Patents by Inventor Christian Noti

Christian Noti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of 3,5-dioxo hexanoate ester in two steps
    Patent number: 9296718
    Abstract: The invention discloses a method for the preparation of tert-butyl 6-chloro-3,5-dioxohexanoate from Meldrum's acid derivative and its use for the preparation of tert-butyl (4R,6S)-(6-hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetate (BHA), Rosuvastatin and Atorvastatin.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: March 29, 2016
    Assignee: Lonza Ltd
    Inventors: Christian Noti, Guixian Hu, Barry Jackson
  • Process for the preparation of (1,4)-2-oxa-3-azabicyclo[2,2.1]hept-5-enes
    Patent number: 9102634
    Abstract: Enantiomerically enriched (1 S,4R)-2-oxa-3-azabicyclo[2.2.1]hept-5-ene of formula wherein PG1 is an amino-protective group, are prepared from cyclopentadiene via hetero-Diels-Alder cycloaddition with protected 1-C-nitroso-?-D-ribofuranosyl halides of formula wherein X is a halogen atom selected from fluorine, chlorine, bromine and iodine, PG2 is a hydroxyl-protective group and PG3 is a 1,2-diol-protective group.
    Type: Grant
    Filed: August 25, 2010
    Date of Patent: August 11, 2015
    Inventors: Manuela Franzen, Christian Noti
  • Preparation of 3,5-Dioxo Hexanoate Ester in Two Steps
    Publication number: 20140371451
    Abstract: The invention discloses a method for the preparation of tert-butyl 6-chloro-3,5-dioxohexanoate from Meldrum's acid derivative and its use for the preparation of tert-butyl (4R,6S)-(6-hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetate (BHA), Rosuvastatin and Atorvastatin.
    Type: Application
    Filed: August 28, 2014
    Publication date: December 18, 2014
    Inventors: Christian Noti, Guixian Hu, Barry Jackson
  • Preparation of 3,5-dioxo hexanoate ester in two steps
    Patent number: 8859786
    Abstract: The invention discloses a method for the preparation of tert-butyl 6-chloro-3,5-dioxohexanoate from Meldrum's acid derivative and its use for the preparation of tert-butyl(4R,65)-(6-hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetate (BHA), Rosuvastatin and Atorvastatin.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: October 14, 2014
    Assignee: Lonza Ltd
    Inventors: Christian Noti, Guixian Hu, Barry Jackson
  • PREPARATION OF 3,5-DIOXO HEXANOATE ESTER IN TWO STEPS
    Publication number: 20140024842
    Abstract: The invention discloses a method for the preparation of tert-butyl 6-chloro-3,5-dioxohexanoate from Meldrum's acid derivative and its use for the preparation of tert-butyl(4R,65)-(6-hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetate (BHA), Rosuvastatin and Atorvastatin.
    Type: Application
    Filed: March 29, 2012
    Publication date: January 23, 2014
    Applicant: LONZA LTD
    Inventors: Christian Noti, Guixian Hu, Barry Jackson
  • PROCESS FOR THE PREPARATION OF (1S,4R)-2-OXA-3-AZABICYCLO[2,2.1]HEPT-5-ENES
    Publication number: 20120157671
    Abstract: Enantiomerically enriched (1S,4R)-2-oxa-3-azabicyclo[2.2.1]hept-5-ene of formula wherein PG1 is an amino-protective group, are prepared from cyclopentadiene via hetero-Diels-Alder cycloaddition with protected 1-C-nitroso-?-D-ribofuranosyl halides of formula wherein X is a halogen atom selected from fluorine, chlorine, bromine and iodine, PG2 is a hydroxyl-protective group and PG3 is a 1,2-diol-protective group.
    Type: Application
    Filed: August 25, 2010
    Publication date: June 21, 2012
    Inventors: Manuela Franzen, Christian Noti