Patents by Inventor Christian Leumann

Christian Leumann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic nucleosides and oligomers prepared therefrom
    Patent number: 11919922
    Abstract: Oligomers can be prepared from bicyclic nucleoside. The nucleosides can be a compound of formula (I) in which each of T1 and T2 is independently OR1 or OR2; R1 is H or a hydroxyl protecting group, R2 is a phosphorus moiety; and Bx is a nucleobase. The compounds, bicyclic nucleosides and the oligomers are useful for the prevention, treatment or diagnosis of muscular dystrophy.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: March 5, 2024
    Assignee: Universitat Bern
    Inventors: Christian Leumann, Damien Evéquoz
  • NOVEL BICYCLIC NUCLEOSIDES AND OLIGOMERS PREPARED THEREFROM
    Publication number: 20220089632
    Abstract: Oligomers can be prepared from bicyclic nucleoside. The nucleosides can be a compound of formula (I) in which each of T1 and T2 is independently OR1 or OR2; R1 is H or a hydroxyl protecting group, R2 is a phosphorus moiety; and Bx is a nucleobase. The compounds, bicyclic nucleosides and oligomers are useful for the prevention, treatment or diagnosis of muscular dystrophy.
    Type: Application
    Filed: April 26, 2021
    Publication date: March 24, 2022
    Inventors: Christian Leumann, Damien Evéquoz
  • Bicyclic nucleosides and oligomers prepared therefrom
    Patent number: 11028117
    Abstract: Oligomers can be prepared from bicyclic nucleosides. The nucleosides can be a compound of formula (I) in which each of T1 and T2 is independently OR1 or OR2; R1 is H or a hydroxyl protecting group, R2 is a phosphorus moiety; and Bx is a nucleobase. The compounds, bicyclic nucleosides and oligomers are useful for the prevention, treatment or diagnosis of muscular dystrophy.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: June 8, 2021
    Assignee: UNIVERSITÄT BERN
    Inventors: Christian Leumann, Damien Evéquoz
  • NOVEL BICYCLIC NUCLEOSIDES AND OLIGOMERS PREPARED THEREFROM
    Publication number: 20190345188
    Abstract: Oligomers can be prepared from bicyclic nucleosides. The nucleosides can be a compound of formula (I) in which each of T1 and T2 is independently OR1 or OR2; wherein R1 is H or a hydroxyl protecting group, R2 is a phosphorus moiety; and Bx is a nucleobase. The compounds, bicyclic nucleosides and oligomers are useful for the prevention, treatment or diagnosis of muscular dystrophy.
    Type: Application
    Filed: November 29, 2017
    Publication date: November 14, 2019
    Inventors: Christian Leumann, Damien Evéquoz
  • Tricyclo-DNA antisense oligonucleotides, compositions, and methods for the treatment of disease
    Patent number: 10465191
    Abstract: Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stein-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: November 5, 2019
    Assignees: ASSOCIATION INSTITUT DE MYOLOGIE, SORBONNE UNIVERSITE, UNIVERSITAT BERN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Daniel Schumperli, Christian Leumann, Denis Furling, Luis Garcia, Thomas Voit
  • TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
    Publication number: 20180162897
    Abstract: The present invention provides fluorine substituted tricyclic nucleosides of formula (I) wherein: the substituents are as defined in the claims. The present invention further provides oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound enhances one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions.
    Type: Application
    Filed: November 22, 2017
    Publication date: June 14, 2018
    Inventor: Christian LEUMANN
  • Tricyclic nucleosides and oligomeric compounds prepared therefrom
    Patent number: 9862742
    Abstract: The present invention provides fluorine substituted tricyclic nucleosides of formula (I) wherein: the substituents are as defined in the claims. The present invention further provides oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound enhances one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: January 9, 2018
    Assignee: UNIVERSITÄT BERN
    Inventor: Christian Leumann
  • TRICYCLO-DNA ANTISENSE OLIGONUCLEOTIDES, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
    Publication number: 20170260524
    Abstract: Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stein-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA.
    Type: Application
    Filed: February 9, 2017
    Publication date: September 14, 2017
    Inventors: Daniel SCHUMPERLI, Christian LEUMANN, Denis FURLING, Luis GARCIA, Thomas VOIT
  • Tricyclo-phosphorothioate DNA
    Patent number: 9738891
    Abstract: The present invention relates to a nucleic acid molecule containing a sequence of tricyclo nucleosides joined by internucleoside phosphorothioate linkage. The invention also relates to synthetic antisense oligonucleotides and to methods employing the same.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: August 22, 2017
    Assignees: ASSOCIATION INSTITUT DE MYOLOGIE, UNIVERSITAT BER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Christian Leumann, Luis Garcia, Thomas Voit
  • TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
    Publication number: 20160122372
    Abstract: The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions. In certain embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
    Type: Application
    Filed: January 5, 2016
    Publication date: May 5, 2016
    Inventors: Christian Leumann, Branislav Dugovic, Jory Lietard
  • Tricyclic nucleosides and oligomeric compounds prepared therefrom
    Patent number: 9249178
    Abstract: The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions. In certain embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 2, 2016
    Inventors: Christian Leumann, Branislav Dugovic, Jory Liétard
  • TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
    Publication number: 20160002280
    Abstract: The present invention provides fluorine substituted tricyclic nucleosides of formula (I) wherein: the substituents are as defined in the claims. The present invention further provides oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound enhances one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 7, 2016
    Inventor: Christian Leumann
  • TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
    Publication number: 20150141637
    Abstract: The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions. In certain embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
    Type: Application
    Filed: March 15, 2013
    Publication date: May 21, 2015
    Applicant: UNIVERSITÄT BERN
    Inventors: Christian Leumann, Branislav Dugovic, Jory Liétard
  • TRICYCLO-PHOSPHOROTHIOATE DNA
    Publication number: 20140296323
    Abstract: The present invention relates to a nucleic acid molecule containing a sequence of tricyclo nucleosides joined by internucleoside phosphorothioate linkage. The invention also relates to synthetic antisense oligonucleotides and to methods employing the same.
    Type: Application
    Filed: October 12, 2012
    Publication date: October 2, 2014
    Inventors: Christian Leumann, Luis Garcia, Thomas Voit
  • TRICYCLO-DNA ANTISENSE OLIGONUCLEOTIDES, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
    Publication number: 20120149756
    Abstract: Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stem-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA.
    Type: Application
    Filed: April 9, 2010
    Publication date: June 14, 2012
    Applicants: Associatin Institut de Myologie, Centre National De La Recherche Scientifique, Universitât Bern, Universite Pierre et Marie Curie
    Inventors: Daniel Schümperli, Christian Leumann, Denis Furling, Luis Garcia, Thomas Voit
  • Bicyclic nucleosides, oligonucleotides, process for their preparation and intermediates
    Patent number: 5393878
    Abstract: Compounds of the formula I in the form of the racemates or enantiomers thereof, ##STR1## in which R.sub.1 and R.sub.2 independently of one another are hydrogen or a protective group, and B is a purine or pyrimidine radical or an analogue thereof, can be used as antiviral active ingredients or for the preparation of biologically active oligonucleotides.
    Type: Grant
    Filed: March 17, 1994
    Date of Patent: February 28, 1995
    Assignee: Ciba-Geigy Corporation
    Inventor: Christian Leumann
  • Bicyclic nucleosides, oligonucleotides, process for their preparation and intermediates
    Patent number: 5319080
    Abstract: Compounds of the formula I in the form of the racemates or enantiomers thereof, ##STR1## in which R.sub.1 and R.sub.2 independently of one another are hydrogen or a protective group, and B is a purine or pyrimidine radical or an analogue thereof, can be used as antiviral active ingredients or for the preparation of biologically active oligonucleotides.
    Type: Grant
    Filed: October 13, 1992
    Date of Patent: June 7, 1994
    Assignee: Ciba-Geigy Corporation
    Inventor: Christian Leumann