Abstract: According to an embodiment, a transducer package includes a circuit board including a port, a lid disposed over the port, an acoustic transducer disposed over the port and including a membrane, and an environmental transducer disposed at the circuit board in the port. The lid encloses a first region, and the membrane separates the port from the first region. Other embodiments include corresponding systems, apparatus, and structures, each configured to perform the actions or steps of corresponding embodiment methods.

Abstract: According to an embodiment, a method of sensing motion includes receiving a first signal from a first pressure sensor and a second signal from a second pressure sensor, comparing the first signal and the second signal, and characterizing a motion based on the comparing.

Abstract: A consumer device presentation unit is disclosed. The consumer device presentation unit includes at least a first electric consumer device including at least a first rechargeable energy storage; at least a first autonomous energy provision unit; and a charge module coupled at least to the first autonomous energy provision unit and the first electric consumer device.

Abstract: A head for an oral care implement has a mounting surface and at least one tuft mounted thereon. The tuft has a longitudinal axis and a cross-sectional area extending in a plane perpendicular to the longitudinal axis. The tuft comprises a plurality of substantially cylindrical filaments. Each filament has a longitudinal axis and a cross-sectional area extending in a plane that is perpendicular to the longitudinal axis. The cross-sectional area of an individual filament has a substantially non-circular shape. The plurality of filaments is arranged such that the cross-sectional area of the tuft has a scaled-up shape of the individual filament's cross-sectional area.

Abstract: An embodiment as described herein includes a microelectromechanical system (MEMS) with a first MEMS transducer element, a second MEMS transducer element, and a semiconductor substrate. The first and second MEMS transducer elements are disposed at a top surface of the semiconductor substrate and the semiconductor substrate includes a shared cavity acoustically coupled to the first and second MEMS transducer elements.

Abstract: Disclosed is an attenuated flavivirus live vaccine comprising a flavivirus mutant, characterized in that the flavivirus mutant has a deletion in the capsid protein of at least more than 4 successive amino acids, wherein the carboxy-terminal hydrophobic region is not affected by the deletion.

Abstract: The present invention relates to a mutant virus of the family flaviviridae, comprising a deletion in the capsid protein of at least 20 successive amino acids, without any further deletion, substitution or insertion mutation except of the amino acids next to the deletion, which may be substituted.

Abstract: A consumer device presentation unit is disclosed. The consumer device presentation unit includes at least a first electric consumer device including at least a first rechargeable energy storage; at least a first autonomous energy provision unit; and a charge module coupled at least to the first autonomous energy provision unit and the first electric consumer device.

Abstract: Linecards and methods for processing signals are provided.

Abstract: Nucleic acid immunisation is achieved by delivering a self-replicating RNA encapsulated within a small particle. The RNA encodes an immunogen of interest, and the particle may deliver this RNA by mimicking the delivery function of a natural RNA virus. Thus the invention provides a non-virion particle for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material encapsulating a self-replicating RNA molecule which encodes an immunogen. These particles are useful as components in pharmaceutical compositions for immunising subjects against various diseases.

Abstract: Disclosed is an attenuated flavivirus live vaccine comprising a flavivirus mutant, characterized in that the flavivirus mutant has a deletion in the capsid protein of at least more than 4 successive amino acids, wherein the carboxy-terminal hydrophobic region is not affected by the deletion.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.

Abstract: This application discloses self-replicating RNA molecules that contain modified nucleotides, compositions that contain the self-replicating RNA molecules, and methods for using the self-replicating RNA molecules, for example, to raise an immune response.

Abstract: Disclosed is an attenuated flavivirus live vaccine comprising a flavivirus mutant, characterised in that the flavivirus mutant has a deletion in the capsid protein of at least more than 4 successive amino acids, wherein the carboxy-terminal hydrophobic region is not affected by the deletion.

Abstract: The present invention relates to a mutant virus of the family flaviviridae, comprising a deletion in the capsid protein of at least 20 successive amino acids, without any further deletion, substitution or insertion mutation except of the amino acids next to the deletion, which may be substituted.

Abstract: Linecards and methods for processing signals are provided.

Abstract: A tinted mirror which has been treated to reflect a modified image of skin is used to allow a subject to consider a potential change of the appearance of his/her skin, which would follow from the application of a cosmetic product such as self-tanning product. The mirror may be tinted with a brown hue so as to reflect an image that corresponds to the change of coloration of skin after the application of a self-tanning product. The invention may be used in beauty parlor or supermarket aisle to help a subject visualize the potential effect of a self-tanning product on his/her skin.

Abstract: An improved method and a corresponding device for adapting the data rate of a data stream by using a FIFO memory (1) into which data packets of the data stream are written at a first data rate and from which the data packets are output at a second data rate, is proposed. According to the invention a certain pause (TP) is inserted after each output data packet until the next data packet is output. In the event of a no-load of the FIFO memory (1) an additional pause (TFE) is produced, which is detected. In addition, the number of the data packets output between a preceding no-load and the current no-load of the FIFO memory (1) is ascertained.

Abstract: Disclosed is an attenuated flavivirus live vaccine comprising a flavivirus mutant, characterised in that the flavivirus mutant has a deletion in the capsid protein of at least more than 4 successive amino acids, wherein the carboxy-terminal hydrophobic region is not affected by the deletion.