Abstract: A reprocessing apparatus, in particular a cleaning and/or preserving apparatus, for tools, tool holders and/or tool units is proposed, with at least one reprocessing unit, in particular for a reprocessing of used and/or contaminated tools, tool holders and/or tool units, with at least one holding unit for an exchangeable holding of the tools, tool holders and/or tool units, and with at least one handling unit which is configured, for an execution of a cleaning process on the tools, tool holders and/or tool units, to bring the holding unit and at least one cleaning region of the reprocessing unit together in an at least semiautomated manner, and after execution of the cleaning process, to remove the holding unit and the cleaning region of the reprocessing unit from each other in an at least semiautomated manner, and/or after execution of the cleaning process, to bring the holding unit and at least one further cleaning region of the reprocessing unit together for an execution of a further cleaning process.

Abstract: Isotopically-labelled glycans and their synthesis and use as internal standards in the analysis by mass spectrometry of glycan mixtures is described. The methods of synthesis described herein may be used conveniently to prepare libraries of heavy glycans for use in the qualitative and quantitative identification of glycans in natural samples.

Abstract: The invention proceeds from a product-stream-transfer apparatus (10a) for transferring at least a first product sub-stream (12a) and a further product sub-stream (14a) into a main product stream (16a) or for separating a main product stream into at least a first product sub-stream and a further product sub-stream along a product-stream-transfer route (18a), having a first side route (20a) with a multiplicity of transporting elements (22a) for transporting products (24a) of the first product sub-stream (12a), having at least a further side route (26a) with a multiplicity of transporting elements (22a) for transporting products (24a) of the further product sub-stream (14a), and having a main route (28a), which is adjacent to the product-stream-transfer route (18a) and is intended for transporting the products (24a) of the main product stream (16a).

Abstract: The invention proceeds from a product-stream-transfer apparatus (10a) for transferring at least a first product sub-stream (12a) and a further product sub-stream (14a) into a main product stream (16a) or for separating a main product stream into at least a first product sub-stream and a further product sub-stream along a product-stream-transfer route (18a), having a first side route (20a) with a multiplicity of transporting elements (22a) for transporting products (24a) of the first product sub-stream (12a), having at least a further side route (26a) with a multiplicity of transporting elements (22a) for transporting products (24a) of the further product sub-stream (14a), and having a main route (28a), which is adjacent to the product-stream-transfer route (18a) and is intended for transporting the products (24a) of the main product stream (16a).

Abstract: The present invention provides microarrays that can be analysed by more than one technique using a non-covalent ligand attachment strategy to solid supports such as indium tin oxide (ITO) covered transparent glass slides. This provides, inter alia, glycan arrays on a micrometer scale which allow multimodal readout by MALDI-Tof-MS, fluorescence and optical microscopy. Glycans functionalized with a C5-aminolinker were attached in situ on a picomolar scale to a hydrophobic tag bound to this surface, thus avoiding the wasteful off-chip ligand tagging of other approaches. Glycan arrays prepared using this methodology were analysed both with a fluorescence scanner and by on-chip MALDI-mass spectrometry in a series of glycomics experiments specifically requiring a multimodal readout.

Abstract: The invention relates to a method for identifying in a sample molecules with the capacity to bind to the different members of a molecule library, wherein the molecules which are in the sample are fractionated based on a physicochemical property of the sample and subsequently transferred from the support in which said molecules have been separated to a second support in which the different members of the molecule library are grouped into microarrays such that they uniformly coat the surface of the support. This technique is especially interesting for the identification in a sample of glycoproteins with affinity for a lectin library as well as for the identification of compounds capable of modulating the glycosylation of proteins and for the rapid characterization of alterations in the glycosylation pattern of a sample of proteins, which can be useful in the diagnosis of diseases in which there are alterations in cell glycosylation.

Abstract: Isotopically-labelled glycans and their synthesis and use as internal standards in the analysis by mass spectrometry of glycan mixtures is described. The methods of synthesis described herein may be used conveniently to prepare libraries of heavy glycans for use in the qualitative and quantitative identification of glycans in natural samples.

Abstract: The present invention provides microarrays that can be analysed by more than one technique using a non-covalent ligand attachment strategy to solid supports such as indium tin oxide (ITO) covered transparent glass slides. This provides, inter alia, glycan arrays on a micrometer scale which allow multimodal readout by MALDI-Tof-MS, fluorescence and optical microscopy. Glycans functionalized with a C5-aminolinker were attached in situ on a picomolar scale to a hydrophobic tag bound to this surface, thus avoiding the wasteful off-chip ligand tagging of other approaches. Glycan arrays prepared using this methodology were analysed both with a fluorescence scanner and by on-chip MALDI-mass spectrometry in a series of glycomics experiments specifically requiring a multimodal readout.

Abstract: The invention relates to a method for identifying in a sample molecules with the capacity to bind to the different members of a molecule library, wherein the molecules which are in the sample are fractionated based on a physicochemical property of the sample and subsequently transferred from the support in which said molecules have been separated to a second support in which the different members of the molecule library are grouped into microarrays such that they uniformly coat the surface of the support. This technique is especially interesting for the identification in a sample of glycoproteins with affinity for a lectin library as well as for the identification of compounds capable of modulating the glycosylation of proteins and for the rapid characterization of alterations in the glycosylation pattern of a sample of proteins, which can be useful in the diagnosis of diseases in which there are alterations in cell glycosylation.