Patents by Inventor Christian LOTHSCHUETZ
Christian LOTHSCHUETZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11407730Abstract: The present invention relates to a method of preparing racemic nicotine comprising: (i) reacting ethyl nicotinate and N-vinylpyrrolidone in the presence of an alcoholate base to 3-nicotinoyl-1-vinylpyrrolidin-2-one; (ii) reacting the 3-nicotinoyl-1-vinylpyrrolidin-2-one with an acid to myosmine; (iii) reducing the myosmine to nornicotine using a reducing agent; and (iv) methylating the nornicotine to obtain the racemic nicotine.Type: GrantFiled: December 18, 2018Date of Patent: August 9, 2022Assignees: Siegfried AG, Contraf-Nicotex-Tobacco GmbHInventors: Beat Theodor Weber, Christian Lothschütz, Ben Pan
-
Patent number: 11091458Abstract: The present invention relates to a method of preparing racemic nicotine comprising: (i) reacting ethyl nicotinate and N-vinylpyrrolidone in the presence of an alcoholate base to 3-nicotinoyl-1-vinylpyrrolidin-2-one; (ii) reacting the 3-nicotinoyl-1-vinylpyrrolidin-2-one with an acid to myosmine; (iii) reducing the myosmine to nornicotine using a reducing agent; and (iv) methylating the nornicotine to obtain the racemic nicotine.Type: GrantFiled: December 18, 2018Date of Patent: August 17, 2021Assignees: Siegfried AG, Contraf-Nicotex-Tobacco GmbHInventors: Beat Theodor Weber, Christian Lothschütz, Ben Pan
-
Patent number: 10822304Abstract: The current invention offers a process for the production of N-Boc-2-amino-3,3-dimethylbutyric acid by a reaction of tert-Leucine with di-tert-butyl-dicarbonate, the process comprising (i) contacting the tert-Leucine with di-tert-butyl-dicarbonate in an aqueous medium, optionally comprising a first organic solvent, in the presence of an inorganic base, (ii) optionally removing the first organic solvent, (iii) optionally extracting the resulting N-Boc-2-amino-3,3-dimethylbutyric acid into a second organic solvent, (iv) isolating the product by precipitation from the reaction mixture at acidic pH, and (v) optionally reuse the first and/or second organic solvents recovered from step (ii) and/or step (iv) for the next production cycle. The process is sufficiently short, uses preferably environmental friendly solvents, avoids waste and leads to good yields.Type: GrantFiled: November 23, 2017Date of Patent: November 3, 2020Assignee: Siegfried (Nantong) Pharmaceuticals Co. Ltd.Inventors: Jiang Chen, Christian Lothschuetz, Beat Theodor Weber
-
Publication number: 20200331884Abstract: The present invention relates to a method of preparing racemic nicotine comprising: (i) reacting ethyl nicotinate and N-vinylpyrrolidone in the presence of an alcoholate base to 3-nicotinoyl-1-vinylpyrrolidin-2-one; (ii) reacting the 3-nicotinoyl-1-vinylpyrrolidin-2-one with an acid to myosmine; (iii) reducing the myosmine to nornicotine using a reducing agent; and (iv) methylating the nornicotine to obtain the racemic nicotine.Type: ApplicationFiled: December 18, 2018Publication date: October 22, 2020Applicants: SIEGFRIED AG, CONTRAF-NICOTEX-TOBACCO GMBHInventors: Beat Theodor Weber, Christian Lothschütz, Ben Pan
-
Publication number: 20190276391Abstract: The current invention offers a process for the production of N-Boc-2-amino-3,3-dimethylbutyric acid by a reaction of tert-Leucine with di-tert-butyl-dicarbonate, the process comprising (i) contacting the tert-Leucine with di-tert-butyl-dicarbonate in an aqueous medium, optionally comprising a first organic solvent, in the presence of an inorganic base, (ii) optionally removing the first organic solvent, (iii) optionally extracting the resulting N-Boc-2-amino-3,3-dimethylbutyric acid into a second organic solvent, (iv) isolating the product by precipitation from the reaction mixture at acidic pH, and (v) optionally reuse the first and/or second organic solvents recovered from step (ii) and/or step (iv) for the next production cycle. The process is sufficiently short, uses preferably environmental friendly solvents, avoids waste and leads to good yields.Type: ApplicationFiled: November 23, 2017Publication date: September 12, 2019Applicant: Siegfried (Nantong) Pharmaceuticals Co. Ltd.Inventors: Jiang Chen, Christian Lothschuetz, Beat Theodor Weber
-
Patent number: 9815803Abstract: The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) wherein R1 is C1-C8alkyl, C1-C8haloalkyl, C3-C6 cycloalkyl, aryl or aryl substituted by one to five R11, or aryl-C1-C4alkylene or aryl-C1-C4alkylene substituted by one to five R11; and each R11 is independently C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, cyano or halogen; The invention also relates to intermediates produced by the processes. Compounds of formula (I) are useful intermediates for the production of compounds in the agricultural and pharmaceutical fields.Type: GrantFiled: April 3, 2017Date of Patent: November 14, 2017Assignee: Syngenta Participations AGInventors: Tomas Smejkal, Helmars Smits, Christian Lothschuetz, Miroslav Terinek
-
Publication number: 20170204072Abstract: The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) wherein R1 is C1-C8alkyl, C1-C8haloalkyl, C3-C6 cycloalkyl, aryl or aryl substituted by one to five R11, or aryl-C1-C4alkylene or aryl-C1-C4alkylene substituted by one to five R11; and each R11 is independently C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, cyano or halogen; The invention also relates to intermediates produced by the processes. Compounds of formula (I) are useful intermediates for the production of compounds in the agricultural and pharmaceutical fields.Type: ApplicationFiled: April 3, 2017Publication date: July 20, 2017Applicant: Syngenta Participations AGInventors: Tomas SMEJKAL, Helmars SMITS, Christian LOTHSCHUETZ, Miroslav TERINEK
-
Patent number: 9643938Abstract: The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) wherein R1 is C1-C8alkyl, C1-C8haloalkyl, C3-C6cycloalkyl, aryl or aryl substituted by one to five R11, or aryl-C1-C4alkylene or aryl-C1-C4alkylene substituted by one to five R11; and each R11 is independently C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, cyano or halogen; The invention also relates to intermediates produced by the processes. Compounds of formula (I) are useful intermediates for the production of compounds in the agricultural and pharmaceutical fields.Type: GrantFiled: April 30, 2015Date of Patent: May 9, 2017Assignee: Syngenta Participations AGInventors: Tomas Smejkal, Helmars Smits, Christian Lothschuetz, Miroslav Terinek
-
Publication number: 20170044116Abstract: The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) wherein R1 is C1-C8alkyl, C1-C8haloalkyl, C3-C6cycloalkyl, aryl or aryl substituted by one to five R11, or aryl-C1-C4alkylene or aryl-C1-C4alkylene substituted by one to five R11; and each R11 is independently C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, cyano or halogen; The invention also relates to intermediates produced by the processes. Compounds of formula (I) are useful intermediates for the production of compounds in the agricultural and pharmaceutical fields.Type: ApplicationFiled: April 30, 2015Publication date: February 16, 2017Applicant: Syngenta Participations AGInventors: Tomas SMEJKAL, Helmars SMITS, Christian LOTHSCHUETZ, Miroslav TERINEK
-
Patent number: 9462807Abstract: The present invention relates to a composition and its use in a method for safening the phytotoxic effect of difenoconazole on a plant or plant propagation material.Type: GrantFiled: January 27, 2014Date of Patent: October 11, 2016Assignee: Syngenta Participations AGInventors: Jeremy Robert Godwin, Alexander Mark Heming, Christian Lothschuetz, Peter Schneiter, Wolfgang Stutz
-
Patent number: 9303054Abstract: The present invention relates to a process for the preparation of a compound of formula (I), wherein X is —CH2—, —CH2—CH2—, —CH2—CH2—CH2— or —CH2—CH2—CH2—CH2—; Y1 is —CH2—; —CH2—CH2— or —NH—; Y2 is NHR7 or SH; wherein R7 is hydrogen, C1-C4alkyl or phenyl; R-1 and R2, independently from each other, represent aliphatic or aromatic groups; R3 and R4, independently from each other, represent aliphatic or aromatic groups; R5 and R6 are each hydrogen or represent together with the carbon atoms to which they are bonded, a phenyl ring; which process comprises reacting a compound of formula II [RuCI2(R8)n]m (II), wherein n is 1 and m is >1 which represents a polymeric structure if R8 is a molecule containing two alkene or alkyne moieties coordinating in an hapto-2 coordination mode to the metal; or n is 4 and m is 1 if R8 is a nitrogen, oxygen or sulfur containing molecule in which said nitrogen, oxygen or sulfur coordinate to the metal; in the presence of an inert solvent which boiling point is from 1 12° C.Type: GrantFiled: April 1, 2014Date of Patent: April 5, 2016Assignee: Syngenta Participations AGInventors: Christian Lothschuetz, Alexandre Christian Saint-Dizier
-
Publication number: 20160046658Abstract: The present invention relates to a process for the preparation of a compound of formula (I), wherein X is —CH2—, —CH2—CH2—, —CH2—CH2—CH2— or —CH2—CH2—CH2—CH2—; Y1 is —CH2—; —CH2—CH2— or —NH—; Y2 is NHR7, or SH; wherein R7 is hydrogen, C1-C4alkyl or phenyl; R—1 and R2, independently from each other, represent aliphatic or aromatic groups; R3 and R4, independently from each other, represent aliphatic or aromatic groups; R5 and R6 are each hydrogen or represent together with the carbon atoms to which they are bonded, a phenyl ring; which process comprises reacting a compound of formula II [RuCI2(R8)n]m (II), wherein n is 1 and m is >1 which represents a polymeric structure if R8 is a molecule containing two alkene or alkyne moieties coordinating in an hapto-2 coordination mode to the metal; or n is 4 and m is 1 if R8 is a nitrogen, oxygen or sulfur containing molecule in which said nitrogen, oxygen or sulfur coordinate to the metal; in the presence of an inert solvent which boiling point is from 112° C.Type: ApplicationFiled: April 1, 2014Publication date: February 18, 2016Applicant: SYNGENTA PARTICIPATIONS AGInventors: Christian LOTHSCHUETZ, Alexandre Christian SAINT-DIZIER
-
Publication number: 20150366203Abstract: The present invention relates to a composition and its use in a method for safening the phytotoxic effect of difenoconazole on a plant or plant propagation material.Type: ApplicationFiled: January 27, 2014Publication date: December 24, 2015Applicant: Syngenta Participations AGInventors: Jeremy Robert GODWIN, Alexander Mark HEMING, Christian LOTHSCHUETZ, Peter SCHNEITER, Wolfgang STUTZ
-
Publication number: 20120108819Abstract: Described are N-heterocyclic carbene complexes of the formula I, where n is 0 or 1, M is a metal atom containing group, R1 is selected from hydrogen alkyl, cycloalkyl, heterocycloalkyl, aryl and hetaryl, R2 is selected from hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl and hetaryl, wherein R1 and R2 do not both stand for hydrogen. Furthermore, also described are methods for their preparation and their use as catalysts employed in a C—C, C—O, C—N or C—H bond formation reaction.Type: ApplicationFiled: October 28, 2011Publication date: May 3, 2012Applicant: BASF SEInventors: A. Stephen K. Hashmi, Christian Lothschütz