Abstract: A surgical device comprising: a closure assembly including: (a) a latch unit comprising: (A) a hook latch, having a home position, (B) a forward bias constraint, (C) a rearward bias constraint, and (D) a bias member extending between the forward bias constraint and the rearward bias constraint so that the bias member has a pre-load when the hook latch is in the home position; (b) a movement unit including a bar that is movable relative to the latch unit so that the bar is movable in a prescribed motion into contact with the latch unit to create a locked state; and wherein the bar moves into contact with the hook latch driving the hook latch in a first direction, away relative to the home position, and then the hook latch is moved by the bar in a second direction relative to the home position, and a loading of the bias member is increased from the pre-load when the hook latch is moved in either the first direction away from the home position or the second direction away from the home position.

Abstract: This invention is a system for the production of biomass from photosynthesizing microorganisms that includes a photobioreactor comprising a transparent panel made from two transparent sheets with a separation between them, with top and bottom openings and with transparent, parallel subdivisions that form a panel of vertically arranged, transparent cells, where each transparent cell has a top opening and a bottom opening; a lower recirculation chamber in fluid contact with the bottom openings of the transparent panel; an upper recirculation chamber in fluid contact with the top openings of the transparent panel; a gas distribution tube externally arranged along the edge of said transparent panel; where said gas distribution tube comprises gas injectors arranged in fluid contact with the interior of a plurality of transparent cells; and a supporting structure that supports the transparent panel, the lower recirculation chamber, the upper recirculation chamber and the air distribution tube.

Abstract: Embodiments include an apparatus and method for building courses. For example, one embodiment of a course builder apparatus comprises: a course builder application to retrieve data from a database, the data usable for constructing one or more online courses; a graphical user interface (GUI) of the course builder application for designing an online course, the GUI comprising: a template region in which one or more published classroom activity templates and/or step templates are graphically displayed; an editing region into which a designer of a course may select and drag one or more of the published classroom activity templates or step templates, the editing region comprising one or more fields or other graphical elements to allow the designer may edit the one or more published classroom activity templates or step templates.

Abstract: Embodiments include an apparatus and method for building courses. For example, one embodiment of a course builder apparatus comprises: a course builder application to retrieve data from a database, the data usable for constructing one or more online courses; a graphical user interface (GUI) of the course builder application for designing an online course, the GUI comprising: a template region in which one or more published classroom activity templates and/or step templates are graphically displayed; an editing region into which a designer of a course may select and drag one or more of the published classroom activity templates or step templates, the editing region comprising one or more fields or other graphical elements to allow the designer may edit the one or more published classroom activity templates or step templates.

Abstract: Provided herein are compounds of Formula (I) or (II): (I) (II) pharmaceutically acceptable salts, tautomers, prodrugs, and stereoisomers thereof, and pharmaceutical compositions thereof, wherein X, RN, R1, R3, R4, p, and m are as defined herein. Such compounds and compositions have been found useful in the treatment or prevention of viral infections, e.g., polyomaviral infections, and are further envisioned useful in treatment or prevention of other pathogenic conditions associated with endosomal trafficking. Methods of treating or preventing an infection by a pathogen secreting an AB5 toxin is also contemplated.

Abstract: Provided herein are compounds of Formula (I) or (II): (I) (II) pharmaceutically acceptable salts, tautomers, prodrugs, and stereoisomers thereof, and pharmaceutical compositions thereof, wherein X, RN, R1, R3, R4, p, and m are as defined herein. Such compounds and compositions have been found useful in the treatment or prevention of viral infections, e.g., polyomaviral infections, and are further envisioned useful in treatment or prevention of other pathogenic conditions associated with endosomal trafficking. Methods of treating or preventing an infection by a pathogen secreting an AB5 toxin is also contemplated.

Abstract: This invention is a system for the production of biomass from photosynthesizing microorganisms that includes a photobioreactor comprising a transparent panel made from two transparent sheets with a separation between them, with top and bottom openings and with transparent, parallel subdivisions that form a panel of vertically arranged, transparent cells, where each transparent cell has a top opening and a bottom opening; a lower recirculation chamber in fluid contact with the bottom openings of the transparent panel; an upper recirculation chamber in fluid contact with the top openings of the transparent panel; a gas distribution tube externally arranged along the edge of said transparent panel; where said gas distribution tube comprises gas injectors arranged in fluid contact with the interior of a plurality of transparent cells; and a supporting structure that supports the transparent panel, the lower recirculation chamber, the upper recirculation chamber and the air distribution tube.

Abstract: Systems, methods and apparatus provide a character process for processing markup language data, such as XML data, by receiving a character stream of markup language data and applying sequences of characters of the character stream to a set of state machines. The set of state machines includes a plurality of construct state machines responsible for processing respective markup language constructs identified by the sequences of characters. The character processor produces, from application of the sequences of characters to the set of state machines, an intermediate representation of the markup language constructs identified by the sequence of characters of the character stream of markup language data. The intermediate representation contains encoded items containing type, length, value representations representative of constructs within the character stream of markup language data.

Abstract: A markup language processing device processes markup language messages by receiving a message containing portions of tagged data formatted in a markup language and applying a transform selection rule set to at least one tagged rule selection data portion in the message to select at least one markup language transformation to apply to the tagged pre-transform data portion within the message. The markup language processing device applies the selected markup language transformation to transform the tagged pre-transform data portion to a tagged post-transform data portion according to a transformation function and then conditionally forwards the message. The markup language processing device operates on behalf of a computerized device that is not required to process the message due to operation of the at least one markup language transformation within the markup language processing device.

Abstract: A high level transformation method and apparatus for converting data formats in the context of network applications, among other places. A flexible transformation mechanism is provided that facilitates generation of translation machine code. A translator is dynamically generated by a translator compiler engine. When fed an input stream, the translator generates an output stream by executing the native object code generated on the fly by the translator compiler engine. In addition, the translator may be configured to perform a bi-directional translation between the two streams as well as translation between two distinct protocol sequences. Further a translator may working in streaming mode, to facilitate streaming processing of documents.

Abstract: A representation of a markup language data such as XML expressed as a sequence of encoded items provides a data format including a type field containing i) a construct type identifying a type of markup language data construct to which the encoded item corresponds or, ii) a directive type identifying directive information concerning a processing characteristic associated with the sequence of encoded items. If the type field contains a construct type, the encoded item includes i) a length field containing a size of construct data associated with the markup language data construct to which the encoded item corresponds and ii) a value field identifying construct data associated with the markup language data construct to which the encoded item corresponds. For a directive type, the encoded item includes a directive value supplementing the directive information concerning a processing characteristic associated with the sequence of encoded items.

Abstract: A methodology and related system apparatus is provided for using and coordinating the use of information conveyed over communications to most efficiently and flexibly respond to abnormalities to reconfigure and restore service to end customers in commodity distribution systems in a manner to enhance the reconfigurability of the distribution system, e.g. circuit reconfiguration in an electrical power distribution system. Methodology is also provided to appropriately allocate system resources of the distribution system when so desired, e.g. to prevent the potential overloading of electrical power sources. In one illustrative arrangement, the methodology is characterized by resources at each node and communications of source allocation data or messages to other nodes to request and establish an appropriate allocation of system resources.

Abstract: A markup language processing device processes markup language messages by receiving a message containing portions of tagged data formatted in a markup language and applying a transform selection rule set to at least one tagged rule selection data portion in the message to select at least one markup language transformation to apply to the tagged pre-transform data portion within the message. The markup language processing device applies the selected markup language transformation to transform the tagged pre-transform data portion to a tagged post-transform data portion according to a transformation function and then conditionally forwards the message. The markup language processing device operates on behalf of a computerized device that is not required to process the message due to operation of the at least one markup language transformation within the markup language processing device.

Abstract: A representation of a markup language data such as XML expressed as a sequence of encoded items provides a data format including a type field containing i) a construct type identifying a type of markup language data construct to which the encoded item corresponds or, ii) a directive type identifying directive information concerning a processing characteristic associated with the sequence of encoded items. If the type field contains a construct type, the encoded item includes i) a length field containing a size of construct data associated with the markup language data construct to which the encoded item corresponds and ii) a value field identifying construct data associated with the markup language data construct to which the encoded item corresponds. For a directive type, the encoded item includes a directive value supplementing the directive information concerning a processing characteristic associated with the sequence of encoded items.

Abstract: Systems, methods and apparatus provide a character process for processing markup language data, such as XML data, by receiving a character stream of markup language data and applying sequences of characters of the character stream to a set of state machines. The set of state machines includes a plurality of construct state machines responsible for processing respective markup language constructs identified by the sequences of characters. The character processor produces, from application of the sequences of characters to the set of state machines, an intermediate representation of the markup language constructs identified by the sequence of characters of the character stream of markup language data. The intermediate representation contains encoded items containing type, length, value representations representative of constructs within the character stream of markup language data.

Abstract: A high level transformation method and apparatus for converting data formats in the context of network applications, among other places. A flexible transformation mechanism is provided that facilitates generation of translation machine code. A translator is dynamically generated by a translator compiler engine. When fed an input stream, the translator generates an output stream by executing the native object code generated on the fly by the translator compiler engine. In addition, the translator may be configured to perform a bi-directional translation between the two streams as well as translation between two distinct protocol sequences. Further a translator may working in streaming mode, to facilitate streaming processing of documents.

Abstract: This invention provides novel polypeptides that modulate activities of the replication and transcription activator (RTA) of Kaposi's sarcoma-associated herpesvirus (KSHV). The invention also provides methods for screening modulators of RTA activities. The methods comprise first screening test agents for modulators of an RTA-modulatory polypeptide and then further screening the identified modulating agents for modulators of RTA activities. The invention further provides methods and pharmaceutical compositions for treating diseases and conditions associated with infections of gammaherpesviruses.