Abstract: In a method for manufacturing a wrap-around tube from at lest one strip-shaped material, the wrapping is brought about by at least one rotating wrapping element which is indirectly or directly in engagement with the wrap-around tube, and the strip-shaped material is wrapped onto a stationary wrapping core. An apparatus for manufacturing a wrap-around tube from at least one strip-shaped material is distinguished by the fact that it has a rotating wrapping element, which is indirectly or directly in engagement with the wrap-around tube, and a stationary wrapping core, onto which the at least one strip-shaped material is wrapped.

Abstract: The present invention relates to a process for preparing a cyclic ketone having from 7 to 16 carbon atoms, which comprises at least the steps (a) oxidation of a composition (I) comprising at least one cyclic olefin which has from 7 to 16 carbon atoms and at least one C—C double bond by means of dinitrogen monoxide to give a composition (A), (b) treatment of the composition (A) with at least one base to give a composition (B).

Abstract: The present invention concerns a device for generating a thermal flux with a magneto-caloric material, which is non-polluting, effective, reliable, of simple design and simple to use, economical, compact, and can be used both in large-scale industrial installations and for domestic applications. The device (3) for generating thermal flux with a magneto-caloric material comprises two thermal flux generation units (30) arranged side by side and each provided with thermal bodies (31) containing a magneto-caloric element and arranged in line along two rows carried by rectilinear frames (306). The thermal bodies (31) are subjected in alternation to magnetic fields emitted by magnetic mechanism (303) in the shape of a U, positioned in a staggered arrangement on either side of two bars (304) which move in reciprocating rectilinear translation. The thermal bodies (31) have a through-channel containing a heat transfer fluid and connected to one or more heat transfer fluid circuits.

Abstract: The present disclosure provides a method that efficiently produces (6R)-tetrahydrobiopterin in high yield and purity. The method includes the step of hydrolyzing diacetylbiopterin to biopterin under basic conditions in a biphasic mixture comprising an organic phase and an aqueous phase. After substantially complete hydrolysis of diacetylbiopterin, the aqueous phase containing biopterin can be separated from the organic phase containing most of the organic impurities, which avoids the time-consuming step of isolating biopterin as a solid. The aqueous solution containing biopterin is stereoselectively hydrogenated to (6R)-tetrahydrobiopterin under basic conditions and high hydrogen pressure in the presence of a metal catalyst (e.g., a platinum catalyst). To improve the purification of an acid addition salt of (6R)-tetrahydrobiopterin (e.g., (6R)-tetrahydrobiopterin dihydrochloride), any residual salts (e.g.

Abstract: The present invention relates to a pharmaceutical combination product for cancer therapy. The combination product comprises the two active ingredients glutaminase and 6-diazo-5-oxo-L-norleucine (DON). The invention further relates to the use of such a combination product for the treatment of cancers.

Abstract: The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing one member of the collection, which encodes a distinct member of a polyclonal protein. The cells are cultured under suitable conditions for expression of the polyclonal protein, which is obtained from the cells or culture supernatant. The nucleic acid sequence is introduced into the cells by transfection with a collection of vectors. The present method is suitable for manufacturing recombinant polyclonal antibodies for therapeutic uses.

Abstract: An electromotive linear drive with a drive unit having a drive motor and a spindle driven by the drive unit. The drive includes a spindle nut disposed on the spindle. The spindle nut is movable longitudinally on the spindle. A lifting tube is operatively connected to the spindle nut so that the spindle nut moves together with the lifting tube. A connecting part is disposed on a free end of the lifting tube. A braking assembly is disposed in the lifting tube and is operatively connected to the spindle nut via an adjustable, frictional connection. The braking assembly is manipulable. During operation of the drive motor, the spindle nut frictionally engages the braking assembly, preventing rotation of the spindle nut. The frictional connection may be adjusted to permit the spindle nut to rotate with respect to the spindle, thereby manipulating a linear speed component of the lifting tube.

Abstract: The invention relates to a method for the control of the movement course of an object (23) represented on a display device (12), which within the framework of a ball game or sport event simulated by a computation unit (11) is to move from a starting point (16) into another region of the environment indicated on the display device (12).

Abstract: The present invention concerns a device for generating thermal units using magnetocaloric material, with low energy consumption, evolutive, of a simple design, reliable operation, which allows to generate thermal units in a cost effective way while at the same time removing the risks of thermal fluid leakage and limiting the number of mechanical parts. The device (1a) for generating thermal units using magnetocaloric material comprises a magnetic element (2a) coupled to a power supply (3a), a magnetocaloric element (4a), a circuit (5) for thermal exchange fluid in which one or more thermal exchange fluids are made to circulate by means of circulation (6), and two heat exchangers (7, 8). The power supply (3a) is set up to generate electric pulses so as to create an impulsive magnetic field that causes the heating and the cooling of the magnetocaloric element (4a) and hence of the thermal exchange fluid.

Abstract: Systems and methods are described for controlling the performance of an avatar in an electronic game. The avatar is equipped with a virtual metabolism that includes one or more metabolic parameters, which simulate real-life metabolic processes. Actions implemented by a user playing the electronic game cause changes in the metabolic parameters which affects and controls the performance of the avatar in virtual athletic activities. The electronic game can further include both real-life and virtual items available for purchase by the user to enhance the user's and the avatar's athletic performance.

Abstract: An integrated circuit includes a memory interface circuit. The memory interface circuit includes a first interface channel configured to couple to at least one memory device, a second interface channel configured to couple to at least one memory device, and a multiplexer configured to select between the first interface channel and the second interface channel.

Abstract: The present invention relates to a process for purifying a composition (I) at least comprising cyclododecanone. The process according to the invention for purifying a composition (I) at least comprising cyclododecanone comprises at least step (i) (i) irradiation of the composition (I).

Abstract: The present invention proposes a thermal generator which is non-polluting, has very good energy efficiency, is of simple and economical design and uses little energy, at the same time as being capable of further development, flexible and modular. In this thermal generator (1), the thermal elements (3) composed of magneto-calorific material each comprises two separate collector circuits (31 and 32), a “hot” collector circuit connected to a hot heat transfer fluid circuit (51) and a “cold” collector circuit (32) linked to a cold heat transfer fluid circuit (52). The heat transfer fluid is made to move alternately in one or the other of the collector circuits (31 and 32) depending on whether or not the thermal elements (3) are subjected to the magnetic field generated by the magnets (40) moving in rotation around a central axis (B) with respect to the thermal elements (3).

Abstract: The invention relates to a heat generator comprising a magneto-caloric material and a method for generating efficient and reliable thermies enabling of substantially limiting displaceable inert masses in order to produce a magnetic field variation required for obtaining a magneto caloric effect and usable by individuals and/or industries. The inventive generator (10) comprises magneto caloric thermal elements (Ti) which are circularly arranged and crossed by conduits containing coolant flowing therethrough and magnetic elements (Gi) exposing the thermal elements (Ti) to a magnetic field action. The generator (10) also comprises magnetic divergence (mj) elements arranged between the thermal elements (Ti) and the magnetic elements (Gi) and coupled to displacement mechanism (not represented) for moving from one thermal element (Ti) to another thermal element (Ti+1) and initiating the magnetic flux variation in the thermal elements (Ti), thereby promoting the calorie and/or frigorie generation.

Abstract: The present application relates to a process for reacting a composition I comprising at least one aldehyde with hydrogen in the presence of a catalyst in at least one main reactor and at least one postreactor, wherein at least 50% of the fresh hydrogen fed to the reaction system is fed into at least one postreactor. In a preferred embodiment, composition I comprises at least one further organic compound.

Abstract: The invention relates to a process for preparing isocyanates, which comprises the (1) preparation of a crude MDA mixture by reaction of aniline with formaldehyde, (2) separation of the crude MDA mixture into MMDA and PMDA, (3a) phosgenation of the PMDA separated off in step 2 in the liquid phase to form PMDI and (3b) phosgenation of the MMDA separated off in step 2 in the gas phase to form MMDI.

Abstract: The invention relates to a process for preparing isocyanates, which comprises the steps (1) preparation of a crude MDA mixture by reaction of aniline with formaldehyde, with the reaction conditions being selected so that the resulting crude MDA can be converted completely into the gas phase, (2) conversion of the crude MDA mixture from step (1) into the gas phase and (3) phosgenation of crude MDA in the gas phase to give MMDI and PMDI.

Abstract: The removal of partial areas of a coating (11, 12) on at least one surface (37, 38) of a glass pane (2) takes place by means of a plasma jet (14, 15) which emerges from a plasma nozzle (5, 6). The plasma nozzle (5, 6) is part of a plasma unit and two such plasma units are provided. Both of the plasma nozzles (5, 6) are oriented towards each other and form a pair of nozzles. A glass pane (2) is machined between both of the nozzles (5, 6). A distance sensor (23, 24) is arranged on both of the nozzles (5, 6), and said nozzles (5, 6) are positioned at the correct distance in relation to the surface (37, 38) of the glass pane (2).

Abstract: An electric circuit for providing a selection signal being used to select a control value of a control variable which oscillates, at steady state, about a reference value about a first control value and a second control value with a first period duration comprises a first differential circuit which provides a first current being dependent on a difference between the first control value and the reference value. The electric circuit further comprises a second differential circuit which provides a second current being dependent on a difference between the reference value and the second value and a first node at which a differential current between the first current and the second current is formed. The differential current forms the selection signal indicating if the first control value or the second value is to be selected in order to minimize a difference between the reference signal and control variable.

Abstract: An ophthalmologic surgical work station has a microscope and a foot switch corresponding thereto. The microscope is connected to the foot switch via a console. The microscope and the foot switch are coarsely prepositioned and a change of the relative position between the microscope and the foot switch with respect to each other is only possible via a fine positioning.