Patents by Inventor Christian M. Gampe

Christian M. Gampe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compounds for identifying glycosyltransferase inhibitors
    Patent number: 10106833
    Abstract: The present invention provides moenomycin-based probe compounds of Formula (I) for use in screening inhibitors of bacterial glycosyltransferases. The present invention also provides bacterial glycosyltransferase screening assays using compounds of Formula (I).
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: October 23, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Daniel Evan Kahne, Suzanne Walker Kahne, Christian M. Gampe, Hirokazu Tsukamoto
  • INHIBITORS OF BACTERIAL GLYCOSYL TRANSFERASES
    Publication number: 20180162862
    Abstract: Described herein are compounds of Formula (I?), Formula (IA), Formulae (I)-(VII), pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The invention also provides pharmaceutical compositions of the compounds for human and veterinary use. Compounds of the present invention are useful for inhibiting bacterial growth and therefore are useful in treating and/or preventing bacterial infections. Methods of using the compounds for treating and/or preventing a bacterial infection in a subject are also described.
    Type: Application
    Filed: May 27, 2016
    Publication date: June 14, 2018
    Applicants: President and Fellows of Harvard College, Evotec International GmbH
    Inventors: Christian M. Gampe, Daniel Evan Kahne, Suzanne Walker Kahne, Yuan Qia Cambridge, Stephen East, Alastair L. Parkes, Michelle South, James Hunter, Mark Whittaker, Martin Arthuis
  • Chemoenzymatic methods for synthesizing moenomycin analogs
    Patent number: 9902985
    Abstract: The present invention provides methods of synthesizing moenomycin analogs of Formula (I). The present invention also provides compositions comprising a compound of Formula (I) and kits for synthesizing compounds of Formula (I).
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: February 27, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Daniel Evan Kahne, Suzanne Walker Kahne, Emma Doud, Christian M. Gampe, Hirokazu Tsukamoto
  • CHEMOENZYMATIC METHODS FOR SYNTHESIZING MOENOMYCIN ANALOGS
    Publication number: 20150119561
    Abstract: The present invention provides methods of synthesizing moenomycin analogs of Formula (I). The present invention also provides compositions comprising a compound of Formula (I) and kits for synthesizing compounds of Formula (I).
    Type: Application
    Filed: April 5, 2013
    Publication date: April 30, 2015
    Inventors: Daniel Evan Kahne, Suzanne Walker Kahne, Emma Doud, Christian M. Gampe, Hirokazu Tsukamoto
  • METHODS AND COMPOUNDS FOR IDENTIFYING GLYCOSYLTRANSFERASE INHIBITORS
    Publication number: 20150079618
    Abstract: The present invention provides moenomycin-based probe compounds of Formula (I) for use in screening inhibitors of bacterial glycosyltransferases. The present invention also provides bacterial glycosyltransferase screening assays using compounds of Formula (I).
    Type: Application
    Filed: March 13, 2013
    Publication date: March 19, 2015
    Applicant: President and Fellows of Harvard College
    Inventors: Daniel Evan Kahne, Suzanne Walker Kahne, Christian M. Gampe, Hirokazu Tsukamoto