Abstract: The present invention relates to diagnostic test and technology.

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.

Abstract: A system, template, and method of managing virtual control units in an industrial automation facility are provided. The industrial automation facility includes machines. The method includes generating templates including deployment criteria for the virtual control units. Each of the virtual control units is capable of controlling at least one of the machines. The virtual control units are mapped to one or more compute nodes based on the deployment criteria. The virtual control units are instantiated on the mapped compute nodes when the controlled machines are in operation. The method includes validating that the instantiation of the virtual control units is in accordance with the templates using an attestation that confirms determined deployment parameters after deployment of the virtual control units. The machines perform the industrial process, according to control commands received from at least one of the virtual control units, when the virtual control units are validly instantiated.

Abstract: The invention relates to a protective helmet with an outer shell (1) for distributing impact forces, an interior layer (2) accommodated by the outer shell (1) for attenuating impact forces, and a slot (3) for accommodating an electrical device (4), wherein the outer shell (1) has a chin shell area (6) to cover a chin portion of a protective helmet wearer, wherein the outer shell (1) forms a viewing port (8) for the protective helmet wearer to look through. The protective helmet is characterized in that the slot (3) is arranged on the chin shell area (6) in such a way that the accommodated electrical device (4) is arranged between the chin shell area (6) and the interior layer (2), wherein the protective helmet has an interior cover (10) for essentially completely covering the accommodated electrical device (4) in the direction of the viewing port (8).

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: W—X—Y—Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: Methods and systems are configured to store user data and control access to the user data, wherein the data is stored remotely from the user (such as external to a user's computing device) and the user's data is maintained anonymously. Content is stored in association with a user identifier and access by third parties is controlled by linked third party identifiers.

Abstract: This patent document relates to systems, structures, devices, and fabrication processes for ceramic matrix composites suitable for use in a nuclear reactor environment and other applications requiring materials that can withstand high temperatures and/or highly corrosive environments. In one exemplary aspect, a method of joining and sealing ceramic structures is disclosed. The method comprises forming a joint of a ceramic structure and an end plug using a sealing material, wherein the end plug has a hole that goes through a top surface and a bottom surface of the end plug; filling the ceramic structure with a desired gas composition through the hole; heating a material into a molten form using a heat source; and directing the material into the hole, wherein the material solidifies to seal the end plug.

Abstract: Various embodiments of the teachings herein include an attestation component configured to attest a cloud-based execution environment. The cloud-based execution environment comprises at least one application instance and a project plan assigned to the at least one application instance. The attestation component may include: a determination component configured to determine at least one piece of trustworthiness information indicating a trustworthiness of the cloud-based execution environment and of the at least one application instance; and a linking component configured to establish a link between the trustworthiness information and the project plan.

Abstract: Method and system for providing control applications for industrial automation devices, wherein in order to provide control applications, which are each provided via flow control components, the flow control components are each classified, based on configuration information, or referenced memory maps, with respect to access to at least one socket of a flow control environment when their execution is started, where a classification for each of the flow control components is used to create or reference a permissions profile for socket access, an individual token, associated with a permissions profile, for the socket access is created for each flow control component and transferred to the respective flow control component, and where the tokens and/or the permissions profiles each have an application-specific resource access guideline combined with therewith which is transmitted to a control component for application, which control component opens the respective socket.

Abstract: A mold sensor is configured with an enclosed chamber in which a nutrient-treated substrate is positioned. The mold sensor includes an optical sensor that is configured to measure optical properties in the enclosed chamber. A controller operates the optical sensor and is programmed to detect a presence of mold growing in the chamber based on the optical properties measured by the optical sensor.

Abstract: Disclosed herein are nonwoven webs comprising a nonwoven substrate and a binder comprising a polysaccharide. In one embodiment, the polysaccharide can comprise poly alpha-1,3-glucan, a poly alpha-1,3-glucan ether compound as disclosed herein, a poly alpha-1,3-glucan ester compound as disclosed herein, a graft copolymer comprising a backbone comprising dextran and poly alpha-1,3-glucan side chains, a crosslinked graft copolymer comprising a backbone comprising dextran and poly alpha-1,3-glucan chains, or a mixture thereof. Also disclosed are articles comprising the nonwoven webs, and methods of making the nonwoven webs.

Abstract: Disclosed herein are polysaccharide-elastomer masterbatch compositions and processes for preparing the masterbatch compositions. One method comprises a step of a) mixing i) an aqueous polysaccharide dispersion, or ii) a basic aqueous polysaccharide solution, with a rubber latex solution containing a rubber component to form a mixture. The method further comprises the steps of: b) coagulating the mixture obtained in step a) to produce a coagulated mass; and c) drying the coagulated mass obtained in step b). The masterbatch compositions are useful in preparing rubber-containing articles.

Abstract: Compositions are disclosed herein comprising a rubber component and a polysaccharide, wherein the polysaccharide comprises i) poly alpha-1,3-glucan; ii) poly alpha-1,3-1,6-glucan; iii) water insoluble alpha-(1,3-glucan) polymer having 90% or greater ?-1,3-glycosidic linkages, less than 1% by weight of alpha-1,3,6-glycosidic branch points, and a number average degree of polymerization in the range of from 55 to 10,000; iv) dextran; v) a composition comprising poly alpha-1,3-glucan ester compounds as disclosed herein; or vi) water-insoluble cellulose having a weight-average degree of polymerization (DPw) of about 10 to about 1000 and a cellulose II crystal structure. The compositions can be used in articles such as a tire, a belt, a seal, footwear, a coating, a film, or an adhesive.

Abstract: A method for verifying an execution environment provided by a configurable hardware module, where the execution environment is used for execution of at least one hardware-application, includes receiving a hardware-application 16. The hardware-application includes configuration data describing an instantiation as a hardware-application component on the configurable hardware module. A received hardware-application is instantiated as the hardware-application component in the execution environment. The execution environment of the configurable hardware module that executes the hardware-application component in the respective execution environment is analyzed by an instantiated hardware-application component. The hardware application component communicates with a characterizing unit providing characterizing parameters for the execution environment of the configurable hardware module.

Abstract: An electronic device stores a plurality of vector representations for respective media content items in a vector space, where each vector represents a media content item. The electronic device receives a first set of input parameters representing a previous session of a user of the media-providing service where the previous session included two or more of the respective media content items. The electronic device then receives a second set of input parameters representing a current context of the user and provides the first set of input parameters and the second set of input parameters to a neural network to generate a prediction vector for a current session. The prediction vector is embedded in the vector space.

Abstract: Methods, systems and computer program products are provided for query understanding. A non-focused query quantifier generates non-focused query features that quantify a non-focused query and a non-focused query predictor generates a prediction associated with the non-focused query based on the non-focused query features.

Abstract: The invention relates to a process for identifying patients affected by an autoimmune neurological disease, comprising a step of detection of at least one type of anti-Argonaute autoantibodies (AGO-Abs) in a biological sample of an individual susceptible to be affected by said disease, wherein positive detection of said at least one type of AGO-Abs means that said individual is affected by said autoimmune neurological disease.

Abstract: In one embodiment, a temperature sensor system includes a sensor assembly with a temperature sensing portion configured to generate a first signal based upon a temperature of body proximate a surface portion of the temperature sensing portion, and a thermoelectric generator portion configured to receive heat flow from the body through the temperature sensing portion and to generate a second signal based upon the heat flow. A control unit is operably connected to the sensor assembly and a memory and configured to execute program instructions stored in the memory to calculate and output a corrected temperature based upon the first signal, the second signal, and at least one correction factor stored in the memory. The at least one correcting factor is determined based upon at least one of a thermal conductivity of the sensor assembly, a size of the sensor assembly, and an aspect ratio of the sensor assembly.

Abstract: The following relates to a hardware security module for usage with manufacturing devices and a method for operating the same is provided. The security module includes: a secure element, which is adapted to detect an operating mode of the hardware security module; a first interface which is adapted to receive commands for controlling the hardware security module; a central processing unit for processing application program code in a secure environment; a second interface which is adapted for receiving configuration data, wherein the second interface is activated and deactivated in dependence of the detected operating mode.

Abstract: A system and method for operating a personal grooming/household appliance, including: providing a personal grooming/household appliance including at least one physical sensor taken from a group consisting of: an orientation sensor, an acceleration sensor, an inertial sensor, a global positioning sensor, a pressure sensor, and a load sensor, audio sensor, humidity sensor, and a temperature sensor; providing a camera associated with the personal grooming/household appliance; classifying data received from the physical sensor and from the camera using at least one trained machine learning classifier to generate an augmented classification; and providing user feedback information based upon the augmented classification or modifying operation of the grooming/household appliance based upon the augmented classification.