Abstract: A method for the low-temperature separation of air using an air separation plant which comprises a rectification column arrangement (10) having a pressure column, a low-pressure column and an argon column, wherein: the low-pressure column comprises a first and a second rectification region (A, B); the argon column comprises a first and a second rectification region (C, D, D1, D2); argon-enriched fluid is removed from the low-pressure column between the first and second rectification region (A, B) thereof and is fed into the first rectification region (C) of the argon column; and argon-depleted fluid is removed from the first rectification region (C) of the argon column (13a, 13b) and is fed into the low-pressure column between the first and second rectification region (A, B) thereof.

Abstract: This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Abstract: The invention relates to a method for a low-temperature air separation in which an air separation unit is used comprising a first rectification column and a second rectification column. The first rectification column is operated at a first pressure level, and the second rectification column is operated at a second pressure level below the first pressure level. Fluid which is oxygen-enriched compared to atmospheric air is drawn from the first rectification column in the form of one or more first material flows. At least one fraction of the fluid which has been drawn from the first rectification column in the form of the one or more first material flows is heated in a heat exchanger; a fraction of the fluid which has been heated in the heat exchanger is compressed using a compressor and is returned to the first rectification column.

Abstract: This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates comprising antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The application also discloses methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Abstract: The invention relates to a method for a low-temperature air separation in which an air separation unit is used comprising a first rectification column and a second rectification column. The first rectification column is operated at a first pressure level, and the second rectification column is operated at a second pressure level below the first pressure level. Fluid which is oxygen-enriched compared to atmospheric air is drawn from the first rectification column in the form of one or more first material flows. At least one fraction of the fluid which has been drawn from the first rectification column in the form of the one or more first material flows is heated in a heat exchanger; a fraction of the fluid which has been heated in the heat exchanger is compressed using a compressor and is returned to the first rectification column.

Abstract: A band saw machine has two deflection pulleys arranged one above the other in the vertical direction, an endless saw band, which is guided around the deflection pulleys and which has an upward running portion and a downward running portion, and a machine frame, which has a saw neck for holding at least the upper deflection pulley. The deflection pulleys are arranged substantially parallel to a front edge of the machine frame, so that both the upward running portion and the downward running portion of the saw band face towards the front edge with their cutting edges. The saw neck is arranged offset from the deflection pulleys from the front edge (6) to the rear. Both the upward running portion and the downward running portion of the saw band are at least partially exposed between the deflection pulleys.

Abstract: A band saw machine has two deflection pulleys arranged one above the other in the vertical direction, an endless saw band, which is guided around the deflection pulleys and which has an upward running portion and a downward running portion, and a machine frame, which has a saw neck for holding at least the upper deflection pulley. The deflection pulleys are arranged substantially parallel to a front edge of the machine frame, so that both the upward running portion and the downward running portion of the saw band face towards the front edge with their cutting edges. The saw neck is arranged offset from the deflection pulleys from the front edge (6) to the rear. Both the upward running portion and the downward running portion of the saw band are at least partially exposed between the deflection pulleys.

Abstract: The present invention relates to antibodies or fragments thereof that target a conformational epitope of a HER receptor. In particular, the invention relates to antibodies or fragments thereof that target a conformational epitope of HER3 receptor and compositions and methods of use thereof.

Abstract: The present invention relates to antibodies or fragments thereof that target a conformational epitope of a HER receptor. In particular, the invention relates to antibodies or fragments thereof that target a conformational epitope of HER3 receptor and compositions and methods of use thereof.

Abstract: The present invention relates to antibodies or fragments thereof that target a conformational epitope of a HER receptor. In particular, the invention relates to antibodies or fragments thereof that target a conformational epitope of HER3 receptor and compositions and methods of use thereof.

Abstract: The process and the device are used to produce a pressurized gaseous product by low-temperature separation of air in a distillation system, which has at least one high-pressure column (7) and one low-pressure column (8). A process air stream is compressed in a main air compressor. At least a part of the compressed process air stream (1) is introduced (6) into the high-pressure column (7). A first air stream (10, 13, 14, 17, 18), which is formed at least by a part of the process air stream (1), is compressed to a high air pressure (11, 15), which is at least 1 bar above the operating pressure of the high-pressure column (7). A liquid product stream (21, 47) is removed from the distillation system, brought (48, 51) to an elevated pressure in the liquid state, and evaporated or pseudo-evaporated with the first air stream (17) under this elevated pressure by indirect heat exchange (4), and finally drawn off as a gaseous product stream (50, 53).

Abstract: The invention relates to a process for recovering argon by low-temperature separation of air. Rectifying system (2, 4) exhibits at least one air separation column (4), which has a partition (5) that runs in lengthwise direction of the column, by which air separation column (4) is separated at the level of partition (5) into a first subsection and a second subsection (6, 7). A fluid (3) that contains oxygen and argon is introduced into first subsection (6). A stream (13) that contains oxygen and argon with an argon concentration of between 15% and 50% is removed in second subsection (7).

Abstract: A process and apparatus for low-temperature fractionation of air in a distillation column system for nitrogen-oxygen separation (5, 6) introduces into first feed air stream (4) into a distillation column system for nitrogen-oxygen separation. An oxygen-rich fraction (22) from the distillation column system for nitrogen-oxygen separation is pressurized (23) in liquid form and is added (25) to a mixing column (26). A heat transfer medium stream is introduced into the lower region of the mixing column (26) and is brought into countercurrent contact with the oxygen-rich fraction (22, 25). Gaseous top product (260) from the upper region of the mixing column (26) is introduced into an additional column (27). A liquid (38, 39, 40, 41) from the lower or middle region of the mixing column is introduced into the distillation column system.

Abstract: A process and apparatus for low-temperature fractionation of air in a distillation column system for nitrogen-oxygen separation (5, 6) introduces into first feed air stream (4) into a distillation column system for nitrogen-oxygen separation. An oxygen-rich fraction (22) from the distillation column system for nitrogen-oxygen separation is pressurized (23) in liquid form and is added (25) to a mixing column (26). A heat transfer medium stream is introduced into the lower region of the mixing column (26) and is brought into countercurrent contact with the oxygen-rich fraction (22, 25). Gaseous top product (260) from the upper region of the mixing column (26) is introduced into an additional column (27). A liquid (38, 39, 40, 41) from the lower or middle region of the mixing column is introduced into the distillation column system.

Abstract: The process and device are used to obtain a compressed product by low temperature separation of air in a rectification system which has a pressure column and a low pressure column. A first flow of compressed and purified feedstock air is cooled in a main heat exchanger system and is fed into the pressure column. At least one fraction from the pressure column is expanded and fed into the low pressure column. An oxygen-rich fraction from the low pressure column is liquid-pressurized and delivered to a mixing column. A heat exchange medium is fed into the lower area of the mixing column and is brought into countercurrent contact with the oxygen-rich fraction. A gaseous top product is removed from the upper area of the mixing column. A product fraction is removed from the rectification system, liquid-pressurized, vaporized in indirect heat exchange with the gaseous top product of the mixing column and is withdrawn as the compressed product.

Abstract: The process and the apparatus serve for separating a gas mixture in a separation plant. A feed gas (18) is introduced into a compressor system (6, 16) and then into the separation plant. In the event of loss or partial loss of the compressor system (6, 16) of the first feed gas compressor (6), a first auxiliary stream (91, 92) which has approximately the composition of the first product stream or approximately the composition of the feed gas is compressed (78, 89) to at least approximately the first pressure and is recirculated to the separation plant.

Abstract: The process and device are used to obtain a compressed product by low temperature separation of air in a rectification system which has a pressure column and a low pressure column. A first flow of compressed and purified feedstock air is cooled in a main heat exchanger system and is fed into the pressure column. At least one fraction from the pressure column is expanded and fed into the low pressure column. An oxygen-rich fraction from the low pressure column is liquid-pressurized and delivered to a mixing column. A heat exchange medium is fed into the lower area of the mixing column and is brought into countercurrent contact with the oxygen-rich fraction. A gaseous top product is removed from the upper area of the mixing column. A product fraction is removed from the rectification system, liquid-pressurized, vaporized in indirect heat exchange with the gaseous top product of the mixing column and is withdrawn as the compressed product.

Abstract: The process and the apparatus serve for separating a gas mixture in a separation plant. A feed gas (18) is introduced into a compressor system (6, 16) and then into the separation plant. In the event of loss or partial loss of the compressor system (6, 16) of the first feed gas compressor (6), a first auxiliary stream (91, 92) which has approximately the composition of the first product stream or approximately the composition of the feed gas is compressed (78, 89) to at least approximately the first pressure and is recirculated to the separation plant.

Abstract: In a single column distillation system for obtaining gaseous and liquid nitrogen with a variable proportions of liquid product by low-temperature separation from air, a first portion (12, 13) of nitrogen-rich fraction (5, 7, 8) is fed downstream of circulation compressor (9) to the liquefaction chamber of a condenser-evaporator (14) associated with the single column and condensed under a pressure higher than the operating pressure of the single column (4). A liquid oxygen-enriched fraction (228, 231) from the distillation column system is at least partially evaporated in the evaporation chamber of condenser-evaporator (14). A portion (18) of nitrogen-rich liquid (15, 16) from condenser-evaporator (14) is drawn off at least at times as liquid product. A second oxygen-enriched gas (221, 521) is removed from one of columns (546) of the distillation system and/or from the evaporation chamber of condenser-evaporator (14), machine expanded(23), and heated in main heat exchanger (2).

Abstract: For obtaining gaseous nitrogen by low-temperature separation from air, a distillation column system has a single column (4). Compressed air (1) is cooled in a main heat exchanger (2) and fed (3) to single column (4). A nitrogen-rich fraction (5, 7, 8) is drawn off from the distillation column system and compressed at least in part in a circulation compressor (9, 1063). A first part (12, 13) of nitrogen-rich fraction (5, 7, 8) is fed downstream from circulation compressor (9) to the liquefaction chamber of a condenser-evaporator (14) and is condensed under a pressure higher than the operating pressure of single column (4), so to form nitrogen-rich liquid (15, 16). A liquid oxygen-enriched fraction (231) from the distillation column system is at least partially evaporated in the evaporation chamber of condenser-evaporator (14). A first oxygen-enriched gas (234, 533) formed in the evaporation chamber of condenser-evaporator (14), is introduced into single column (4).