Abstract: In some aspects, the disclosure relates to compositions and methods useful for inhibiting SOD1 expression in cells (e.g., cells of a subject). In some embodiments, the disclosure describes isolated nucleic acids engineered to express an inhibitory nucleic acid targeting endogenous SOD1 and an mRNA encoding a hardened SOD1 protein. In some embodiments, compositions and methods described by the disclosure are useful for treating Amyotrophic Lateral Sclerosis (ALS) in a subject.

Abstract: A method and a system for enhancing a user experience of an occupant in a vehicle that includes a step of detecting a change of the occupant's line of gaze and a step of outputting a notification, if a change of the occupant's line of gaze is detected or if a predetermined time period has elapsed. The notification is provided on an output device based on the detected occupant's line of gaze.

Abstract: The subject-matter relates to a charging box unit, comprising a base body, and a plug connection for the connection of one or more inputs and/or outputs, which is characterized in that the plug connection being arranged on an outwardly directed side of a base body of the charging box unit, wherein the plug connection is formed for connection to a corresponding socket connection of a charging station. Furthermore, the subject-matter relates to a charging station comprising an objective charging box unit.

Abstract: The invention relates to inhibitory nucleic acids and rAAV-based compositions, methods and kits useful for treating Amyotrophic Lateral Sclerosis.

Abstract: A method for magnetizing at least two magnets having different magnetic coercivities, includes the steps of: a) simultaneously exposing the at least two magnets to a first substantially homogeneous magnetic field having a predeterminable first field strength and a first magnetic field direction for completely magnetizing the magnets in the first magnetic field direction; b) simultaneously exposing the magnets magnetized in step a) to a second substantially homogeneous magnetic field having a predeterminable second field strength and a second magnetic field direction opposite to the first magnetic field direction such that the at least two magnets are differently magnetized.

Abstract: The invention is a simulation cabinet with two side walls, a bottom wall, a top wall, an exterior wall, and an interior chamber, with a rear wall being arranged in the interior chamber at a distance from the exterior wall, and at least one ventilator arranged between the rear wall and the exterior wall, with the rear wall showing air openings for suctioning air from the interior chamber via the ventilator, with the rear wall showing at least one opening and at least a first flow restrictor each being arranged between the rear wall and the exterior wall such that the air suctioned by the ventilator through the air openings of the rear wall, after flowing through the flow restrictor, can be guided through the opening into the interior.

Abstract: Disclosed is a process for purifying propylene oxide. A stream S0 containing propylene oxide, acetonitrile, water, and an organic compound containing one or more of acetone and propionaldehyde is provided. Propylene oxide is separated from S0 by subjecting S0 to distillation in a first distillation unit, obtaining a gaseous top stream S1c enriched in propylene oxide, a liquid bottom stream S1a enriched in acetonitrile and water, and a side stream S1b containing propylene oxide and enriched in the carbonyl compound; reacting the carbonyl compound in S1b with an organic compound containing an amino group to obtain a reaction product; separating propylene oxide from the reaction product in a second distillation unit, obtaining a gaseous top stream S3a enriched in propylene oxide and a liquid bottoms stream S3b enriched in the reaction product; and introducing stream S3a into the first distillation unit.

Abstract: A cable comprising a conductor surrounded by at least an inner semiconductive layer, an insulation layer and an outer semiconductive layer, in that order, wherein the insulation layer is not crosslinked or is cross-linked and comprises at least 90 wt % of a polymer composition, said polymer composition comprising: (I) 95.5 to 99.9 wt % of an LDPE; and (II) 0.1 to 4.5 wt % of an HDPE having a density of at least 940 kg/m3.

Abstract: A cable having one or more conductors surrounded by at least an inner semiconductive layer, an insulation layer and an outer semiconductive layer, in that order, wherein the insulation layer is not crosslinked and has at least 90 wt % of a polymer composition, said polymer composition having: (I) 85.0 to 99.5 wt % of an LDPE; and (II) 0.5 to 15.0 wt % of an HDPE having a density of at least 940 kg/m3 or 1.5 to 15.0 wt % of an ultra-high molecular weight polyethylene having a Mw of at least 1,000,000.

Abstract: A system for representing a vehicle cabin layout on an original scale comprising a plurality of projectors, a planar projection surface and a control system. The layout is loaded as digital cabin layout data into the control system and the layout comprises a first cabin aisle section extending along a first aisle axis. The projectors comprise vertical projectors spaced along a first projector axis. The control system drives the vertical projectors and processes cabin layout data loaded into the control system to project at least one section of the cabin layout on the planar projection surface on the original scale. That section of the layout which is projected by the vertical projectors comprises the first aisle section, such that the first aisle axis runs with the first projector axis in a first aisle plane extending perpendicular to the planar projection surface.

Abstract: The invention relates to a highly reactive, high-purity, free-flowing and dust-free lithium sulfide powder having an average particle size between 250 and 1,500 ?m and BET surface areas between 1 and 100 m2/g. The invention, furthermore, relates to a process for its preparation, wherein in a first step, lithium hydroxide monohydrate is heated in a temperature-controlled unit to a reaction temperature between 150° C. and 450° C. in the absence of air, and an inert gas is passed over or through it, until the residual water of crystallization content of the formed lithium hydroxide is less than 5 wt. % and in a second step, the anhydrous lithium hydroxide formed in the first step is mixed, overflowed or traversed by a gaseous sulfur source from the group consisting of hydrogen sulfide, elemental sulfur, carbon disulfide, mercaptans or sulfur nitrides.

Abstract: A data storage cartridge according to one embodiment comprises a housing configured to house a data storage medium, a sensor coupled to the housing, and a microcontroller coupled to the sensor. The microcontroller is configured to wirelessly communicate information about the sensor. Other embodiments relate to a data storage cartridge comprising a housing configured to house a data storage medium, a cartridge memory coupled to the housing, the cartridge memory having a wireless communications interface, and a microcontroller in physical communication with the cartridge memory. The microcontroller is configured to wirelessly communicate information retrieved from the cartridge memory.

Abstract: A semiconductor component may have a semiconductor body, an electrically conductive carrier layer, and an electrically poorly conductive insulation. The semiconductor body may include a first semiconductor layer and a second semiconductor layer, a first main face and a second main face, situated opposite the first main face, wherein the first main face is formed by a surface of the first semiconductor layer and the second main face is formed by a surface of the second semiconductor layer. The electrically conductive carrier layer may regionally cover the second main face the carrier layer is structured in such a way that it has at least one contact-free depression. The insulation may be located between the carrier layer and the semiconductor body and covers at least part of the second main face and extends up to at least one lateral face of the semiconductor body.

Abstract: The invention relates to a projectile (1), which has a projectile body (2) featuring a recess (5) for receiving an explosive, wherein the projectile body (2) has a rotation-symmetrical shell surface (7), at least in sections, which is surrounded, at least in sections, by several ring-shaped elements (8) provided with predetermined break points, wherein fragments (12) formed upon breakup of the elements (8) are predefined via the predetermined break points, said fragments (12) being connected to one another in a ring-shaped connecting portion (11) for forming the ring-shaped element (8), and the freely projecting ends (13) of the fragments (12) being at least partially arranged in a common orthogonal plane (13?) to a longitudinal axis (8?) of the ring-shaped element (8), wherein this orthogonal plane (13?) is arranged diverging from an orthogonal plane (11?) defined by the ring-shaped connecting portion (11), as well as to a corresponding ring-shaped element (8) for the projectile (1).

Abstract: A semiconductor laser includes a contact carrier having electrical contact surfaces to electrically contact a semiconductor layer sequence, an electrical connecting line from a main side of the semiconductor layer sequence facing away from the contact carrier and a plurality of capacitors, wherein the connecting line is located on or in the semiconductor layer sequence, at least two of the capacitors are present, the capacitances of which differ by at least a factor of 50, the capacitor having a smaller capacitance is configured to supply the active zone with current immediately after a switch-on operation, and the capacitor having the larger capacitance is configured to a subsequent current supply, the capacitor having the smaller capacitance directly electrically connects to the active zone, and a resistor is arranged between the capacitor having the larger capacitance and the active zone, the resistor having a resistance of at least 100 ?.

Abstract: The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency).

Abstract: A process for preparing a molding comprising zinc and a titanium-containing zeolitic material having framework type MWW, comprising (i) providing a molding comprising a titanium-containing zeolitic material having framework type MWW; (ii) preparing an aqueous suspension comprising a zinc source and the molding comprising a titanium-containing zeolitic material having framework type MWW prepared in (i); (iii) heating the aqueous suspension prepared in (ii) under autogenous pressure to a temperature of the liquid phase of the aqueous suspension in the range of from 100 to 200° C., obtaining an aqueous suspension comprising a molding comprising zinc and a titanium-containing zeolitic material having framework type MWW; (iv) separating the molding comprising zinc and a titanium-containing zeolitic material having framework type MWW from the liquid phase of the suspension obtained in (iii).

Abstract: A radiation emitting semiconductor chip is disclosed. In an embodiment, a radiation-emitting semiconductor chip includes a carrier including a first main surface and a second main surface opposite to the first main surface, an n-doped layer and a p-doped layer forming a pn-junction and a vertical region starting from the first main surface and running parallel to side faces of the carrier, wherein the vertical region is n-doped, p-doped or electrically insulating, and wherein the vertical region extends within a boundary region of the carrier and completely encloses a central volume region of the carrier, an epitaxial semiconductor layer sequence having an active zone configured to generate electromagnetic radiation during operation, the epitaxial semiconductor layer sequence being located at the first main surface of the carrier and two electrical contacts disposed on a front side of the semiconductor chip.

Abstract: Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (HTT) and methods of treating Huntington's disease using the same.

Abstract: A method for accessing filesystem objects on a backup server storing block level backups, includes: receiving a request to access a filesystem object stored in the block level backups, the request including a pattern of characters identifying the filesystem object in a global history table mapping a history of filesystem objects to the block level backups; identifying, based on the pattern of characters, an object identifier in the global history table corresponding to the filesystem object; identifying, based on the object identifier, a set of one or more block level backups of the computing system having a copy of the filesystem object; selecting a block level backup from the set of one or more block level backups; mounting the selected block level backup to access a backed-up file system of the computing system; and retrieving, from the backed-up filesystem, the filesystem object.