Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

Abstract: A device for breaking the electrical connection to a battery cell (1) in the event of outgassing has the cell pole (3) on the outgassing valve side connected to an electrical contact point (5) at a connection point (4) via a connecting lead (2) which forms a fuse. The device, requiring few components and having a compact design, enables a reliable electrical and thermal protection of neighboring cells of an outgassing battery cell against overloading and prevents the spread of a thermal runaway. The device provides a spacer (6) between the connection point (4) and the contact point (5) that electrically isolates the connection point (4) from the contact point (5) in the event of outgassing and that retains the cell pole (3).

Abstract: A fuel injector has a piezoelectric or magnetostrictive actuator, which actuates a valve-closure member cooperating with a valve-seat surface a sealing seat. An hydraulic coupler includes a master piston, a slave piston, and a coupler volume formed in-between, the coupler volume being connected to a compensating chamber via a throttle. An elastic flexible section delimits the compensating chamber at least partially, and the coupler volume, the throttle, and the compensating chamber are filled with an hydraulic medium. The flexible section exerts a pressure on the hydraulic medium due to prestressing, and the force of a compression spring, which is braced either directly and/or via fixed components on the slave piston and the master piston, is directed with an initial stress in such a way that the force enlarges the coupler volume.

Abstract: A fuel injector has a piezoelectric or magnetostrictive actuator, which actuates a valve-closure member cooperating with a valve-seat surface a sealing seat. An hydraulic coupler includes a master piston, a slave piston, and a coupler volume formed in-between, the coupler volume being connected to a compensating chamber via a throttle. An elastic flexible section delimits the compensating chamber at least partially, and the coupler volume, the throttle, and the compensating chamber are filled with an hydraulic medium. The flexible section exerts a pressure on the hydraulic medium due to prestressing, and the force of a compression spring, which is braced either directly and/or via fixed components on the slave piston and the master piston, is directed with an initial stress in such a way that the force enlarges the coupler volume.