Abstract: A sensor element (1) has at least one measurement element (2) with piezoelectric and pyroelectric properties, and measurement electrodes (3). A measurement variable and a disturbance variable act simultaneously upon the at least one measurement element (2) and the measurement signal derived from the measurement electrodes (3) includes an interference signal. The sensor element (1) has at least one compensation element (4, 4?) upon which only the disturbance variable acts, so that a correction signal used to compensate for the interference signal in the measurement signal can be derived from the compensation element (4, 4?).

Abstract: A process for connecting at least two workpieces forming a workpiece arrangement, by means of a joining element having at least one radial recess, the joining element being driven axially into the workpiece arrangement while the workpiece arrangement is supported in the axial direction by a hollow die, so that at least one workpiece trimming is forced into the die. A deformation force is exerted on at least one of the workpieces to press material of a workpiece into the radial recess, thereby to set up a positive locking connection between the joining element and a workpiece. The die has a holding structure to hold a workpiece trimming securely in place, so that the workpiece trimming remains in the die when the die and the workpiece arrangement are separated from one another.

Abstract: The invention relates to a method for detecting an infection of a mammal with an acid-resistant microorganism, wherein (a) a stool sample of a mammal is incubated with at least two different monoclonal antibodies, fragments or derivatives thereof or aptamers under conditions allowing a complex formation of antigens of the acid-resistant microorganism with antibodies, fragments or derivatives thereof or the aptamers, and wherein (aa) the first monoclonal antibody or the fragment or the derivative thereof or the first aptamer specifically binds an epitope of the first antigen, which shows at least with some mammals a structure after the intestinal passage that corresponds to the native structure or the structure which a mammal produces antibodies against after being infected or immunised with the acid-resistant microorganism or an extract or lysate thereof or a protein therefrom or a fragment thereof or a synthetic peptide; (ab) the second monoclonal antibody or the fragment or the derivative thereof or the sec

Abstract: The invention relates to a method for detecting an infection of a mammal with an acid-resistant microorganism comprising the following steps: (a) provision of an immunochromatographic test with a sample application area for the application of a stool sample of the mammal with an antigen and application of the stool sample, (b) incubation of the stool sample using (i) a first receptor under conditions permitting a complex formation of the antigen from the acid resistant microorganism with the receptor; or (ii) at least two different first receptors under conditions permitting a complex formation of the antigen from the acid-resistant microorganism with the at least two first receptors and wherein the first receptor according to (i) or the first receptors according to (ii) specifically bind(s) an antigen which shows, at least with some mammals, a structure after passage through the intestine that corresponds to the native structure or the structure against which a mammal produces antibodies against after being

Abstract: The invention relates to a method for detecting an infection of a mammal with an acid-resistant microorganism, wherein (a) a stool sample of a mammal is incubated with at least two different monoclonal antibodies, fragments or derivatives thereof or aptamers under conditions allowing a complex formation of antigens of the acid-resistant microorganism with antibodies, fragments or derivatives thereof or the aptamers, and wherein (aa) the first monoclonal antibody or the fragment or the derivative thereof or the first aptamer specifically binds an epitope of the first antigen, which shows at least with some mammals a structure after the intestinal passage that corresponds to the native structure or the structure which a mammal produces antibodies against after being infected or immunised with the acid-resistant microorganism or an extract or lysate thereof or a protein therefrom or a fragment thereof or a synthetic peptide; (ab) the second monoclonal antibody or the fragment or the derivative thereof or the sec

Abstract: Described are novel antibodies specifically recognizing conformation dependent epitopes of HCV glycoprotein E2 and that are capable aof neutralizing the binding of E2 protein onto susceptible cells. Furthermore, antigens and epitopes recognized by the above-described antibodies as well as polynucleotides encoding said antibodies are provided. Also provided are to vectors comprising said polynucleotides as well as host cells transformed therewith and their use in the production of said antibodies. In addition, pharmaceutical and diagnostic compositions are provided comprising any of the aforedescribed antibodies, antigens, epitopes, polynucleotides, vectors or cells. Further described is the use of the aforementioned antibodies, antigens, polynucleotides and vectors in adoptive immunotherapy, preferably for the treatment or prevention of HCV infection during liver transplantation.

Abstract: The invention relates to a method for determining the non-volatile component of aerosol particles in a gas sample, especially in the exhaust gas of internal combustion engines, where the aerosol particles are deposited on an oscillating sensor (2) of at least one crystal microbalance (3), and the change in at least one oscillation parameter of the oscillating sensor is employed as measurement variable. According to the invention the oscillating sensor (2) of at least one crystal microbalance (3) is maintained at a temperature of more than 200° C. during deposition of the aerosol particles, and preferably between 250° C. and 350° C.

Abstract: Described are novel antibodies specifically recognizing conformation dependent epitopes of HCV glycoprotein E2 and that are capable aof neutralizing the binding of E2 protein onto susceptible cells. Furthermore, antigens and epitopes recognized by the above-described antibodies as well as polynucleotides encoding said antibodies are provided. Also provided are to vectors comprising said polynucleotides as well as host cells transformed therewith and their use in the production of said antibodies. In addition, pharmaceutical and diagnostic compositions are provided comprising any of the aforedescribed antibodies, antigens, epitopes, polynucleotides, vectors or cells. Further described is the use of the aforementioned antibodies, antigens, polynucleotides and vectors in adoptive immunotherapy, preferably for the treatment or prevention of HCV infection during liver transplantation.

Abstract: The present invention relates to a nucleic acid molecule comprising a nucleic acid sequence encoding at least one complementary determining region (CDR) of a variable region of an antibody, said antibody specifically interacting with the extracellular domain of the human zeta-chain, said antibody being obtainable by immunizing a rat with Jurkat cells and subsequently with a conjugate comprising a carrier molecule and a peptide comprising the 11 N-terminal amino acids of a the rat zeta-chain. Preferably, the (poly)peptide encoded by the nucleic acid molecule of the invention is a monospecific or bispecific antibody. The invention also relates to pharmaceutical compositions comprising i. a. the nucleic acid molecule or antibody of the invention as well as to kits comprising the aforementioned compounds. Finally, the invention relates to a method for the determination of zeta-chain or eta-chain expression on NK-cells, T-cells or precursors thereof employing the antibody of the invention.

Abstract: The present invention relates to a new solution for the preparation of stool samples for diagnostic tests. The solution allows samples to be prepared simply before use in an immunological detection process and also provides a high level of sensitivity, specificity and reproducibility of the tests. The solution must contain at least one buffer substance, one detergent and one blocking reagent. The Invention also relates to a process for the analysis of a stool sample for diagnostic purposes using the solution according to the invention.

Abstract: A process to determine aerosol particles in gaseous samples, specifically in the exhaust of diesel motors, includes the at least indirect deposit of aerosol particles on a piezoelectric oscillating crystal and the determination of the oscillation parameters of the piezoelectrically stimulated oscillation of the crystal. In order to assure the required reproducibility reliably and independently of the type of aerosol particles, and thus to achieve a high quality of measurements, the piezoelectric crystal is charged to oscillation during less than half the period of deposit of aerosol particles.

Abstract: The invention relates to a method for detecting an infection of a mammal with an acid-resistant microorganism, wherein (a) a stool sample of a mammal is incubated with at least two different monoclonal antibodies, fragments or derivatives thereof or aptamers under conditions allowing a complex formation of antigens of the acid-resistant microorganism with antibodies, fragments or derivatives thereof or the aptamers, and wherein (aa) the first monoclonal antibody or the fragment or the derivative thereof or the first aptamer specifically binds an epitope of the first antigen, which shows at least with some mammals a structure after the intestinal passage that corresponds to the native structure or the structure which a mammal produces antibodies against after being infected or immunised with the acid-resistant microorganism or an extract or lysate thereof or a protein therefrom or a fragment thereof or a synthetic peptide; (ab) the second monoclonal antibody or the fragment or the derivative thereof or the sec

Abstract: The invention relates to a method for determining the non-volatile component of aerosol particles in a gas sample, especially in the exhaust gas of internal combustion engines, where the aerosol particles are deposited on an oscillating sensor (2) of at least one crystal microbalance (3), and the change in at least one oscillation parameter of the oscillating sensor is employed as measurement variable. According to the invention the oscillating sensor (2) of at least one crystal microbalance (3) is maintained at a temperature of more than 200° C. during deposition of the aerosol particles, and preferably between 250° C. and 350° C.

Abstract: A separating device for connection to a rotating magazine. The separating device transports rivets (3) via a conveyor duct (6) formed by three limiting faces. The first limiting face is a base plate (5), the second limiting face is a right-hand guide segment (1) and the third limiting face is a left-hand guide segment (2). At least one of the guide segments is designed and arranged to be excited and oscillate to avoid jamming of rivets (3) in the conveyor duct (6).

Abstract: An arrangement is described for the quantitative and qualitative analysis of particles in gases, especially of particles in the exhaust gas of internal combustion engines, comprising a vibrating system with at least one vibration sensor, preferably a piezoelectric resonator, which is provided with at least one collecting surface for the particles to be analyzed, a circuit for the determination of characteristic vibration parameters as well as guide and transport arrangements for the gas to be analyzed. In order to obtain as large as possible a measuring range with a linear characteristic line and therewith a great sensitivity and dynamics with respect to the mass load in the entire measuring range, there is provided a vibration sensor stationary relative to the measuring chamber, and at least one active deflecting device for the gas or the particles contained in the gas.

Abstract: A process to determine aerosol particles in gaseous samples, specifically in the exhaust of diesel motors, includes the at least indirect deposit of aerosol particles on a piezoelectric oscillating crystal and the determination of the oscillation parameters of the piezoelectrically stimulated oscillation of the crystal. In order to assure the required reproducibility reliably and independently of the type of aerosol particles, and thus to achieve a high quality of measurements, the piezoelectric crystal is charged to oscillation during less than half the period of deposit of aerosol particles.

Abstract: An arrangement is described for the quantitative and qualitative analysis of particles in gases, especially of particles in the exhaust gas of internal combustion engines, comprising a vibrating system with at least one vibration sensor, preferably a piezoelectric resonator, which is provided with at least one collecting surface for the particles to be analyzed, a circuit for the determination of characteristic vibration parameters as well as guide and transport arrangements for the gas to be analyzed. In order to obtain as large as possible a measuring range with a linear characteristic line and therewith a great sensitivity and dynamics with respect to the mass load in the entire measuring range, there is provided a vibration sensor stationary relative to the measuring chamber, and at least one active deflecting device for the gas or the particles contained in the gas.

Abstract: A separating device for connection to a rotating magazine. The separating device transports rivets (3) via a conveyor duct (6) formed by three limiting faces. The first limiting face is a base plate (5), the second limiting face is a right-hand guide segment (1) and the third limiting face is a left-hand guide segment (2). At least one of the guide segments is designed and arranged to be excited and oscillate to avoid jamming of rivets (3) in the conveyor duct (6).