
    Filed: January 22, 2009
    Publication date: June 2, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Ulrike Werthmann, Christian Kulinna, Waldemar Pfrengle, Werner Rall
  • Process for preparing amino crotonyl compounds
    Publication number: 20070027170
    Abstract: An improved process for preparing 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline and related aminocrotonyl compounds and the preparation of a suitable salt of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline for use as a pharmaceutically active substance.
    Type: Application
    Filed: July 14, 2006
    Publication date: February 1, 2007
    Inventors: Rainer Soyka, Werner Rall, Juergen Schnaubelt, Peter Sieger, Christian Kulinna
  • Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
    Patent number: 6908928
    Abstract: Crystalline monohydrate of (1?,2?,4?,5?,7?)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof, and their use.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: June 21, 2005
    Assignee: BI Pharma KG.
    Inventors: Rolf Banholzer, Peter Sieger, Christian Kulinna, Michael Trunk, Manfred Graulich, Peter Specht, Helmut Meissner, Andreas Mathes
  • Process for preparing amino crotonyl compounds
    Publication number: 20050085495
    Abstract: The invention relates to an improved process for preparing 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylam ino)-1 -oxo-2-buten-1 -yl]am ino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline and related aminocrotonyl compounds and the preparation of a suitable salt of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1 -oxo-2-buten-1 -yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline for use as a pharmaceutically active substance.
    Type: Application
    Filed: September 15, 2004
    Publication date: April 21, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Rainer Soyka, Werner Rall, Juergen Schnaubelt, Peter Sieger, Christian Kulinna
  • Powder formulations containing tiotropium suitable for inhalation
    Patent number: 6881422
    Abstract: A method of making a physically stable and homogenous powdered pharmaceutical composition comprising a tiotropium salt and a physiologically acceptable excipient, the method comprising: (a) suspending the tiotropium salt and the physiologically acceptable excipient in a suspending agent in which the tiotropium salt and the physiologically acceptable excipient are essentially insoluble to obtain a suspension; and (b) removing the suspending agent from the suspension of step (a) to obtain the pharmaceutical composition, the pharmaceutical composition itself, and method of treating respiratory diseases, especially chronic obstructive pulmonary disease and asthma, in a patient in need thereof by administering an effective amount of the pharmaceutical composition to the patient.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: April 19, 2005
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Manfred Graulich, Christian Kulinna, Andreas Mathes, Helmut Meissner, Peter Seiger, Peter Specht, Michael Josef Friedrich Trunk
  • Powder formulations containing tiotropium suitable for inhalation
    Publication number: 20050009857
    Abstract: A method of making a physically stable and homogenous powdered pharmaceutical composition comprising a tiotropium salt and a physiologically acceptable excipient, the method comprising: (a) suspending the tiotropium salt and the physiologically acceptable excipient in a suspending agent in which the tiotropium salt and the physiologically acceptable excipient are essentially insoluble to obtain a suspension; and (b) removing the suspending agent from the suspension of step (a) to obtain the pharmaceutical composition, the pharmaceutical composition itself, and method of treating respiratory diseases, especially chronic obstructive pulmonary disease and asthma, in a patient in need thereof by administering an effective amount of the pharmaceutical composition to the patient.
    Type: Application
    Filed: July 27, 2004
    Publication date: January 13, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Manfred Graulich, Christian Kulinna, Andreas Mathes, Helmut Meissner, Peter Sieger, Peter Specht, Michael Trunk
  • Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
    Patent number: 6777423
    Abstract: Crystalline monohydrate of (1&agr;,2&bgr;,4&bgr;,5&agr;,7&bgr;)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof, and their use.
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: August 17, 2004
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Rolf Banholzer, Peter Sieger, Christian Kulinna, Michael Trunk, Manfred Graulich, Peter Specht, Helmut Meissner, Andreas Mathes
  • Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
    Publication number: 20040087793
    Abstract: Crystalline monohydrate of (1&agr;,2&bgr;,4&bgr;,5&agr;,7&bgr;)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof, and their use.
    Type: Application
    Filed: October 23, 2003
    Publication date: May 6, 2004
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Rolf Banholzer, Peter Sieger, Christian Kulinna, Michael Trunk, Manfred Graulich, Peter Specht, Helmut Meissner, Andreas Mathes
  • Powder formulations containing tiotropium suitable for inhalation
    Publication number: 20040029907
    Abstract: A method of making a physically stable and homogenous powdered pharmaceutical composition comprising a tiotropium salt and a physiologically acceptable excipient, the method comprising:
    Type: Application
    Filed: April 3, 2003
    Publication date: February 12, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Manfred Graulich, Christian Kulinna, Andreas Mathes, Helmut Meissner, Peter Sieger, Peter Specht, Michael Josef Friedrich Trunk
  • Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
    Publication number: 20030171586
    Abstract: Crystalline monohydrate of (1&agr;,2&bgr;,4&bgr;,5&agr;,7&bgr;)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof, and their use.
    Type: Application
    Filed: January 30, 2003
    Publication date: September 11, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Rolf Banholzer, Peter Sieger, Christian Kulinna, Michael Trunk, Manfred Graulich, Peter Specht, Helmut Meissner, Andreas Mathes
  • Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
    Publication number: 20020169321
    Abstract: Crystalline monohydrate of (1&agr;,2&bgr;,4&bgr;,5&agr;,7&bgr;)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof, and their use.
    Type: Application
    Filed: September 24, 2001
    Publication date: November 14, 2002
    Inventors: Rolf Banholzer, Peter Sieger, Christian Kulinna, Michael Trunk, Manfred Graulich, Peter Specht, Helmut Meissner