Abstract: The invention relates to anti-CAIX antibodies comprising a heavy chain constant region comprising one or more amino acid substitutions compared to a wild-type IgG, wherein the one or more amino acid substitutions reduce the affinity of the antibody for the neonatal Fc receptor (FcRn), thereby reducing the serum half-life of the modified antibody compared to a wild-type antibody of class IgG. The one or more amino acid modification having the effect of reducing FcRn binding is selected from positions His310, His433, His435, His436, Ile253. Antibodies of the present invention are particularly suited for use in radioimmunotherapy.

Abstract: The invention relates to anti-PSMA antibodies comprising a heavy chain constant region comprising one or more amino acid substitutions compared to a wild-type IgG, wherein the one or more amino acid substitutions reduce the affinity of the antibody for the neonatal Fc receptor (FcRn), thereby reducing the serum half-life of the modified antibody compared to a wild-type antibody of class IgG. The one or more amino acid modification having the effect of reducing FcRn binding is selected from positions His310, His433, His435, His436, Ile253. Antibodies of the present invention are particularly suited for use in radioimmunotherapy.

Abstract: A method of registration of a functional emission image to another image, e.g. a structural/anatomical image, is disclosed in which the emission image is first processed to mask out regions of the background and lungs identified in a corresponding transmission image. Only areas which are not masked out in the emission image are matched to areas in the x-ray image. The x-ray image and masked emission image may then be displayed in superposition.

Abstract: A method of dynamic contrast enhanced magnetic resonance imaging, and of processing the signals from such imaging, in order to improve the characterisation of tissue types being imaged. A calculation of the longitudinal relaxation time T1 is made for each voxel in the image by applying pulse sequences having different flip angles or TRs and fitting the resulting resonance signals to a model of the imaging process. Dynamic, contrast-enhanced imaging is then conducted and by using the T1 values the results may be fitted to a pharmacokinetic model of the uptake of contrast agent in the tissue being imaged. This gives values for physiological parameters relating to the permeability of the tissue and the extravascular extracellular space volume fraction. These, together with the T1 value provide an excellent characterisation of the tissue as malignant or benign.

Abstract: A system for controlling medical data acquisition, such as imaging, comprises a supervisory protocol controller which controls in real time a data acquisition device, such as an imaging apparatus, and an agent administration controller, such as a drug delivery device for delivering contrast agent. The supervisory protocol controller receives data from the acquisition apparatus and controls the acquisition apparatus and the administration controller based on that acquired data. Thus the acquisition protocol can be controlled and changed in response to the actual acquisition circumstances.

Abstract: A method of dynamic medical imaging in which the quality of image registration or motion correction between the frames is assessed by examining the temporal behaviour of a region of interest through the sequence, and in particular how closely the behaviour follows expected behaviour. For a temporal sequence a temporal model of the expected behaviour of the region of interest is available and the quality of fit between the model and the data points from the dynamic imaging sequence can be calculated. In image regions of high patient motion the fit will be poor, whereas if there is no patient motion the fit will be better. The quality of fit can be displayed on the image as an indication of the validity of motion correction, and in areas of poor fit the motion correction can be re-executed using different parameters to try and improve the fit between the behaviour model and the actual data points. The invention is applicable to any contrast-enhanced medical imaging technique.

Abstract: A processing system which comprises a processing apparatus and a processing agent which is administered to a processing subject. The processing agent has a primary behaviour which provides the desired process result in conjunction with the apparatus, but also has a distinctive signature characteristic which is detected by test functionality in the processing system. The behaviour of the processing system can be modified in response to the test result. In an example such as a contrast enhanced medical imaging, the full functionality of the imaging equipment may be available only if a contrast agent having the particular distinctive signature characteristic is used, thus tying use of the apparatus to use of a particular agent.

Abstract: A method of registration of a functional emission image to another image, e.g. a structural/anatomical image, is disclosed in which the emission image is first processed to mask out regions of the background and lungs identified in a corresponding transmission image. Only areas which are not masked out in the emission image are matched to areas in the x-ray image. The x-ray image and masked emission image may then be displayed in superposition.

Abstract: A method of communicating medical information comprising the steps of: obtaining raw image data from at least a portion of the body of a subject; constructing a computer representation of the raw image data; applying image processing to the computer representation; and giving the result of the image processing to a person to whom medical information contained in the image data is to be communicated.