Abstract: A tracking reference fixation support configured to fasten a medical tracking reference to a patient's head, the fixation support comprising an elastically deformable base-plate having a bottom surface, the base-plate being configured to rest via the bottom surface against the surface of a patient's head; an interface-plate providing an interface for rigidly attaching a medical tracking reference to the fixation support; and at least one joint that couples the interface-plate to the base-plate, which allows the base-plate to deform while the interface-plate remains substantially dimensionally stable. The invention further relates to a corresponding tracking reference headband and to a corresponding method of providing a patient's head with a tracking reference.

Abstract: Compounds of formula (I), process for their production and their use as pharmaceuticals.

Abstract: Compounds of formula (I), process for their production and their use as pharmaceuticals.

Abstract: Compounds of formula (I), process for their production and their use as pharmaceuticals.

Abstract: Compounds of formula (I), process for their production and their use as pharmaceuticals.

Abstract: The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, m, n, o and p are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention covers aminoquinolone compounds of general formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8, X and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to compounds of formula (I) processes for their production and their use as pharmaceuticals. The compounds are inhibitors of Casein kinase 1 alpha and/or delta (CSNK1? and/or ?) useful for the treatment of proliferative disorders.

Abstract: The present invention covers heterocyclic compounds of general formula (I) in which T, U, Y, Z, R1 and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer disorders, as a sole agent or in combination with other active ingredients.

Abstract: The invention relates to an instrument for use in computer guided surgery. The instrument includes a shaft and a reference element adapter, wherein the reference element adapter is directly couplable to the shaft and rotatable about the shaft. A selectively operable mechanical retainer provides retention of the reference element adapter to an instrument shaft adapting interface of the instrument shaft. The instrument also includes a reference element orientating mechanism arranged at an interface between the instrument shaft adapting interface and the reference element adaptor. The reference element orienting mechanism is capable of fixing at least one angular position of the reference element. The instrument also includes a grip piece interface on the instrument shaft, and a grip piece is selectively couplable to the grip piece interface.

Abstract: The invention relates to a method for visually assisting the alignment of a medical instrument, wherein the instrument is visually displayed on an image output in a positional relationship to a part of a patient's body by means of a medical navigation system, wherein an orientation aid is displayed as a virtual model shape at the instrument or in a particular positioning with respect to a characteristic part of the instrument. It also relates to a planning method for optimized instrument alignment with the aid of such an image assisting method.

Abstract: Provided is a method for controlling a surgical navigation system. A detection unit for detecting system control inputs made by a user is associated with a surgical navigation system, the navigation system is controlled in accordance with the control inputs, and user gestures are used as said control inputs. A gesture or a initiating user gesture defines a virtual volume surrounding the initiating gesture's limits, and further predetermined gestures made in the virtual volume are recognized as a control input. Also provided is a control system for a surgical navigation system. The navigation system is associated with a detection unit for detecting system control inputs made by a user, the navigation system is controlled in accordance with the control inputs, and the detection unit includes a gesture detection system for detecting user gestures.

Abstract: A tracking reference fixation support configured to fasten a medical tracking reference to a patient's head, the fixation support comprising an elastically deformable base-plate having a bottom surface, the base-plate being configured to rest via the bottom surface against the surface of a patient's head; an interface-plate providing an interface for rigidly attaching a medical tracking reference to the fixation support; and at least one joint that couples the interface-plate to the base-plate, which allows the base-plate to deform while the interface-plate remains substantially dimensionally stable. The invention further relates to a corresponding tracking reference headband and to a corresponding method of providing a patient's head with a tracking reference.

Abstract: Provided is a method for controlling a surgical navigation system. A detection unit for detecting system control inputs made by a user is associated with a surgical navigation system, the navigation system is controlled in accordance with the control inputs, and user gestures are used as said control inputs. A gesture or a initiating user gesture defines a virtual volume surrounding the initiating gesture's limits, and further predetermined gestures made in the virtual volume are recognized as a control input. Also provided is a control system for a surgical navigation system. The navigation system is associated with a detection unit for detecting system control inputs made by a user, the navigation system is controlled in accordance with the control inputs, and the detection unit includes a gesture detection system for detecting user gestures.

Abstract: The invention relates to a control system for a surgical navigation system, wherein the navigation system is associated with a detection unit for detecting system control inputs made by a user, and wherein the navigation system is controlled in accordance with the control inputs and the detection unit comprises a gesture detection for detecting user gestures. The invention also relates to a method for controlling a surgical navigation system, wherein a detection unit for detecting system control inputs made by a user is associated with the surgical navigation system, the navigation system is controlled in accordance with the control inputs, and user gestures are used as said control inputs.

Abstract: The invention relates to an instrument for use in computer guided surgery. The instrument includes a shaft and a reference element adapter, wherein the reference element adapter is directly couplable to the shaft and rotatable about the shaft. A selectively operable mechanical retainer provides retention of the reference element adapter to an instrument shaft adapting interface of the instrument shaft. The instrument also includes a reference element orientating mechanism arranged at an interface between the instrument shaft adapting interface and the reference element adaptor. The reference element orienting mechanism is capable of fixing at least one angular position of the reference element. The instrument also includes a grip piece interface on the instrument shaft, and a grip piece is selectively couplable to the grip piece interface.

Abstract: A calibration device for calibrating a medical instrument, comprising at least one supporting surface which is configured to provide support for a medical instrument which is brought into contact with at least one of the one or more supporting surfaces for a calibration procedure, wherein the calibration device comprises means which exert at least one force on the medical instrument, the at least one force being directed towards the at least one of the one or more supporting surfaces.

Abstract: The invention relates to an instrument for use in computer guided surgery. The instrument includes a shaft and a reference element adapter, wherein the reference element adapter is directly couplable to the shaft and rotatable about the shaft. A selectively operable mechanical retainer provides retention of the reference element adapter to an instrument shaft adapting interface of the instrument shaft. The instrument also includes a reference element orientating mechanism arranged at an interface between the instrument shaft adapting interface and the reference element adaptor. The reference element orienting mechanism is capable of fixing at least one angular position of the reference element. The instrument also includes a grip piece interface on the instrument shaft, and a grip piece is selectively couplable to the grip piece interface.