Abstract: This disclosure relates generally to proteins target tumor cell killing comprising: a polypeptide or complex of two or more polypeptides that specifically binds ROR1, and a polypeptide or complex of two or more polypeptides that specifically binds CD3. In some embodiments, the present application provides antibodies that specifically bind ROR1. In some embodiments the application also provides therapeutic methods for using such proteins in the treatment of a cancer.

Abstract: The invention relates to EGFR targeting Fc antigen binding fragment-drug conjugates (EGFR Fcab-drug conjugates) and the use of the EGFR Fcab-drug conjugates of the present invention for the treatment and/or prevention of hyperproliferative diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such EGFR Fcab-drug conjugates. Further, the invention relates to EGFR Fcab-label conjugates and diagnostic compositions containing such EGFR Fcab-label conjugates.

Abstract: A computed tomography device includes a holding frame and a ring mount, being movably mounted to the holding frame. The ring mount includes an x-ray detector, with a semiconductor material, operable in an equilibrium of statistical states of occupation. In an embodiment, the computed tomography device includes a first power supply, set up to supply power, in an operating state of the computed tomography device, to a first lot of components of the computed tomography device, the first lot of components being arranged on the ring mount for an image generation process; and a second power supply, separable from the first power supply in terms of circuitry, to supply power to a second lot of components of the computed tomography device in a resting state of the computed tomography device, the components of the second lot being set up to hold the semiconductor material in the equilibrium.

Abstract: The invention relates to a disc brake, comprising a brake carrier, a brake caliper, brake shoes, and an actuating piston. The brake carrier has at least one mounting point for mounting on a vehicle. The actuating piston is displaceably accommodated on the brake caliper and is actuatable for carrying out a service brake function of the disc brake. At least one further actuating piston is provided, which in the direction of its longitudinal axis is displaceably accommodated on the brake caliper. For carrying out the service brake function, the at least two actuating pistons are actuatable, and for carrying out a parking brake function, one of the actuating pistons is actuatable. The invention further relates to a disc brake system and a parking brake system.

Abstract: A brake caliper arrangement includes a housing, a restoring device, a first brake lining arrangement and a second brake lining arrangement. The first brake lining arrangement and the second brake lining arrangement can be moved relative to one another from a respective starting position with a reduction of an initial spacing which exists between them. The restoring device includes first and second restoring elements. The first restoring element may prestress the first brake lining arrangement into its starting position, while the second restoring element may prestress the second brake lining arrangement into its starting position. The first and/or second restoring elements may be supported, on both sides of a central region of the brake lining arrangement, on the associated brake lining arrangement. The first and/or second restoring elements may be twisted elastically at least in sections in order to generate the prestress.

Abstract: A computed tomography device includes a holding frame and a ring mount, being movably mounted to the holding frame. The ring mount includes an x-ray detector, with a semiconductor material, operable in an equilibrium of statistical states of occupation. In an embodiment, the computed tomography device includes a first power supply, set up to supply power, in an operating state of the computed tomography device, to a first lot of components of the computed tomography device, the first lot of components being arranged on the ring mount for an image generation process; and a second power supply, separable from the first power supply in terms of circuitry, to supply power to a second lot of components of the computed tomography device in a resting state of the computed tomography device, the components of the second lot being set up to hold the semiconductor material in the equilibrium.

Abstract: A counting x-ray detector includes a converter element, a rewiring unit and an evaluation unit including pixel electrodes. In an embodiment, the converter element includes a first electrode on a surface facing away from the evaluation unit and a pixelated second electrode having a plurality of electrode elements on a surface facing toward the evaluation unit. The rewiring unit is on a surface of the converter element facing toward the evaluation unit. First contacts of electrically conductive connections between the electrode elements and the pixel electrodes are provided on a surface of the rewiring unit and include a first areal distribution; and second such contacts are provided on a surface of the rewiring unit, including a relatively smaller second areal distribution. An areal extent of the evaluation unit is relatively smaller than an areal extent of the converter element.

Abstract: A brake caliper arrangement includes a housing, a restoring device, a first brake lining arrangement and a second brake lining arrangement. The first brake lining arrangement and the second brake lining arrangement can be moved relative to one another from a respective starting position with a reduction of an initial spacing which exists between them. The restoring device includes first and second restoring elements. The first restoring element may prestress the first brake lining arrangement into its starting position, while the second restoring element may prestress the second brake lining arrangement into its starting position. The first and/or second restoring elements may be supported, on both sides of a central region of the brake lining arrangement, on the associated brake lining arrangement. The first and/or second restoring elements may be twisted elastically at least in sections in order to generate the prestress.

Abstract: The invention relates to a disc brake, comprising a brake carrier, a brake caliper, brake shoes, and an actuating piston. The brake carrier has at least one mounting point for mounting on a vehicle. The actuating piston is displaceably accommodated on the brake caliper and is actuatable for carrying out a service brake function of the disc brake. At least one further actuating piston is provided, which in the direction of its longitudinal axis is displaceably accommodated on the brake caliper. For carrying out the service brake function, the at least two actuating pistons are actuatable, and for carrying out a parking brake function, one of the actuating pistons is actuatable. The invention further relates to a disc brake system and a parking brake system.

Abstract: A detector is disclosed for detecting X-ray and/or gamma radiation, including a scintillator element for converting the X-ray and/or gamma radiation into light. The scintillator element has at least one side surface, an upper side and a lower side, a first photodiode on the lower side of the scintillator element. The detector further includes an electronic evaluation device, a light source designed to illuminate the scintillator element, and a light-impermeable housing which surrounds the scintillator element, the first photodiode, the electronic evaluation device and the light source.

Abstract: An X-ray detector includes a stack arrangement with a scattered radiation grid and a planar converter element including a first surface and a second surface. The converter element includes a first electrode embodied on the first surface and a pixelated second electrode with two adjacent first electrode elements. The two adjacent first electrode elements include a first width and a first length and the two adjacent first electrode elements are embodied the second surface opposite the first surface. The scattered radiation grid includes a grid wall with a thickness along the boundary between the two adjacent first electrode elements. The grid wall is arranged to be substantially perpendicular on the first surface and, in a projection, substantially parallel to the direction of incidence of the radiation and to the surface normal of the first surface. The grid wall at least partially overlaps the two adjacent first electrode elements.

Abstract: A method is described for determining the polarization state of a sensor of an X-ray detector. In the method, the X-ray detector is illuminated with a sequence of light pulses wherein the individual pulses of the light pulse sequence have a different intensity. It is further determined at what intensity of the light pulses, charge pulses generated by the sensor of the X-ray detector exceed a threshold voltage of a signal detection circuit. Also described is a method for obtaining and/or setting functional data of a sensor of an X-ray detector and/or of a sensor illumination unit. Furthermore, an X-ray detector is described.

Abstract: The invention relates to anti-TNF? antibodies which are engineered to exhibit a pH-sensitive antigen binding. The invention is preferably directed to anti-TNF? antibody adalimumab (Humira®) or biologically active variants and fragments thereof, wherein the original adalimumab antibody or variant or fragment thereof is engineered by modifications of amino acid sequence within the variable regions. Specifically, the invention relates to adalimumab or biologically active variants or fragments thereof, wherein the CDR domains are modified by replacing one or more amino acid residues by histidine residues.

Abstract: A counting x-ray detector includes a converter element, a rewiring unit and an evaluation unit including pixel electrodes. In an embodiment, the converter element includes a first electrode on a surface facing away from the evaluation unit and a pixelated second electrode having a plurality of electrode elements on a surface facing toward the evaluation unit. The rewiring unit is on a surface of the converter element facing toward the evaluation unit. First contacts of electrically conductive connections between the electrode elements and the pixel electrodes are provided on a surface of the rewiring unit and include a first areal distribution; and second such contacts are provided on a surface of the rewiring unit, including a relatively smaller second areal distribution. An areal extent of the evaluation unit is relatively smaller than an areal extent of the converter element.

Abstract: A method is for the production of a scintillator fiber. In an embodiment, the method includes provisioning a suspension of a binder dissolved in a solvent and a scintillator material; and pressing the suspension into a precipitation bath in which the binder is insoluble.

Abstract: A method is for the production of a scintillator fiber. In an embodiment, the method includes provisioning a suspension of a binder dissolved in a solvent and a scintillator material; and pressing the suspension into a precipitation bath in which the binder is insoluble.

Abstract: The invention relates to anti-TNFa antibodies which are engineered to exhibit a pH-sensitive antigen binding. The invention is preferably directed to anti-TNFa antibody adalimumab (Humira®) or biologically active variants and fragments thereof, wherein the original adalimumab antibody or variant or fragment thereof is engineered by modifications of amino acid sequence within the variable regions. Specifically, the invention relates to adalimumab or biologically active variants or fragments thereof, wherein the CDR domains are modified by replacing one or more amino acid residues by histidine residues.

Abstract: An x-ray radiation detector is disclosed with an upper side, which faces an x-ray radiation source during operation, and with a semiconductor layer for direct conversion of x-ray radiation into electric measurement signals. In an embodiment, a luminous film is arranged between the upper side and the semiconductor layer, and with the aid of which luminous film, electromagnetic radiation can be coupled into the semiconductor layer.

Abstract: A detector is disclosed for detecting X-ray and/or gamma radiation, including a scintillator element for converting the X-ray and/or gamma radiation into light. The scintillator element has at least one side surface, an upper side and a lower side, a first photodiode on the lower side of the scintillator element. The detector further includes an electronic evaluation device, a light source designed to illuminate the scintillator element, and a light-impermeable housing which surrounds the scintillator element, the first photodiode, the electronic evaluation device and the light source.

Abstract: A method is described for determining the polarization state of a sensor of an X-ray detector. In the method, the X-ray detector is illuminated with a sequence of light pulses wherein the individual pulses of the light pulse sequence have a different intensity. It is further determined at what intensity of the light pulses, charge pulses generated by the sensor of the X-ray detector exceed a threshold voltage of a signal detection circuit. Also described is a method for obtaining and/or setting functional data of a sensor of an X-ray detector and/or of a sensor illumination unit. Furthermore, an X-ray detector is described.