Abstract: The present invention relates to a method for detecting and/or tracking and/or characterizing the formation of a biofilm. The present invention also relates to a device for detecting and/or characterizing the formation of a biofilm suitable for implementing the method. The present invention can be used in particular in the analytical fields, in biological and enzymological research, in the pharmaceutical field and/or in the medical field.

Abstract: The present invention relates to a method for determining the biofilm-forming capacity of microorganisms. The present invention also relates to a method for classifying microorganisms according to the biofilm-forming capacity thereof. In particular, the present invention is useful in the fields of analysis, biological and enzymological research, pharmaceuticals, diagnostics and/or medicine. The present invention is also useful in the clinical, environmental and food-processing fields.

Abstract: A pharmaceutical composition comprising cloxacillin for use as a medicament for the prevention of bacterial biofilm formation. Use of cloxacillin for the prevention and/or inhibition of bacterial biofilm formation on a surface.

Abstract: The present invention relates to a method for determining the biofilm-forming capacity of microorganisms. The present invention also relates to a method for classifying microorganisms according to the biofilm-forming capacity thereof. In particular, the present invention is useful in the fields of analysis, biological and enzymological research, pharmaceuticals, diagnostics and/or medicine. The present invention is also useful in the clinical, environmental and food-processing fields.

Abstract: A method of amplifying all of the DNA fragments of a sample, including fragments that are small or damaged, comprises an initial step of generating free 3′-OH end with P1 nuclease. The method also provides for extraction of the DNA fragments from a sample and reduction of their size to between 100 and 300 base pairs. A poly(dX) oligonucleotide is added to the 3′ ends of the DNA fragments using a terminal transferase, and the DNA is denatured and hybridized to a poly(dY) primer complementary to the poly(dX) ends. Finally, the DNA is polymerized with DNA polymerase. The resulting DNA can be amplified by denaturing and slowly renaturing the complementary strands.

Abstract: The invention concerns a method for detecting impairment of DNA comprising contacting a sample DNA with a composition comprising at least one recognition protein selected from the group consisting of proteins belonging to the nucleotide excision repair system, proteins belonging to the base excision repair system, and proteins belonging to the system for detecting DNA breaks and detecting a complex formed between the recognition protein and DNA to thereby detect impairment of the DNA sequence.

Abstract: A method for the qualitative and quantitative detection of damages to DNA, characterised in that it includes the steps of binding the target DNA to a sensitised substrate, subjecting the DNA to the action of a test composition comprising at least one damage-generating product, subjecting the DNA to the action of a composition containing at least one cell extract active in repairing the DNA and containing markers, and detecting directly or indirectly the markers optionally incorporated into the DNA, if the repair has been effective, wherein a washing step is included between the steps and the binding and damaging steps can be reversed. The invention also provides a method for capturing the DNA directly from the cells with a lysis solution and a method for determining the repair modulation effect of some molecules. The method is suitable for detecting DNA damage and the repair inhibition modulating activity of one or more molecules.