Abstract: The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.

Abstract: The present invention relates to compounds of formula (Ia) and the use thereof as inhibitors of P. aeruginosa virulence factor LasB. Formula (Ia). These compounds are useful in the treatment of bacterial infections, especially caused by P. aeruginosa.

Abstract: The present invention relates to a compounds according to general formula (I), which acts as an inverse agonist of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS), sometimes also referred to as MvfR); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonasaeruginosa or Burkholderia infection.

Abstract: The present invention relates to a compound according to general formula (I), which acts as an inverse agonist of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS), sometimes also referred to as MvfR); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.

Abstract: The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.

Abstract: In the method, a portion of the metal tube is placed in a lumen of a metal sleeve having a metal wall surrounding the lumen. The metal tube is placed in such a manner that an outer surface of the metal tube and an inner surface of the metal sleeve at least partially contact one another. The metal sleeve is affixed on the portion of the metal tube placed in its lumen for forming a metal tube, metal sleeve, composite system. The metal tube, metal sleeve, composite system, in turn, is placed in the passageway of the metal body in such a manner that an outer surface of the metal sleeve and an inner surface of the passageway at least partially contact one another, in order thereafter by plastically deforming at least the metal sleeve of the metal tube, metal sleeve, composite system placed in the passageway to form a force interlocking between the inner surface of the passageway and the outer surface of the metal sleeve.

Abstract: A measuring transducer for registering and/or monitoring at least one process variable of a flowable medium guided in a pipeline, which at least includes: a housing module, which is mechanically coupled with the pipeline via an inlet end and an outlet end, and a sensor module having at least one measuring tube held oscillatably at least partially in the housing module and caused, at least at times, to oscillate. The at least one component of the housing module and/or of the sensor module is manufactured by means of a generative method and method for manufacturing at least one component of a measuring transducer, which method includes manufacturing the at least one component by means of a primary forming process, especially by means of a layered applying and/or melting-on of a powder, especially a metal powder, based on a digital data set, which gives at least the shape and/or the material and/or the structure of the at least one component.

Abstract: A measuring transducer for registering and/or monitoring at least one process variable of a flowable medium guided in a pipeline, which at least includes: a housing module, which is mechanically coupled with the pipeline via an inlet end and an outlet end, and a sensor module having at least one measuring tube held oscillatably at least partially in the housing module and caused, at least at times, to oscillate. The at least one component of the housing module and/or of the sensor module is manufactured by means of a generative method and method for manufacturing at least one component of a measuring transducer, which method includes manufacturing the at least one component by means of a primary forming process, especially by means of a layered applying and/or melting-on of a powder, especially a metal powder, based on a digital data set, which gives at least the shape and/or the material and/or the structure of the at least one component.

Abstract: The measuring transducer comprises a measuring tube having an inlet-side tube end and an outlet-side tube end, a tube wall having a predetermined wall thickness and a lumen surrounded by the tube wall and extending between the first and second tube end, a support element, which with a support end is mechanically connected with the tube end and with a support end is mechanically connected with the tube end, as well as, laterally spaced from the measuring tube, a support element, which with a support end is mechanically connected with the support end and with a support end is mechanically connected with the support end. The measuring tube of the measuring transducer is adapted to guide a flowing medium in its lumen and during that to be caused to oscillate about a static resting position for producing Coriolis forces. The measuring transducer comprises an oscillation exciter as well as at least one oscillation sensor.

Abstract: A measuring transducer comprises a measuring tube having an inlet-side tube end and an outlet-side tube end, a tube wall having a predetermined wall thickness and a lumen surrounded by the tube wall and extending between the first and second tube end, a support element, which with a support end is mechanically connected with the tube end and with a support end is mechanically connected with the tube end, as well as, laterally spaced from the measuring tube, a support element, which with a support end is mechanically coupled with the support end and with a support end is mechanically coupled with the support end. The measuring tube is adapted to guide a flowing medium in its lumen and caused to oscillate about a static resting position for producing Coriolis forces. An oscillation exciter as well as at least one oscillation sensor.

Abstract: The measuring transducer comprises: a transducer housing (71), of which an inlet-side, housing end is formed by means of an inlet-side, flow divider (201) having four flow openings (201A, 201B, 201C, 201D) and an outlet-side, housing end is formed by means of an outlet-side, flow divider (202) having four flow openings (202A, 202B, 202C, 202D); as well as a tube arrangement having four, curved, or bent, measuring tubes (181, 182, 183, 184) connected to the flow dividers (201, 202) for guiding flowing medium along flow paths connected in parallel, wherein each of the four measuring tubes opens with an inlet-side, measuring tube end into one of the flow openings of the flow divider (201) and with an outlet-side, measuring tube end into one the flow openings of the flow divider (202). The transducer further comprises an exciter mechanism for exciting oscillations of said measuring tube.

Abstract: A measuring transducer comprises a measuring tube having an inlet-side tube end and an outlet-side tube end, a tube wall having a predetermined wall thickness and a lumen surrounded by the tube wall and extending between the first and second tube end, a support element, which with a support end is mechanically connected with the tube end and with a support end is mechanically connected with the tube end, as well as, laterally spaced from the measuring tube, a support element, which with a support end is mechanically coupled with the support end and with a support end is mechanically coupled with the support end. The measuring tube is adapted to guide a flowing medium in its lumen and caused to oscillate about a static resting position for producing Coriolis forces. An oscillation exciter as well as at least one oscillation sensor.

Abstract: A measuring transducer comprises: a housing, with an inlet-side flow divider having four flow openings, and an outlet-side end having four flow openings; a tube arrangement having four tubes connected to the flow dividers; and a first coupling element. An exciter mechanism for producing and/or maintaining mechanical oscillations of the four measuring tubes. The first coupling element includes a deformation body and four connecting struts, of which connected with a first strut end and with the first measuring tube, a second connecting strut is connected with a first strut end and with a second strut end with the second measuring tube, a third connecting strut and with a second strut end with the first measuring tube, and a fourth connecting strut is connected with a first strut end and with a second strut end with the fourth measuring tube.

Abstract: A measuring transducer having exactly four flow openings, and an outlet-side housing end formed by means of an outlet-side flow divider having exactly four flow openings. A tube arrangement has exactly four curved or bent measuring tubes connected to the flow dividers for guiding flowing medium along flow paths connected in parallel. Each of the four measuring tubes opens with an inlet-side measuring tube end into one of the flow openings of the inlet-side flow divider, and with an outlet-side measuring tube end into one of the flow openings of the outlet-side flow divider. A first coupling element for adjusting eigenfrequencies of natural oscillation modes of the tube arrangement. An electro-mechanical exciter mechanism of the measuring transducer serves for producing and/or maintaining mechanical oscillations of the four measuring tubes.

Abstract: The measuring transducer comprises: a transducer housing (71), of which an inlet-side, housing end is formed by means of an inlet-side, flow divider (201) having four flow openings (201A, 201B, 201C, 201D) and an outlet-side, housing end is formed by means of an outlet-side, flow divider (202) having four flow openings (202A, 202B, 202C, 202D); as well as a tube arrangement having four, curved, or bent, measuring tubes (181, 182, 183, 184) connected to the flow dividers (201, 202) for guiding flowing medium along flow paths connected in parallel, wherein each of the four measuring tubes opens with an inlet-side, measuring tube end into one of the flow openings of the flow divider (201) and with an outlet-side, measuring tube end into one the flow openings of the flow divider (202). The transducer further comprises an exciter mechanism for exciting oscillations of said measuring tube.

Abstract: A measuring transducer comprises a transducer housing, of which an inlet-side housing end is formed by means of an inlet-side flow divider having eight, mutually spaced flow openings and an outlet-side housing end is formed by means of an outlet-side flow divider having eight, mutually spaced flow openings as well as a tube arrangement with eight bent measuring tubes for the conveying flowing medium, which, forming flow paths connected for parallel flow, are connected to the flow dividers, wherein each of the eight measuring tubes in each case opens with an inlet-side measuring tube end into one of the flow openings of the flow divider, and in each case opens with an outlet-side measuring tube end into one of the flow openings of the flow divider. An electro-mechanical exciter mechanism of the measuring transducer serves for producing and/or maintaining mechanical oscillations of the measuring tubes.

Abstract: An insulating body is captively secured on the housing for a plug connection having insulation displacement terminals. The insulating body is held on guide of the housing in a rotatable manner and in an insertable manner into the housing via an opening. The guide can be formed as slits that lie in lateral parts of the housing. The lateral parts project beyond the housing. Electric conductors can be inserted into the insulating body on a rear surface, plugged through said body, and cut on a front surface. The electric conductors are thus brought to the intended length before the insulating body is inserted into the housing.

Abstract: A measuring transducer comprises: a transducer housing, of which an inlet-side is formed by means of an inlet-side, flow divider having exactly four flow openings spaced from one another and an outlet-side formed by means of an outlet-side, flow divider having exactly four flow openings from one another; a tube arrangement having exactly four, curved, or bent, measuring tubes connected to the flow dividers for guiding flowing medium along flow paths connected in parallel. Each of the four measuring tubes opens with an inlet-side, measuring tube end into one of the flow openings of the flow divider and with an outlet-side, measuring tube end into one the flow openings of the flow divider. Two flow dividers are arranged in the measuring transducer. An electromechanical exciter mechanism is provided.

Abstract: A measuring transducer having exactly four flow openings, and an outlet-side housing end formed by means of an outlet-side flow divider having exactly four flow openings. A tube arrangement has exactly four curved or bent measuring tubes connected to the flow dividers for guiding flowing medium along flow paths connected in parallel. Each of the four measuring tubes opens with an inlet-side measuring tube end into one of the flow openings of the inlet-side flow divider, and with an outlet-side measuring tube end into one of the flow openings of the outlet-side flow divider. A first coupling element for adjusting eigenfrequencies of natural oscillation modes of the tube arrangement. An electro-mechanical exciter mechanism of the measuring transducer serves for producing and/or maintaining mechanical oscillations of the four measuring tubes.

Abstract: The measuring transducer comprises: a transducer housing, of which an inlet-side, housing end is formed by means of a flow divider including four flow openings spaced, and an outlet-side, formed by means of a flow divider including four flow openings spaced, from one another. A tube arrangement including four curved measuring tubes connected to the flow dividers for guiding flowing medium along flow paths connected in parallel. Each measuring tubes opens with an inlet-side, measuring tube end into one of the flow openings of the flow divider and with an outlet-side, measuring tube end into one the flow openings of the flow divider. The two flow dividers are embodied and arranged in the measuring transducer, so that the tube arrangement extends both between a first and a second of the measuring tubes and between a third and a fourth of the measuring tubes.