Abstract: Injection systems for drug delivery are disclosed. A system may include a container filled or fillable with a drug, a stopper movably disposed in the container, a plunger, an energy source outputting a force, a mechanical linkage operable to transmit the force output by the energy source to the plunger to cause the plunger to act on the stopper to expel the drug from the container, and a trigger member. The system may have pre-injection state where the trigger member inhibits actuation of the mechanical linkage, an injection state where the trigger member permits actuation of the mechanical linkage, and a post-injection state where the plunger is stationarily positioned in an end-of-dose position. The system may be designed to limit the number of components included in various force transmission loops present in the pre-injection, injection, and/or post-injection states.

Abstract: In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: An illustrative method includes receiving, in response to a storage query sent to a plurality of storage nodes of a data storage system to inquire as to which of the storage nodes can store data, a plurality of responses from a subset of storage nodes included in the plurality of storage nodes, the responses including an indication as to whether any of the storage nodes included in the subset is already storing additional data having a data identifier included in the storage query; renaming, based on a particular storage node included in the subset indicating that the particular storage node is already storing the additional data, the data; selecting, based on the responses, multiple storage nodes included in the subset; and sending the data and the data identifier to the selected storage nodes for storage by the selected storage nodes.

Abstract: In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: We report improved adjuvant compounds that have an aryl 2-aminoimidazole structure for macrolide potentiation against a virulent strain of gram-negative bacteria, AB5075. Compounds were discovered to retain significant adjuvant activity at 10 ?M, lowering the minimum inhibitory concentration (MIC) of clarithromycin (CLR) from 8-fold to 128-fold or greater. 2-Aminoimidazole compounds linked to aryl groups via either an amide or urea linker showed significantly improved activity over control compounds.

Abstract: In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Tryptamine ureas and derivatives function as adjuvants to sensitize gram-negative bacteria to the effects of polymyxin antibiotics (e.g., colistin). Combination therapy of polymyxin antibiotics and the adjuvants has utility in the treatment of gram-negative bacterial infection, including treatment of drug-resistant strains.

Abstract: Provided are 2-aminoimidazole-phenyl derivative compounds of Formula (I): which compounds are useful in methods of controlling microbial growth, such as by enhancing the effects of an antibiotic administered in combination with the compound. Compositions including these compounds, devices including these compounds, and methods of using the same are also provided.

Abstract: An illustrative method includes receiving, in response to a storage query sent to a plurality of storage nodes of a data storage system to inquire as to which of the storage nodes can store data, a plurality of responses from a subset of storage nodes included in the plurality of storage nodes, the responses including an indication as to whether any of the storage nodes included in the subset is already storing additional data having a data identifier included in the storage query; renaming, based on a particular storage node included in the subset indicating that the particular storage node is already storing the additional data, the data; selecting, based on the responses, multiple storage nodes included in the subset; and sending the data and the data identifier to the selected storage nodes for storage by the selected storage nodes.

Abstract: Infections caused by multidrug-resistant (MDR) bacteria, particularly Gram-negative bacteria, are an escalating global t health threat. Often clinicians are forced to administer the last resort antibiotic colistin, however colistin resistance is becoming increasingly prevalent, giving rise to the potential for a situation in which there are no treatment options for MDR Gram-negative infections. The development of adjuvants that circumvent bacterial resistance mechanisms is a promising orthogonal approach to the development of new antibiotics. We recently disclosed that the known IKK-13 inhibitor IMD-0354 potently suppresses colistin resistance in several Gram-negative strains. In this disclosure, we explore the structure activity relationship (SAR) between the IMD-0354 scaffold and colistin resistance suppression, and identify several compounds with more potent activity than the parent against highly colistin resistant strains of Acinetobacter baumannii and Klebsiella pneumoniae.

Abstract: An exemplary method includes sending a storage query to a plurality of storage nodes of a data storage system, the storage query including a data identifier of a data instance and an inquiry as to which of the storage nodes can store the data instance; receiving, in response to the storage query, a plurality of responses from a subset of storage nodes included in the plurality of storage nodes and that have at least a predetermined minimum amount of free storage space, the responses including information about each of the storage nodes included in the subset; selecting, based on the information included in the responses, multiple storage nodes included in the subset; and sending the data instance and the data identifier to the selected storage nodes for storage by the selected storage nodes.

Abstract: An example method includes receiving a request to store a data item within a directory of a file structure layer for an unstructured storage layer of a data storage system; providing an identifier of a collection object representative of the directory and stored within the unstructured storage layer; sending to a plurality of storage nodes included in a cluster of the data storage system, a query as to which of the storage nodes are available to store the data item; receiving, in response to the query, replies from a subset of storage nodes that are included in the plurality of storage nodes and that are available to store the data item; selecting, based on the replies, a storage node from the subset of storage nodes; and transmitting the data item to the selected storage node for storage by the selected storage node within the unstructured storage layer.

Abstract: An exemplary method includes receiving a request to store a data item within a directory of a virtual file structure layer for an unstructured storage layer of a data storage system, caching an identifier of a collection object representative of the directory, sending a query to a plurality of storage nodes included in a cluster of the data storage system, receiving, in response to the query, replies from a subset of the storage nodes that are available to store the data item, selecting, based on the replies, a storage node from the subset of storage nodes, transmitting the data item to the selected storage node for storage by the selected storage node within the unstructured storage layer, accessing, based on the cached identifier, the collection object, and updating the collection object to include a reference to the data item stored in the selected storage node.

Abstract: Provided are 2-aminoimidazole-phenyl derivative compounds of Formula (I): which compounds are useful in methods of controlling microbial growth, such as by enhancing the effects of an antibiotic administered in combination with the compound. Compositions including these compounds, devices including these compounds, and methods of using the same are also provided.

Abstract: Provided herein is a method to treat a Gram-negative bacterial infection in a subject in need thereof, comprising administering a compound of Formula I: in combination with a Gram-positive antibiotic to said subject in a treatment-effective amount. Also provided is a method to control Gram-negative bacteria, comprising applying a compound of Formula I in combination with a Gram-positive antibiotic in a Gram-negative bactericidal-effective amount.

Abstract: There is provided a method and server for retrieving data from a data storage system including a plurality of storage nodes. The method may include sending a multicast message to at least a subset of the storage nodes. The multicast message may include a request for the subset of storage nodes to send the data. The multicast message may further include a data identifier indicating the data to be retrieved. Moreover, the method may include receiving data from a first storage node of the subset of storage nodes. The data received from the first storage node may correspond to the requested data. At least the act of sending a multicast message or the act of receiving data from the first storage node may be performed on a condition that an estimated size of the data is less than a predetermined value.

Abstract: In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: An exemplary method includes identifying, within a first data item stored in a data storage system, a reference to a second data item stored in the data storage system, determining, based on the reference, that a storage location of the second data item is within a cluster of storage nodes included in the data storage system, sending, based on the determining that the storage location of the second data item is within the cluster of storage nodes, a request for the second data item to the storage nodes included in the cluster, and receiving, based on the request, the second data item from a particular storage node included in the cluster.

Abstract: A method for maintaining a data storage system is disclosed. The method may include monitoring for receipt of a first broadcast message from a first data storage node, where the first broadcast message may indicate that the first data storage node is operating correctly. The method may also include detecting that the first data storage node is malfunctioning based on not receiving the first broadcast message for a predetermined period of time. The method may also include initiating a data replication procedure based on detecting that the first data storage node is malfunctioning. The data replication procedure may include sending a first multicast message to a plurality of data storage nodes requesting identification of a second data storage node that maintains a copy of a file stored on the first data storage node.

Abstract: There is provided a method and server for retrieving data from a data storage system including a plurality of storage nodes. The method may include sending a multicast message to at least a subset of the storage nodes. The multicast message may include a request for the subset of storage nodes to send the data. The multicast message may further include a data identifier, indicating the data to be retrieved. Moreover, the method may include receiving data from a first storage node of the subset of storage nodes. The data received from the first storage node may correspond to the requested data. At least the act of sending a multicast message or the act of receiving data from the first storage node may be performed on a condition that an estimated size of the data is less than a predetermined value.