Patents by Inventor Christian Simonot

Christian Simonot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gadolinium complex tetramides and use in medical imaging
    Patent number: 6827927
    Abstract: The invention concerns a racemic compound of the pair of enantiomers of formula (III) wherein R represents an alkyl group or a phenyl group optionally substituted.
    Type: Grant
    Filed: November 21, 2001
    Date of Patent: December 7, 2004
    Assignee: Guerbet
    Inventors: Olivier Rousseaux, Christian Simonot
  • Metal chelates of substituted polyaminocarboxylic macrocycles and their use in diagnostic imaging
    Patent number: 6187285
    Abstract: Chelates of the compounds of formula I in which R is a hydrophilic group containing 3 or 4 successive phenyl rings and m is 1 or 2, with metal ions, for use in diagnostic imaging.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: February 13, 2001
    Assignee: Guerbet
    Inventors: Dominique Meyer, Marc Port, Olivier Rousseaux, Christian Simonot
  • Polyaminated ligands and metal complexes thereof
    Patent number: 5919432
    Abstract: Poly(amino acid) derivatives, which are chelating agents of paramagnetic metal ions, in which at least 3 of the donor nitrogen atoms carry identical or different substituents, of formulaCH(R.sub.1)--X,in which X represents CO.sub.2 R.sub.a, CONR.sub.b R.sub.c or P(R.sub.d)O.sub.2 H and R.sub.a, R.sub.b and R.sub.c, which are identical or different, represent H or optionally hydroxylated (C.sub.1 -C.sub.8)alkyl, R.sub.d represents OH, (C.sub.1 -C.sub.8)alkyl or (C.sub.1 -C.sub.8)alkoxy and R.sub.1 represents a hydrophilic group with a molecular weight greater than 200 containing at least 3 oxygen atoms, with the proviso that at least 3 of the X groups are optionally salified acid functional groups.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: July 6, 1999
    Assignee: Guerbet S.A.
    Inventors: Dominique Meyer, Olivier Rousseaux, Michel Schaefer, Christian Simonot
  • Metal complexes of polyamino oxides, and their utilization in diagnostic imaging
    Patent number: 5886158
    Abstract: The invention concerns gadolinium complexes of formula: ##STR1## in which R represents a group of formula: ##STR2## in which X is Br or I; R.sub.1 is H or optionally hydroxylated alkyl;R.sub.2 is hydroxylated alkyl; oralternatively R.sub.1 is H and R.sub.2 is a group of formula: ##STR3## X being as defined above, and R'.sub.1 and R'.sub.2 being as defined for R.sub.1 and R.sub.2 excepted that they do not represent A, provided that --CO--NR.sub.1 R.sub.2 or --CO--NR'.sub.1 R'.sub.2 comprises at least 2 hydroxyl groups, and M represents H or the cation of an inorganic or organic base.
    Type: Grant
    Filed: December 29, 1997
    Date of Patent: March 23, 1999
    Assignee: Guerbet S.A.
    Inventors: Dominique Meyer, Olivier Rousseaux, Michel Schaefer, Christian Simonot
  • Polyiodinated compounds, their preparation and their use as contrast media for radiology
    Patent number: 5817873
    Abstract: The present invention relates to polyiodinated compounds with a single molecular weight having a molecular concentration of iodine of greater than approximately 20% by weight, and in particular greater than approximately 30% by weight, containing at least 9 iodine atoms and having a molecular weight above 2000 and below approximately 50,000, and in particular above 2000 and below approximately 20,000, said compounds possessing either a zero overall electrical charge or at least two anionic charges, and persisting in the vascular compartment at a value equal to at least approximately 30% by weight of the injected dose in a subject five minutes after intravascular administration in the said subject.
    Type: Grant
    Filed: November 1, 1994
    Date of Patent: October 6, 1998
    Assignee: Guerbet S.A.
    Inventors: Dominique Meyer, Soizic le Greneur, Gael le Lem, Christian Simonot, Catherine Chambon
  • Polyaminated ligands and metal complexes thereof
    Patent number: 5712389
    Abstract: Poly(amino acid) derivatives, which are chelating agents of paramagnetic metal ions, in which at least 3 of the donor nitrogen atoms carry identical or different substituents, of formulaCH (R.sub.1) --X,in which X represents CO.sub.2 R.sub.a, CONR.sub.b R.sub.c or P(R.sub.d)O.sub.2 H and R.sub.a, R.sub.b and R.sub.c, which are identical or different, represent H or optionally hydroxylated (C.sub.1 -C.sub.8)alkyl, R.sub.d represents OH, (C.sub.1 -C.sub.8)alkyl or (C.sub.1 -C.sub.8)alkoxy and R.sub.1 represents a hydrophilic group with a molecular weight greater than 200 containing at least 3 oxygen atoms, with the proviso that at least 3 of the X groups are optionally salified acid functional groups.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: January 27, 1998
    Assignee: Guerbet S.A.
    Inventors: Dominique Meyer, Olivier Rousseaux, Michel Schaefer, Christian Simonot
  • Compounds which can be used in contrast products for radiography
    Patent number: 5609851
    Abstract: Polyiodinated nonionic compound that have the formula: ##STR1##
    Type: Grant
    Filed: November 21, 1994
    Date of Patent: March 11, 1997
    Assignee: Guerbet S A.
    Inventors: Fatima Z. Bennani, Soizic le Greneur, Christian Simonot, Dominique Meyer