Abstract: The present invention relates to the cloning and expression of foreign protein or polypeptides in bacteria, such as Escherichia coli. In particular, this invention relates to expression tools comprising a FKBP-type peptidyl prolyl isomerase selected from the group consisting of FkpA, SlyD, and trigger factor; methods of recombinant protein expression, the recombinant polypeptides thus obtained, as well as to the use of such polypeptides.

Abstract: The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein-(or transmembrane glycoprotein)-chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N-helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively, are also described.

Abstract: The invention disclosed relates to a soluble rubella E1 antigen and variants of this peptide characterized by lacking at the C-terminal end at least the transmembrane region and the anchor segment as well as at least the amino acids 143 to 164 and containing at least the region spanning the disulfide bridges Cys 349-Cys 352 and Cys 368-401 whereas the N-terminus (Cys 349) of this region contains additionally at least 15 amino acids and/or the C-terminus (Cys 401) of this region contains additionally at least 8 amino acids of the adjacent rubella E1 antigen sequence. Also described are a recombinant DNA molecule encoding the rubella E1 antigen and variants which are recombinantly expressed as a chaperone fusion protein, refolded into a soluble and immunoreactive conformation, and further used for the serological detection of anti-rubella antibodies.

Abstract: The present invention concerns a cement additive containing copolymers comprising one or more constitutional units represented by formula A: (A) R1 is hydrogen, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 1 to 4 carbon atoms or an aryl group having 6 to 9 carbon atoms; R2 is hydrogen or an alkyl group having 1 to 9 carbon atoms, an alkenyl group having 1 to 9 carbon atoms or an aryl group having 6 to 9 carbon atoms; T is alkylene (including straight-chain and branched alkylene) having 1 to 4 carbon atoms or arylene having 6 to 9 carbon atoms; n is 0 or 1; S1 and S2 are, independently of one another, —OCkH2k— or —OCH2CHR3—, with the proviso that k is 2 or 3, R3 is an alkyl group having 1 to 9 carbon atoms, an aryl group having 6 to 9 carbon atoms; and 6<_m1+m2<_25.

Abstract: The present invention relates to the diagnosis of Alzheimer's Disease. It especially teaches the production of a soluble A?-chaperone complex and the advantageous use of such chaperone-A? complex, especially in the detection of A? in an immunoassay, as well as its use as an immunogen.

Abstract: The present invention relates to the diagnosis of transmissible spongiform encephalopathies (TSEs). It especially teaches the production of a soluble prion protein (PrP)-chaperone complex and the advantageous use of such chaperone-PrP complex, especially in the detection of PrP in an immunoassay, as well as its use as and immunogen.

Abstract: A security translator (STL) that serves for connecting a data network (N2) pertaining to a lower security level to a data network (N1) pertaining to a higher security level examines its own integrity at definite intervals in order to ascertain malfunctions and, where appropriate, to trigger a transition to the secure failure state. The secure failure state consists in the connection from the data network with a lower security level to the data network with a higher security level being interrupted. This is obtained by means of a watchdog circuit (WD1, WD2) which keeps the connection (CTN) between the data network (N2) with a lower security level and the data network (N1) with a higher security level closed as long as it receives regular signs of life and which automatically interrupts the connection if it receives no sign of life over a predetermined period.

Abstract: In a method and device to control a print process in a printer or copier, with a character generator generating a latent print image and a latent toner marking on an image carrier. An exposure energy per unit area for the generation of the latent toner marking is decreased in comparison to an energy per unit area for generation of the latent print image. The latent print image and the latent toner marking are developed with toner in the developer station. An optical reflection sensor determines color density of the developed toner marking. Toner concentration is adjusted in a developer station dependent on a signal of the reflection sensor.

Abstract: The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein- (or transmembrane glycoprotein)-chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N-helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively, are also described.

Abstract: The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein-(or transmembrane glycoprotein)-chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N-helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively, are also described.

Abstract: The present invention relates to a beam-guiding and/or frequency-converting optical system as well as to a method of manufacturing same, wherein a beam-emitting optoelectronic component (1), which comprises at least one beam-emerging surface (2) for the emergence of a beam, is provided and connected to a surface (5) of a base (4) in such a manner that the emerging beam extends approximately in parallel with the surface (5) of said base (4). Once the optoelectronic component (1) has been connected to said base (4), a wave-guiding stratified system (4) is deposited and structured and/or locally modified on the surface (5) of said base (4) for guidance and/or frequency conversion of the beam in such a way that a gap-free contact is created between said beam exit surface (2) and said stratified (6) and a pre-determinable beam guidance is achieved.

Abstract: The present invention relates to the diagnosis of Alzheimer's Disease. It especially teaches the production of a soluble A?-chaperone complex and the advantageous use of such chaperone-A? complex, especially in the detection of A? in an immunoassay, as well as its use as an immunogen.

Abstract: Apparatus for dosing gaseous and/or vaporous substances An apparatus for dosing gaseous and/or vaporous substances, in particular for generating varying scents, includes a multitude of packaged storage containers (1) from which different gases and/or vapors are driven out by a carrier medium. On their inlet sides, the storage containers are connected to a common carrier medium manifold (13) via a shut-off device (4) assigned to each storage container that can be actuated, and on their outlet sides to a joint homogenization chamber (8). Both the carrier medium manifold and the homogenization chamber are connected to a carrier medium source using a regulating valve (5, 9). Check valves (6, 7) are integrated in the gas passages to the storage container and from the storage container to the homogenization chamber. A dosing apparatus designed based on this principle is characterized by low space requirements and materially separate volume flows that can be exactly timed and dosed.

Abstract: In a method and device to control a print process in a printer or copier, with a character generator generating a latent print image and a latent toner marking on an intermediate carrier. An exposure energy per area unit for the generation of the latent toner marking is decreased in comparison to an energy per area unit for generation of the latent print image. The latent print image and the latent toner marking are inked with toner in the developer station. An optical reflection sensor determines color density of the ink toner marking. Toner concentration is adjusted in a developer station dependent on a signal of the reflection sensor.

Abstract: The present invention relates to the diagnosis of transmissible spongiform encephalopathies (TSEs). It especially teaches the production of a soluble prion protein (PrP)-chaperone complex and the advantageous use of such chaperone-PrP complex, especially in the detection of PrP in an immunoassay, as well as its use as an immunogen.

Abstract: The device serves for changing the length of a running path of an electromagnetic wave. It comprises a wave guide which is wound onto a core. The core is formed in two parts, wherein the distance of the core parts to one another is changeable in order to extend the wave length in a defined manner.

Abstract: A gas turbine with axially mutually displaceable guide parts that compensates for differing amounts of thermal expansion, comprising guide parts which can be displaced with respect to one another in the axial direction and enclose a funnel-like gas duct from outside. In order to optimize a rotor blade tip gap, at least one of the funnel-like guide parts under control by means of a motor can be displaced. As a result of the axial displacement, because of the funnel-like shape of the guide parts, the width of the rotor blade tip gap is changed.

Abstract: The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein- (or transmembrane glycoprotein)-chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N-helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively, are also described.

Abstract: The present invention relates to the cloning and expression of foreign protein or polypeptides in bacteria, such as Escherichia coli. In particular, this invention relates to expression tools comprising a FKBP-type peptidyl prolyl isomerase selected from the group consisting of FkpA, SlyD, and trigger factor; methods of recombinant protein expression, the recombinant polypeptides thus obtained, as well as to the use of such polypeptides.

Abstract: A gas turbine with axially mutually displaceable guide parts that compensates for differing amounts of thermal expansion, comprising guide parts which can be displaced with respect to one another in the axial direction and enclose a funnel-like gas duct from outside. In order to optimize a rotor blade tip gap, the invention proposes to displace at least one of the funnel-like guide parts under control by means of a motor. As a result of the axial displacement, because of the funnel-like shape of the guide parts, the width of the rotor blade tip gap is changed.