Abstract: The invention relates to a device for generating temporally spaced light pulses. Said device comprises a first light source which emits a first train of light pulses, a second light source which emits a second train of light pulses, and a phase-locked loop which regulates the relative phase of the light-pulse trains towards a target value. When the two light-pulse trains each pass through an optical transmission path to an application site that is spatially remote from the light sources, fluctuating phase differences in the light-pulse trains at the application site occur due to external influences along the transmission paths. The object of the invention is to provide an improved device for generating temporally spaced light pulses. In particular, the above-mentioned fluctuating phase differences are intended to be prevented.

Abstract: The invention relates to an illumination device, in particular for a confocal microscope. The object of the invention is to provide an illumination device which operates with a plurality of current-modulated semiconductor-based light sources, in which the light emission is as free as possible from distortions due to dynamic delays of the light emission in the output beam.

Abstract: A motor vehicle disk brake has a sleeve which is manufactured from elastomer for the purpose of sealing a gap between the bolt and the brake holder. The sleeve has ribs lying against the bolt. The ribs are arranged parallel to the axis of the bolt and are odd in number. A release operation of the motor vehicle disk brake is assisted by the sleeve.

Abstract: The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.

Abstract: The invention relates to an illumination device, in particular for a confocal microscope. The object of the invention is to provide an illumination device which operates with a plurality of current-modulated semiconductor-based light sources, in which the light emission is as free as possible from distortions due to dynamic delays of the light emission in the output beam.

Abstract: The invention relates to a device for generating temporally spaced light pulses. Said device comprises a first light source which emits a first train of light pulses, a second light source which emits a second train of light pulses, and a phase-locked loop which regulates the relative phase of the light-pulse trains towards a target value. When the two light-pulse trains each pass through an optical transmission path to an application site that is spatially remote from the light sources, fluctuating phase differences in the light-pulse trains at the application site occur due to external influences along the transmission paths. The object of the invention is to provide an improved device for generating temporally spaced light pulses. In particular, the above-mentioned fluctuating phase differences are intended to be prevented.

Abstract: The invention relates to an apparatus for generating temporally spaced apart light pulses, comprising a first laser (11) which generates a first sequence (I) of light pulses at a first repetition rate, a second laser (12) which generates a second sequence (II) of light pulses at a second repetition rate, and at least one actuating member which influences the first repetition rate and/or the second repetition rate. It is an object of the invention to provide an apparatus for generating temporally spaced apart light pulses which is improved in relation to the prior art.

Abstract: The invention relates to an apparatus for generating temporally spaced apart light pulses, comprising a first laser (11) which generates a first sequence (I) of light pulses at a first repetition rate, a second laser (12) which generates a second sequence (II) of light pulses at a second repetition rate, and at least one actuating member which influences the first repetition rate and/or the second repetition rate. It is an object of the invention to provide an apparatus for generating temporally spaced apart light pulses which is improved in relation to the prior art.

Abstract: The invention relates to a method for the amination of at least one keto group in a multicyclic ring system comprising at least one keto group into an amino group, using at least one enzyme E having transaminase activity.

Abstract: The invention relates to a method for the amination of at least one keto group in a multicyclic ring system comprising at least one keto group into an amino group, using at least one enzyme E having transaminase activity.

Abstract: A device for generating light pulses that are separated in terms of time has a light source that emits a sequence of light pulses. A regulation signal is formed within a regulation circuit from a cycle signal and the light pulse sequence of the light sources via a phase detector. The regulation circuit includes a regulator that generates a setting signal that influences the repeat frequency of the light pulse sequence of the light source.

Abstract: A device for generating light pulses that are separated in terms of time has a light source that emits a sequence of light pulses. A regulation signal is formed within a regulation circuit from a cycle signal and the light pulse sequence of the light sources via a phase detector. The regulation circuit includes a regulator that generates a setting signal that influences the repeat frequency of the light pulse sequence of the light source.

Abstract: The present invention relates to peptides which interact with IAPs. IAPs are highly expressed in tumor cells which fail to undergo apoptosis. By binding to IAPs, the peptides of the present invention release tumor cells from the apoptosis block and thus provide a new tool for effective cancer therapy.

Abstract: The present invention relates to peptides which interact with IAPs. IAPs are highly expressed in tumor cells which fail to undergo apoptosis. By binding to IAPs, the peptides of the present invention release tumor cells from the apoptosis block and thus provide a new tool for effective cancer therapy.