Abstract: The present invention provides methods for utilizing blended compositions of acetonitrile and toluene as organic wash solvents in the production of a synthetic oligonucleotide, the blended compositions producing higher synthetic oligonucleotide yields than a pure acetonitrile wash solvent. The method also provides a process for removing one or more impurities from the acetonitrile and toluene containing wash solvent received as a waste stream from the oligonucleotide synthesis process. The process includes adding at least one of an iodine reactive compound, a sulfur reactive compound and/or an acidic reactive compound to the waste stream, and fractionating the waste stream. The fractionation produces an overhead fraction and a bottom fraction where the overhead fraction includes the acetonitrile and the toluene, and the bottom fraction includes the one or more impurities.

Abstract: A method for commissioning a door system with the door system having door components, with at least one door component being designed as a control unit, with the method including the following steps: storing an electronic configuration of the door system in the control unit and/or a mobile terminal, and carrying out at least one commissioning step by the electronic configuration.

Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.

Abstract: A method and device are provided for marking electrical devices which can be arranged in a row on a support rail, with the aid of a laser head, wherein the support rail is pivotable about its longitudinal axis and the laser head is guided such that it can be moved at least along the longitudinal axis of the support rail. A number of marking instructions, each including a marking content and a position and an orientation of the surface to which the marking content is to be applied are specified. An image of at least a section of the support rail and of at least one electrical device are created from an image capture device and at least one of the positions at which one of the marking contents is to be applied is corrected based on an evaluation of the image. The marking instructions are grouped into marking levels in such a way that all marking instructions of one marking level can be applied by the laser head without a movement of the laser head or the support rail.

Abstract: There is provided a method for generating traffic data indicative of a traffic volume and/or traffic density within a navigable network in an area covered by an electronic map, the electronic map comprising a plurality of segments representing navigable elements of the navigable network. The method generally comprises obtaining positional data relating to the movement of a plurality of devices along the navigable elements represented by the segments of the electronic map; determining, using (at least) positional data relating to one or more congested segments within a region of the navigable network, an estimate of one or more average penetration rates for the region; determining a sample volume for a non-congested segment within the region based on the obtained positional data; and estimating, using the determined sample volume and a selected one of the average penetration rates for the region, a traffic volume and/or traffic density for the non-congested segment.

Abstract: The present invention generally relates to antibodies that bind to GPRC5D, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: A wing for an aircraft is disclosed having a fixed wing, a foldable wing tip portion and a flight latch device for latching the foldable wing tip portion in the extended position, wherein the flight latch device includes a housing, a latch bolt, and a motor for driving the latch bolt between the latched and unlatched positions. A flight latch device includes a threaded shaft rotationally driven by the motor, a nut engaging the shaft, so that the nut can rotate relative to the shaft, the nut is connected to the housing via a linear guide and is connected to the latch bolt for common linear movement with the latch bolt, and the flight latch device includes an offset compensation, providing that the shaft is supported pivotable relative to the housing and the latch bolt is coupled to the nut via a compensational bearing allowing angular play between the nut and the latch bolt.

Abstract: A wing for an aircraft is disclosed having a fixed wing, a foldable wing tip portion mounted to the fixed wing via a hinge rotatable about a hinge axis between an extended position and a folded position, and an actuation unit for actuating the foldable wing tip portion for movement about the hinge axis. The wing includes a brake unit for securing the foldable wing tip portion in the folded position, and the brake unit is formed separately from the actuation unit.

Abstract: An actuation unit for actuating a foldable wing tip portion of a wing for an aircraft is disclosed including a motor configured to be mounted to a fixed wing for an aircraft, a drive pinion driven rotationally by the motor, a first rack configured to be mounted to the fixed wing, a second rack configured to be mounted to the foldable wing tip portion, a third rack configured to be mounted to the fixed wing movably along a defined first movement path and drivingly engaged by the drive pinion, and a transfer pinion mounted to the third rack rotatably about an axis of rotation extending perpendicular to the first movement path.

Abstract: A wing for an aircraft is disclosed having a fixed wing, a foldable wing tip portion, and a flight latch device for latching the foldable wing tip portion in the extended position, wherein the flight latch device includes a housing, a latch bolt linearly movable relative to the housing, and a motor for driving the latch bolt. The flight latch device includes a threaded shaft having an external thread and being mounted to the housing in a torque proof manner, the flight latch device includes a nut having an internal thread engaging the external thread of the shaft, so that the nut can rotate about the shaft along the external thread.

Abstract: An internal combustion engine for a motor vehicle includes a crankshaft, a camshaft, a cylinder, a piston movably disposed in the cylinder and coupled to the crankshaft for driving the crankshaft, a first gas exchange valve which is assigned to the cylinder, a first valve clearance compensation device, where via the first valve clearance compensation device the first gas exchange valve is displaceable between a first open position and a first closed position by a first cam of the camshaft, and a control unit. The control unit is configured to align the camshaft such that the first valve clearance compensation device is pressure-loaded in the idle state of the crankshaft by a plateau area assigned to the first cam to hold the first gas exchange valve in the first open position.

Abstract: A method of determining whether one or more navigable elements of a navigable network within a geographic area are still affected by a precipitation weather event. A quantity parameter is associated with each segment of an electronic map representing the navigable network and indicates the amount of precipitation remaining on the navigable element or portion thereof represented by the segment. The value of the quantity parameter increases in the presence of any precipitation weather event, and decreases ac cording to a predefined function with respect to time in the absence of any such precipitation weather event. A speed of travel of one or more devices along the navigable element or portion thereof represented by a segment is determined and compared to an expected speed of travel for the segment; the value of the quantity parameter being decreased based on the comparison.

Abstract: A wing for an aircraft, comprising a fixed wing, a foldable wing tip portion mounted to the fixed wing via a first hinge rotatably about a first hinge axis between an extended and folded positions, and an actuation unit to actuate the foldable wing tip portion for movement about the first hinge axis. The actuation unit comprises a link, a first and a second linear actuator. The link is rotatably mounted to the fixed wing via a second hinge, the first linear actuator is rotatably mounted to the fixed wing via a third hinge spaced from the second hinge, and is rotatably mounted to the link via a fourth hinge spaced from the second hinge. The second linear actuator is rotatably mounted to the foldable wing tip portion via a fifth hinge, and is rotatably mounted to the link via a sixth hinge spaced from the second hinge.

Abstract: An actuation unit (15) for actuating a foldable wing tip portion (9) of a wing (3) for an aircraft (1). The actuation unit (15) includes a track (25) configured to be mounted to a fixed wing (5), a carriage (27) configured to engage the track (25) for guided movement along the track (25), and configured to be coupled to a drive unit (31) for driving the carriage (27) along the track (25), and a link (29) configured to be coupled to the carriage (27) and configured to be coupled to a foldable wing tip portion (9).

Abstract: A wing (3) for an aircraft (1) including a fixed wing (5), a foldable wing tip portion (9) mounted to the fixed wing (5) via a first hinge (11) rotatable about a first hinge axis (13) between an extended position (15) and a folded position (17), and an actuation unit (19) arranged at the fixed wing (5) and coupled to the foldable wing tip portion (9) via a linkage (21) including a first link element (23) and a second link element (25), wherein the first link element (23) is mounted to a rotatable output (27) of the actuation unit (19) and is rotatably coupled to the second link element (25) via a second hinge (29), and wherein the second link element (25) is rotatably coupled to the foldable wing tip portion (9) via a third hinge (31).

Abstract: A latching device for a wing (3) including a base (11) and a tip section (13). There is a first bore (27) extending from the base section (11) and a second bore (27) extending from the tip section (13) wherein the bores are aligned when the tip section is deployed for flight and out of alignment when the tip section (13) is folded. The latching device (29) includes a housing (33) with an interior cavity (35), a spindle (39) in the interior cavity, a nut (47) threaded on the spindle, wherein rotation of the spindle causes; a latching bolt (31) coupled to the nut (47) and being moved as the nut moves along the rotating spindle between retracted and extended positions; a guide (49) to guide the nut (47) along the spindle and of the latching bolt between the retracted position and the extended position, and a latch actuator (41).

Abstract: A wing for an aircraft is disclosed having a fixed wing and a foldable wing tip portion mounted to the fixed wing via a hinge rotatable about a hinge axis between an extended position and a folded position. The wing may include an actuation unit with reduced complexity, and may include a ground latch device for latching the foldable wing tip portion in the folded position.

Abstract: An actuation unit (15) for actuating a foldable wing tip portion (9) includes a first housing part (19) including a first attachment device (23) configured for attachment to a fixed wing (5), and a second housing part (21) including a second attachment device (25) configured for attachment to a foldable wing tip portion (9). The second housing part (21) is rotatable about a main axis of rotation (35). The second housing part (21) includes a toothed rack (37) having a concave shape and facing the main axis of rotation (35). A drive pinion (39) is supported at the first housing part (19) and engaging the toothed rack (37) for driving the second housing part (21) rotatingly relative to the first housing part (19). The drive pinion (39) is driven by a coupling arrangement (43) that is configured to be coupled to an output (45) of a motor unit (47).

Abstract: A wing for an aircraft is disclosed having a fixed wing, a foldable wing tip portion, and a flight latch device for latching the foldable wing tip portion in the extended position, wherein the flight latch device includes a housing, a latch bolt linearly movable relative to the housing, and a motor for driving the latch bolt. The flight latch device includes a threaded shaft having an external thread and being mounted to the housing in a torque proof manner, the flight latch device includes a nut having an internal thread engaging the external thread of the shaft, so that the nut can rotate about the shaft along the external thread, the motor is arranged coaxially around the nut, wherein a rotor part is mounted to the nut in a torque proof manner, and wherein a stator part is rotatably connected to the rotor part and is connected to the housing by a first linear guide allowing linear movement and inhibiting rotation of the stator part.

Abstract: An actuation unit for actuating a foldable wing tip portion of a wing for an aircraft is disclosed including a motor configured to be mounted to a fixed wing for an aircraft, a drive pinion driven rotationally by the motor, a first rack configured to be mounted to the fixed wing, a second rack configured to be mounted to the foldable wing tip portion, a third rack configured to be mounted to the fixed wing movably along a defined first movement path and drivingly engaged by the drive pinion, and a transfer pinion mounted to the third rack rotatably about an axis of rotation extending perpendicular to the first movement path, wherein the first rack engages the transfer pinion at a first side and the second rack engages the transfer pinion at an opposite second side of the transfer pinion, such that, when the drive pinion drives the third rack along the first movement path, the transfer pinion drives the second rack along a second movement path.