Patents by Inventor Christian Steinkuehler

Christian Steinkuehler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240207228
    Abstract: The present invention relates to a combination comprising N-hydroxy-4-((5-(thiophen-2-yl)-1H-tetrazol-1-yl)methyl)benzamide or a pharmaceutically acceptable salt thereof and at least one CTLA4 checkpoint inhibitor, useful in the immunotherapy of tumors and in the treatment of one or more HDAC6-mediated diseases.
    Type: Application
    Filed: April 19, 2022
    Publication date: June 27, 2024
    Inventors: Gianluca FOSSATI, Flavio LEONI, Pietro Samuele POZZI, Elisabetta GALBIATI, Christian STEINKÜHLER
  • Publication number: 20230286970
    Abstract: The present invention relates to novel selective oxadiazole-based inhibitors of histone deacetylase 6 (HDAC6) bearing a pentaheterocyclic scaffold and pharmaceutical compositions thereof.
    Type: Application
    Filed: July 30, 2021
    Publication date: September 14, 2023
    Inventors: Mattia MARCHINI, Barbara VERGANI, Giovanni SANDRONE, Ilaria ROCCHIO, Georgii KACHKOVSKYI, Gianluca CAPRINI, Gianluca FOSSATI, Christian STEINKÜHLER, Andrea STEVENAZZI
  • Patent number: 11351178
    Abstract: The present invention relates to novel benzohydroxamic compounds of formula (I) and (II) and pharmaceutically acceptable salts, isomers and prodrugs thereof, exhibiting a high selective inhibitory activity against histone deacetylase 6 (HDAC6) enzyme.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: June 7, 2022
    Assignee: ITALFARMACO SPA
    Inventors: Barbara Vergani, Gianluca Caprini, Gianluca Fossati, Maria Lattanzio, Mattia Marchini, Gianfranco Pavich, Marcello Pezzuto, Chiara Ripamonti, Giovanni Sandrone, Christian Steinkühler, Andrea Stevenazzi
  • Publication number: 20210128577
    Abstract: The present invention relates to novel benzohydroxamic compounds of formula (1) and (II) and pharmaceutically acceptable salts, isomers and prodrugs thereof, exhibiting a high selective inhibitory activity against histone deacetylase 6 (HDAC6) enzyme.
    Type: Application
    Filed: April 12, 2018
    Publication date: May 6, 2021
    Inventors: Barbara VERGANI, Gianluca CAPRINI, Gianluca FOSSATI, Maria LATTANZIO, Mattia MARCHINI, Gianfranco PAVICH, Marcello PEZZUTO, Chiara RIPAMONTI, Giovanni SANDRONE, Christian STEINKÜHLER, Andrea STEVENAZZI
  • Patent number: 10745696
    Abstract: The present invention provides for a library of vectors comprising human HC-CDR3 regions of varying length, wherein the diversity of said library is focused on the HC-CDR3 region only and diversity has been optimized such that redundancy is reduced for short HC-CDR3 loops and coverage of HC-CDR3 region variants for longer loop lengths has been increased. The library of the present invention is displayed on phage for selection against target antigens.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: August 18, 2020
    Assignee: ITALFARMACO S.P.A.
    Inventors: Armin Lahm, Christian Steinkuehler, Gessica Filocamo
  • Patent number: 10590101
    Abstract: The present invention relates to new benzo-N-hydroxy amide compounds of formula (I) and pharmaceutically acceptable salts, isomers and prodrugs thereof, which show a significant inhibitory activity on the proliferation of tumor cells and specifically of cancer stem cells.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: March 17, 2020
    Assignee: ITALFARMACO SPA
    Inventors: Andrea Stevenazzi, Giovanni Sandrone, Daniela Modena, Samuele Pietro Pozzi, Barbara Vergani, Maria Lattanzio, Paolo Mascagni, Christian Steinkühler, Gianluca Fossati
  • Publication number: 20190300496
    Abstract: The present invention relates to new benzo-N-hydroxy amide compounds of formula (I) and pharmaceutically acceptable salts, isomers and prodrugs thereof, which show a significant inhibitory activity on the proliferation of tumor cells and specifically of cancer stem cells.
    Type: Application
    Filed: July 14, 2017
    Publication date: October 3, 2019
    Inventors: Andrea STEVENAZZI, Giovanni SANDRONE, Daniela MODENA, Samuele Pietro POZZI, Barbara VERGANI, Maria LATTANZIO, Paolo MASCAGNI, Christian STEINKÜHLER, Gianluca FOSSATI
  • Publication number: 20190211326
    Abstract: The present invention provides for a library of vectors comprising human HC-CDR3 regions of varying length, wherein the diversity of said library is focused on the HC-CDR3 region only and diversity has been optimized such that redundancy is reduced for short HC-CDR3 loops and coverage of HC-CDR3 region variants for longer loop lengths has been increased. The library of the present invention is displayed on phage for selection against target antigens.
    Type: Application
    Filed: February 14, 2019
    Publication date: July 11, 2019
    Inventors: Armin Lahm, Christian Steinkuehler
  • Patent number: 6197536
    Abstract: The process according to the present invention allows expression and isolation of polypeptides with the proteolytic activity of HCV NS3 protease in a pure, catalytically active form, and in amounts that are sufficient for discovery of NS3 protease inhibitors and for determination of the three-dimensional structure of the NS3 protease. A further subject of the present invention is a procedure that defines the chemical and physical conditions necessary for completion of the proteolytic activity of the above polypeptides. The invention further comprises new compositions of matter (expression vectors) containing nucleotide sequences capable of expressing the above mentioned polypeptides in culture cells. Finally, new compounds of matter are defined, suitable to measure the above proteolytic activity, and useful to develop NS3 protease inhibitors and therefore therapeutic agents for use against HCV. The figure shows the kinetic parameters of HCV NS3 protease using the S3 depsipeptide substrate (SEQ ID NO:45).
    Type: Grant
    Filed: February 23, 1998
    Date of Patent: March 6, 2001
    Assignee: Istituto di Ricerche di Biologia Moleculare S.p.A.
    Inventors: Christian Steinkühler, Antonello Pessi, Elisabetta Bianchi, Marina Taliani, Licia Tomei, Andrea Urbani, Raffaele De Francesco, Frank Narjes