Patents by Inventor Christian LeGuern

Christian LeGuern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immune Regulation
    Publication number: 20140134131
    Abstract: A method of regulating the immune system of a subject that involves removing antigen presenting cells from subject and loading preselected class II peptide fragments onto the subjects APC's outside the body of the subject.
    Type: Application
    Filed: January 15, 2014
    Publication date: May 15, 2014
    Applicant: The General Hospital Corporation
    Inventor: Christian A. LeGuern
  • Immune regulation
    Patent number: 8652462
    Abstract: A method of regulating the immune system of a subject that involves removing antigen presenting cells from subject and loading preselected class II peptide fragments onto the subjects APC's outside the body of the subject.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: February 18, 2014
    Assignee: The General Hospital Corporation
    Inventor: Christian A. Leguern
  • Immune regulation
    Publication number: 20080124348
    Abstract: A method of regulating the immune system of a subject that involves removing antigen presenting cells from subject and loading preselected class II peptide fragments onto the subjects APC's outside the body of the subject.
    Type: Application
    Filed: April 6, 2007
    Publication date: May 29, 2008
    Inventor: Christian A. Leguern
  • Immune regulation
    Publication number: 20050191280
    Abstract: A method of regulating the immune system of a subject that involves removing antigen presenting cells from subject and loading preselected class II peptide fragments onto the subjects APC's outside the body of the subject.
    Type: Application
    Filed: February 28, 2003
    Publication date: September 1, 2005
    Inventor: Christian Leguern
  • Transgenic swine & swine cells having human HLA genes
    Patent number: 6558663
    Abstract: Methods of promoting tolerance and inhibiting NK cell mediated attack in a human recipient to a swine graft are disclosed The methods include introducing into the recipient a swine hematopoietic stem cell which has been transformed with a transgene encoding a human MHC class I protein that inhibits recipient NK cell mediated attack.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: May 6, 2003
    Assignee: The General Hospital Corporation
    Inventors: Joerg Seebach, David H. Sachs, Harout DerSimonian, Christian LeGuern
  • Transgenic swine and swine cells having human HLA genes
    Patent number: 6030833
    Abstract: A genetically engineered swine cell having a transgene encoding a human HLA protein.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: February 29, 2000
    Assignee: The General Hospital
    Inventors: Joerg Seebach, David H. Sachs, Harout DerSimonian, Christian LeGuern
  • DNA encoding procine interleukin-10
    Patent number: 5624823
    Abstract: Purified DNA encoding porcine IL-10, porcine IL-10, and methods of inducing immunological tolerance and inhibiting graft versus host disease.
    Type: Grant
    Filed: August 30, 1993
    Date of Patent: April 29, 1997
    Assignee: The General Hospital Corporation
    Inventors: David H. Sachs, Christian A. Leguern, Megan Sykes, Gilles JF. Blancho