Patents by Inventor Christian Quirin

Christian Quirin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for biocatalytic whole cell reduction of dehydrocholic acid compounds, and 7-?-hydroxysteroid dehydrogenase mutants
    Patent number: 10544441
    Abstract: The invention relates to novel biocatalytic processes comprising the whole cell reduction of dehydrocholic acid (DHCA) compounds, novel 7?-hydroxy steroid dehydrogenase mutants, the sequences coding for these enzyme mutants, methods for producing the enzyme mutants and use thereof in enzymatic conversions of cholic acid compounds, and in particular in the production of ursodesoxycholic acid (UDCA); also a subject of the invention are novel methods for the synthesis of UDCA using the enzyme mutants; and in particular a further improved method for producing UDCA using recombinant whole cell biocatalysts.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: January 28, 2020
    Assignee: PharmaZell GmbH
    Inventors: Dirk Weuster-Botz, Boqiao Sun, Christian Quirin
  • Method for Biocatalytic Whole Cell Reduction of Dehydrocholic Acid Compounds, and 7-Beta-Hydroxysteroid Dehydrogenase Mutants
    Publication number: 20170191104
    Abstract: The invention relates to novel biocatalytic processes comprising the whole cell reduction of dehydrocholic acid (DHCA) compounds, novel 7?-hydroxy steroid dehydrogenase mutants, the sequences coding for these enzyme mutants, methods for producing the enzyme mutants and use thereof in enzymatic conversions of cholic acid compounds, and in particular in the production of ursodesoxycholic acid (UDCA); also a subject of the invention are novel methods for the synthesis of UDCA using the enzyme mutants; and in particular a further improved method for producing UDCA using recombinant whole cell biocatalysts.
    Type: Application
    Filed: June 24, 2015
    Publication date: July 6, 2017
    Inventors: Dirk Weuster-Botz, Boqiao Sun, Christian Quirin