Abstract: The present disclosure concerns a compaction apparatus having a hopper housing defining a hopper chamber to receive materials; a container storing the materials in a compacted fashion; a screw conveying the materials from the hopper chamber to the container and comprising a screw hopper segment extending in the hopper chamber; a partition assembly located between the hopper and the container; and a containment assembly comprising a flap mounted to the hopper housing and being movable between a loading configuration wherein the flap uncovers the screw hopper segment, and a containment configuration in which the flap at least partially covers the screw hopper segment to contain the materials in the hopper chamber.

Abstract: The present disclosure concerns a compaction apparatus having a hopper housing defining a hopper chamber to receive materials; a container storing the materials in a compacted fashion; a screw conveying the materials from the hopper chamber to the container and comprising a screw hopper segment extending in the hopper chamber; a partition assembly located between the hopper and the container; and a containment assembly comprising a flap mounted to the hopper housing and being movable between a loading configuration wherein the flap uncovers the screw hopper segment, and a containment configuration in which the flap at least partially covers the screw hopper segment to contain the materials in the hopper chamber.

Abstract: Compounds and methods for designing and identifying compounds which inhibit TFPP-like aspartyl protease enzymes by targeting the aspartic acid residues of the active site or mimicking peptides corresponding to the region surrounding the substrate's cleavage site are provided. Agents identified as inhibitors of TFPP-like aspartyl proteases such as type 4 prepilin peptidases are expected to be useful as anti-bacterial agents and in inhibiting development of drug resistant strains of bacteria.