Abstract: A solution packaging system and method of administering a solution are disclosed. One embodiment of the solution packaging system of the present invention comprises a gas-impermeable dual-chamber bag, having a first chamber and a second chamber separated by a frangible (releasable) seal, and an over-wrap member enclosing and containing the dual-chamber inner bag. The dual-chamber bag can be used to package two-part medicinal solutions containing bicarbonate, such as ophthalmic irrigation solutions. The first chamber can be filled with and contain a first part of such an irrigation solution, comprising, for example, a buffer such as bicarbonate. The second chamber can contain the second part of such a solution, comprising, for example, glutathione (GSSG), or other anti-oxidant, and dextrose, or other energy source. Both parts may contain other excipients.