Abstract: A method of estimating a parameter of physiological significance in the central nervous system (CNS) is provided. The method comprises (a) providing one or more images of the brain or cerebral spinal fluid (CSF) in a subject to whom a dose of a contrast agent (CA) has been administered; (b) determining, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the brain or CSF, thereby generating concentration data; (c) describing the time-based behavior of concentrations of CA within the brain or CSF using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters; and (d) fitting, using computer code, the pharmacokinetic model to the concentration data, varying one or more parameters, wherein the best fit estimates a parameter of physiological significance in the CNS.

Abstract: A method is provided for estimating a parameter of physiological significance. One or more images are provided of a tissue in a subject to whom a dose of a contrast agent (CA) has been administered, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the tissue is determined, thus generating concentration data. The time-based behavior of concentrations of CA within the tissue is determined using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters. Using computer code, the pharmacokinetic model is fit to the concentration data, varying one or more parameters, such that a best fit estimate of a parameter of physiological significance is provided.

Abstract: A method of estimating a parameter of physiological significance in the central nervous system (CNS) is provided. The method comprises (a) providing one or more images of the brain or cerebral spinal fluid (CSF) in a subject to whom a dose of a contrast agent (CA) has been administered; (b) determining, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the brain or CSF, thereby generating concentration data; (c) describing the time-based behavior of concentrations of CA within the brain or CSF using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters; and (d) fitting, using computer code, the pharmacokinetic model to the concentration data, varying one or more parameters, wherein the best fit estimates a parameter of physiological significance in the CNS.

Abstract: A method is provided for estimating a parameter of physiological significance. One or more images are provided of a tissue in a subject to whom a dose of a contrast agent (CA) has been administered, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the tissue is determined, thus generating concentration data. The time-based behavior of concentrations of CA within the tissue is determined using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters. Using computer code, the pharmacokinetic model is fit to the concentration data, varying one or more parameters, such that a best fit estimate of a parameter of physiological significance is provided.

Abstract: The invention relates to a device for carrying out a tomographic method, in particular for carrying out single-photon tomography, with at least one multi-hole collimator and at least one detector, for recording photons which pass through the multi-hole collimator. The above is characterised in comprising means which permit a relative translational movement between an object under investigation and the detector(s) with a positional accuracy of less than 1 millimeter. The relative positional change between object and detector(s) during the execution of the method is taken into account in the subsequent reconstruction method to an accuracy of less than 1 mm, in particular, less than 0.1 mm. A reconstruction method is used for the above which takes into account the positional and angular information between object and detector. Said method may be controlled by and carried out on a current PC.

Abstract: The reconstruction of artifact free images is made possible by the implementation of a SPECT imaging device that employs helical scanning. The SPECT imaging device includes a detector configured to detect photons, such as photons, that are projected onto it. A collimator is axially aligned with the detector and includes a plurality of pinholes configured to create overlapping projections of the photons. An object support structure is configured to move in a direction that is axially aligned with the detector and collimator. The detector and collimator are configured to rotate around the object support structure in a transaxial plane to the object support structure while the object support structure moves in an axial direct to the collimator and detector.

Abstract: The invention relates to a device for carrying out a tomographic method, in particular for carrying out single-photon tomography, with at least one multi-hole collimator and at least one detector, for recording photons which pass through the multi-hole collimator. The above is characterised in comprising means which permit a relative translational movement between an object under investigation and the detector(s) with a positional accuracy of less than 1 millimetre. The relative positional change between object and detector(s) during the execution of the method is taken into account in the subsequent reconstruction method to an accuracy of less than 1 mm, in particular, less than 0.1 mm. A reconstruction method is used for the above which takes into account the positional and angular information between object and detector. Said method may be controlled by and carried out on a current PC.