Abstract: The present invention relates generally to strain typing of Escherichia coli TY2482 and/or LB226692, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis. In particular embodiments, a genetic detection assay (e.g., SNP detection assay, sequencing, etc.) is used to identify mutations in the aggregative adherence fimbria I gene cluster fimbrial subunit (aggA) gene to identify the TY2482 strain, including mutations at position 103, 158, 188, 191, 197, and 271.

Abstract: The present invention provides oligonucleotide primers and compositions and kits containing the same for rapid identification of bacteria by amplification of a segment of bacterial nucleic acid followed by molecular mass analysis.

Abstract: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses (e.g., swine-origin influenza A (H1N1) virus) which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.

Abstract: The present invention provides a method for rapid identification and quantitation of bacteria by amplification of a segment of bacterial nucleic acid followed by analysis by mass spectrometry. The compositions provide for characterization of the molecular masses and base compositions of bacterial nucleic acids which are used to rapidly identify bacteria.

Abstract: The present invention relates generally to the identification of Streptococcus pneumoniae, such as antibiotic resistant Streptococcus pneumoniae, and provides methods, compositions, kits and systems useful for this purpose when combined, for example, with molecular mass or base composition analysis.

Abstract: The present invention provides compositions, kits and methods for rapid genotyping of strains of Mycobacterium tuberculosis by molecular mass and base composition analysis. Drug-resistant strains of Mycobacterium tuberculosis may be identified in human clinical samples and as such, provide for methods of treatment of humans infected with drug resistant strains of Mycobacterium tuberculosis.

Abstract: The present invention provides compositions, kits and methods for rapid identification and quantification of strains of hepatitis C viruses by molecular mass and base composition analysis.

Abstract: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of bacterial bioagents and populations of bioagents which are members of the Staphylococcus bacterial genus by amplification of a segment of bioagent nucleic acid followed by molecular mass analysis.

Abstract: The present invention provides oligonucleotide primers and compositions and kits containing the same for rapid identification of bacteria by amplification of a segment of bacterial nucleic acid followed by molecular mass analysis.

Abstract: The present invention provides design and synthesis of oligomeric compounds and compositions that can be administered to reduce the activity of SARS virus in vivo or in vitro, to prevent or treat SARS virus-associated disease, to detect AARS virus, and to diagnose SARS virus-associated diseases.

Abstract: The method described herein relate generally the identification of bioagents on the basis of base composition signatures for bioagent-identifying amplicons. Specifically, methods of the present invention are directed to the application of pattern recognition models, particularly probability pattern classifiers, to the identification of both known and previously unrecognized bioagents. In certain embodiments, the pattern classifiers relate to probability cloud patterns, such as mutational probability patterns. In other embodiments the pattern classifiers relate to polytope pattern models.

Abstract: The present invention provides a method for rapid identification and quantitation of bacteria by amplification of a segment of bacterial nucleic acid followed by analysis by mass spectrometry. The compositions provide for characterization of the molecular masses and base compositions of bacterial nucleic acids which are used to rapidly identify bacteria.

Abstract: Polynucleotides comprising molecular interaction sites of 16S rRNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatorial libraries of compounds that bind thereto are also provided. Method of modulating the activity of 16S rRNA by contacting 16S rRNA or prokaryotic cells containing the same with a compound identified by such virtual or actual screening are also provided.

Abstract: The present invention provides design and synthesis of oligomeric compounds and compositions that can be administered to reduce the activity of SARS virus in vivo or in vitro, to prevent or treat SARS virus-associated disease, to detect AARS virus, and to diagnose SARS virus-associated diseases.