Abstract: A drug delivery device (1; 100; 200) comprising a housing (2; 102; 201, 202), a dose setting mechanism operable to set a dose to be delivered from a variable volume reservoir, and a dose delivery structure (60; 160; 260) activatable to expel a set dose. The dose setting mechanism comprises a dose indicating structure (40; 140; 240) for indicating a size of the set dose. The dose indicating structure (40; 140; 240) is coupled with the dose delivery structure (60; 160; 260) during expelling of the set dose and moved relative to the housing (2; 102; 201, 202) to a zero dose indicating position. The zero dose indicating position is a position which is fixed with respect to the housing (2; 102; 201, 202). The dose setting mechanism further comprises a dose setting structure (20; 120; 220) movable in a dose preparing direction relative to the housing (2; 102; 201, 202) to a dose prepared position to set a dose of a first size.

Abstract: A sensor device is provided, which has an energy storage cell and at least one carrier substrate for at least one detector. The sensor device is characterized in that the at least one carrier substrate has at least one contact section for producing an electrically conductive and mechanical contact to the energy storage cell.

Abstract: The present Invention relates to an injection device capable of emitting a flashing light signal indicating the time elapsed since last ejection and/or the size of the last ejected dosage and/or a return signal indicating the operable state of the device and/or a time out signal indicating when the pen can be removed after ejecting of a dosage. The injection device comprises an electronic control circuit comprising: a sensor unit arranged to detect the occurrence of an ejection of a drug from the injection device; a timer for determining an approximate time elapsed since last ejection; a signal emitting device being able to emit a signal, the signal emitting device being controllable by the electric control circuit, so as to emit a time signal that varies with the time elapsed since last ejection.

Abstract: The present invention pertains to a high drug load tablet comprising as active ingredient Compound I of formula or a pharmaceutically acceptable salt thereof in an amount from about 30% to 80% in weight of the active moiety based on the total weight of the tablet.

Abstract: Embodiments relate to systems and methods including a step of switching between two or more erase operations and/or two or more write operations for erasing of and/or writing to least one memory cell of a nonvolatile memory enabling to select a most suitable erase and/or write operation for a particular erase and/or write operation within the memory.

Abstract: A method is suggested for processing a target memory, the method comprising the steps of (i) checking the target memory subsequent to an erase operation directed to the target memory; and (ii) replacing the target memory with a spare memory in case a defect is detected.

Abstract: A sensor device is provided, which has an energy storage cell and at least one carrier substrate for at least one detector. The sensor device is characterized in that the at least one carrier substrate has at least one contact section for producing an electrically conductive and mechanical contact to the energy storage cell.

Abstract: The present invention relates to a dial-down mechanism for an injection device comprising a torsion spring for assisting injection of a dose of medicament from the injection device, the dial-down mechanism comprising a ratchet arm (21) engaging a ring element (10) and a reset element (30) which acts on a knob located on the periphery of the ratchet arm (21) to move the ratchet arm (21) out of engagement with the ring element (10) in order to allow the set dose to be reduced.

Abstract: Embodiments of the present invention provide high durability joints between ceramic articles, particularly between beta-silicon carbide (?-SiC) articles, and methods of making and using the same. In one embodiment, a joint between first and second articles each comprising a ceramic polymorph comprises a matrix comprising the ceramic polymorph and extending between the first and second articles; a plurality of inclusions comprising the ceramic polymorph and being distributed throughout the matrix; and a sealing layer comprising the ceramic polymorph and being respectively disposed on the first and second articles and the matrix.

Abstract: An injection device (1) with an End-of-Content mechanism. The End-of-Content mechanism comprises a track (91) and a track follower each coupled directly or indirectly to the housing and the dose setting member (20). When setting a dose, the housing and the dose setting member is rotated relatively to each other thereby also rotating the track-follower in the track a distance corresponding to the size of the set dose. This relative rotation is summarized and stored in the position of the track follower in the track. The housing containing the mechanism is preferably equipped with a transparent (71) area through which a user can inspect the position of the track follower in the track and thereby get a visible warning when the drug reservoir in the injection device is about to be emptied.

Abstract: The invention relates to an injection device (1, 100) configured to perform automatic priming upon removal of a protective cap (15, 115) from a cap receiving portion (9, 109) of a housing (2, 102). When mounted on the injection device (1, 100) the cap (15, 115) defines a first position for a drive member (10, 110) relative to the housing (2, 102), which drive member (10, 110) is capable of causing a piston rod (7, 107) to advance a piston (8, 108) in a reservoir (4, 104). Means (13, 120) are provided defining a second position for the drive member (10, 110) relative to the housing (2, 102). During removal of the cap (15, 115) from the cap receiving portion (9, 109) the drive member (10, 110) moves from the first position to the second position under the influence of a spring (11, 111), thereby causing the piston rod (7, 107) to pressurize the reservoir (4, 104).

Abstract: Educational and instructive kits for surfboard construction are provided. In accordance with various embodiments of the present teachings, kits for making wooden and fiberglass scale-model surfboards can include blanks, templates, instructions, and/or other materials. A kit in accordance with the present teachings provides an educational tool for developing the skills for, and an understanding of, surfboard construction. As well, a kit of the present teachings can be employed in scale-model prototyping of surfboard designs.

Abstract: The invention relates to a medical drug delivery apparatus which comprises a cartridge (1) being closed at one end by a membrane (12) and at the opposite end by a movable piston (15). A piston rod foot (1) is provided for transferring the pressure from the piston rod (20) of the drug delivery apparatus and onto the piston (15). The piston rod foot (1) comprises a center part (2) abutting the piston rod (20) and an outer part (3) which center part (2) and outer part (3) are releasable coupled together such that the two (2, 3) can be released when a force above a certain threshold limit is applied to the outer part (3).

Abstract: The present invention pertains to a high drug load tablet comprising as active ingredient Compound I of formula or a pharmaceutically acceptable salt thereof in an amount from about 30% to 80% in weight of the active moiety based on the total weight of the tablet.

Abstract: The invention relates to a medical drug delivery apparatus which comprises a cartridge (1) being closed at one end by a membrane (12) and at the opposite end by a movable piston (15). A piston rod foot (1) is provided for transferring the pressure from the piston rod (20) of the drug delivery apparatus and onto the piston (15). The piston rod foot (1) comprises a centre part (2) abutting the piston rod (20) and an outer part (3) which centre part (2) and outer part (3) are coupled together such that the two (2, 3) can be moved relative to one another, yet remain coupled to each other, when a force above a certain threshold limit is applied to the outer part (3).

Abstract: The invention relates to a biaxially oriented microporous film composed of at least two coextruded layers encompassing an external shut-off layer and another layer, wherein both layers contain a mixture of propylene homopolymer and propylene block copolymer and ?-nucleation agent. The propylene block copolymer I of the other layer has a melting point exceeding 140° C. and the propylene block copolymer II of the external shut-off layer has a melting range starting at a temperature ranging from 50 to 120° C. The melting point of the propylene block copolymer I is greater than the melting point of the propylene block copolymer II. The film can be used as a separator in a primary or secondary battery.

Abstract: The invention relates to methods and systems for reading a memory cell and in particular, an STT MRAM. In accordance with one aspect of the invention, a method for reading a memory cell includes combining a cell current from a memory cell with a reference current from a reference source to create an average current, enabling the average current to flow through a first mirror transistor in a sense path and a second mirror transistor in a reference path, storing the current mismatch on a capacitor coupled to the gates of the first mirror transistor and the second mirror transistor, disconnecting the memory cell from the reference path and disconnecting the reference source from the sense path, enabling the cell current only to flow through the sense path, and determining the output level of the memory cell.

Abstract: An injection device (1) for injecting apportioned doses of liquid drug. The injection device (1) includes a dose setting structure, an injection structure, a removable cap (15) and a cap receiving part (9) adapted to abut or engage with the cap (15) when the cap (15) is mounted on the injection device (1). The dose setting structure is operatively coupled to the cap receiving part (9) in such a manner that mounting and/or dismounting of the cap (15) on/from the injection device (1) causes the dose setting structure to set a dose. Thereby a correct dose of drug is automatically set during a cap on/cap off cycle. Since such a cycle is normally performed between subsequent injections, the number of steps required to be performed by the user is reduced.

Abstract: The present invention pertains to a high drug load tablet comprising an active ingredient Compound I of formula or a pharmaceutically acceptable salt thereof in an amount from about 30% to 80% in weight of the active moiety based on the total weight of the tablet.