Patents by Inventor Christian Oliver Kappe

Christian Oliver Kappe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING BTK INHIBITORS
    Publication number: 20240132508
    Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3?-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4?]bipyridinyl-2?-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided.
    Type: Application
    Filed: November 3, 2023
    Publication date: April 25, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Stephan BACHMANN, Lukas CHYTIL, Serena Maria FANTASIA, Alec FETTES, Ursula HOFFMANN, Christian Oliver KAPPE, Rene LEBL, Kurt PUENTENER, Paolo TOSATTI, Jason Douglas WILLIAMS
  • PROCESS FOR THE MANUFACTURE OF TETRAZOLE DERIVATIVES
    Publication number: 20240002355
    Abstract: The invention relates in particular to a process for the preparation of a compound of formula (I) wherein R1 and R2 are as defined in the description and in the claims.
    Type: Application
    Filed: May 22, 2023
    Publication date: January 4, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dainis KALDRE, Christian Oliver KAPPE, Christian Steffen MOESSNER, Peter SAGMEISTER, Joerg Mathias SEDELMEIER, Jason Douglas WILLIAMS
  • PROCESSES FOR PREPARING NOR-OPIOID COMPOUNDS AND OPIOID ANTAGONISTS BY ELECTROCHEMICAL N-DEMETHYLATION
    Publication number: 20230242547
    Abstract: The present disclosure relates to a process for preparing a nor-opioid compound wherein an opioid precursor compound is electrochemically N-demethylated. The present disclosure further relates to a process for preparing an opioid antagonist compound, wherein an opioid precursor compound is electrochemically N-demethylated and the thus obtained nor-opioid compound is alkylated again at its secondary amine functional group.
    Type: Application
    Filed: May 10, 2021
    Publication date: August 3, 2023
    Inventors: Gabriel GLOTZ, David CANTILLO NIEVES, Christian Oliver KAPPE
  • METHOD FOR PREPARATION OF DIFLUOROMETHYLORNITHINE
    Publication number: 20200148627
    Abstract: The invention discloses a method for preparation of protected difluoromethylornithine by a difluoromethylation of dibenzaldimine ornithine ester using CHF3 and LiHMDS (lithium bis(trimethylsilyl)amide), which can be converted to a salt of unprotected difluoromethylornithine by a subsequent deprotection under acidic conditions in the presence of water.
    Type: Application
    Filed: September 24, 2018
    Publication date: May 14, 2020
    Inventors: Bernhard GUTMANN, Michael BERSIER, Paul HANSELMANN, Christian Oliver KAPPE, Manuel KOECKINGER, Christopher HONE
  • N-demethylation of morphinan alkaloids
    Patent number: 10626120
    Abstract: The present disclosure relates to N-demethylation of a compound containing a tertiary N-methylamine, including for example a morphinan alkaloid, in a continuous flow system. In particular, the present disclosure relates to N-demethylation of oxymorphone-3,14-diacetate or 14-hydroxymorphinone-3,14-diacetate using highly active catalytic palladium (0) in a continuous flow system under elevated temperature and pressure condition. The methodology can be utilized towards the synthesis of noroxymorphone via aerobic palladium-catalyzed continuous flow N-demethylation.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: April 21, 2020
    Assignee: Noramco, LLC
    Inventors: Dominique Roberge, Petteri Elsner, Christian Oliver Kappe, Bernhard Gutmann, Ulrich Weigl, Douglas Phillip Cox
  • N-DEMETHYLATION OF MORPHINAN ALKALOIDS
    Publication number: 20190330221
    Abstract: The present disclosure relates to N-demethylation of a compound containing a tertiary N-methylamine, including for example a morphinan alkaloid, in a continuous flow system. In particular, the present disclosure relates to N-demethylation of oxymorphone-3,14-diacetate or 14-hydroxymorphinone-3,14-diacetate using highly active catalytic palladium (0) in a continuous flow system under elevated temperature and pressure condition. The methodology can be utilized towards the synthesis of noroxymorphone via aerobic palladium-catalyzed continuous flow N-demethylation.
    Type: Application
    Filed: April 21, 2017
    Publication date: October 31, 2019
    Inventors: Dominique Roberge, Petteri Elsner, Christian Oliver Kappe, Bernhard Gutmann, Ulrich Weigl, Douglas Phillip Cox