Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Abstract: One embodiment of the present invention sets forth a technique for generating audio for a speaker system. The technique includes receiving an audio input signal, a first location associated with the audio input signal, a first geometric model of the speaker system, and a second geometric model of one or more surfaces in proximity to the speaker system. The technique also includes generating a plurality of output signals for a plurality of speaker drivers in the speaker system based on the audio input signal, the first location, and the first and second geometric models. The technique further includes transmitting the plurality of output signals to the plurality of speaker drivers, wherein the plurality of speaker drivers emit audio that corresponds to the plurality of output signals, the emitted audio rendering a sound corresponding to the audio input signal at the first location.

Abstract: A speaker system is provided with a housing adapted to mount to a support. A driver is supported by the housing and arranged to project sound about a first axis extending at an offset angle relative to a longitudinal axis extending from the housing. A waveguide extends from the driver to define a cavity extending along the first axis. The waveguide includes a first segment formed at a first angle relative to the longitudinal axis, and a second segment formed at a second angle relative to the longitudinal axis, wherein the second segment is arranged opposite the first segment and the second angle is greater than the first angle to collectively provide an asymmetrical sound pattern in a first plane.

Abstract: A speaker system is provided with a housing adapted to mount to a support. A driver is supported by the housing and arranged to project sound about a first axis extending at an offset angle relative to a longitudinal axis extending from the housing. A waveguide extends from the driver to define a cavity extending along the first axis. The waveguide includes a first segment formed at a first angle relative to the longitudinal axis, and a second segment formed at a second angle relative to the longitudinal axis, wherein the second segment is arranged opposite the first segment and the second angle is greater than the first angle to collectively provide an asymmetrical sound pattern in a first plane.

Abstract: A mounting system for mounting a loudspeaker to a substrate includes a mounting assembly having an elongated screw, a support member received on and movable along the screw, and a mounting arm rotatably connected to the support member and having a resting position and a working position. A guide housing receives the mounting assembly with the screw extending longitudinally therethrough and includes a wall structure with an open front side and a cap at a top portion of the wall structure. In the resting position, the support member is positioned along the screw at least partially received within the cap and the mounting arm is substantially contained within the wall structure. In the working position, the support member is positioned along the screw to be outside of the cap and the mounting arm is spring-biased away from the screw and extends outwardly through the front side of the wall structure.