Patents by Inventor Christian Wilke
Christian Wilke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11519863Abstract: The invention relates to a method in the preparation of samples for microscopic examination onto which a coverslip is applied. The method is notable for the fact that the coverslipping quality is checked automatically and at least partly optically. The invention further relates to an apparatus for carrying out the method, and to an apparatus for checking the coverslipping quality of samples onto which a coverslip is applied.Type: GrantFiled: December 13, 2017Date of Patent: December 6, 2022Assignee: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Bernhard Neef, Christian Wilke, Karl-Heinrich Westerhoff
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Publication number: 20220056414Abstract: The invention relates to a method for producing a material for preparing a substrate for cultivating living cells. The invention further relates to a platelet lysate material and its use.The solution of the problem underlying the invention is based on the combination of at least two different treatments with different virus inactivation procedures.Combining two or more procedures for inactivation of virus particles and/or virus components ensures that a wide range of viruses (e.g. enveloped and non-enveloped viruses) are inactivated so as to provide a safe product for clinical and pharmaceutical applications. Moreover, a platelet lysate material comprising blood platelet lysate is provided, wherein the material is a liquid or dry material that is essentially devoid of vims particles and/or virus components.Type: ApplicationFiled: August 23, 2019Publication date: February 24, 2022Applicant: PL BIOSCIENCE GMBHInventors: Hatim HEMEDA, Christian WILKES
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Publication number: 20200325442Abstract: The invention relates to a method for producing a material for preparing a three-dimensional, gel-like substrate, wherein a thrombocyte concentrate is provided and blood platelets are harvested from this thrombocyte concentrate. The blood platelets are then lysed so as to produce a platelet lysate, and said platelet lysate is subsequently lyophilized so as to provide a dry platelet lysate gel material. The invention further concerns a platelet lysate gel material comprising blood platelet lysate, wherein this material is a lyophilized dry material. The lyophilized gel can be easily reconstituted by the addition of water at the place of use in order to provide a completely functional platelet lysate-gel which can be used for cultivating living cells without any limitations. Accordingly, this method facilitates transportation of the gel material and ensures a higher shelf life of the platelet lysate gel without any impact on cell culture properties.Type: ApplicationFiled: June 1, 2016Publication date: October 15, 2020Applicants: PL BIOSCIENCE GMBH, PL BIOSCIENCE GMBHInventors: Hatim HEMEDA, Christian WILKES
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Patent number: 10046780Abstract: A method for operating a rail vehicle includes, at least to some extent, using a secondary ETCS device which travels along with the rail vehicle but is not used for its operation, if a fault occurs in a primary ETCS device. A secondary EVC takes over the role of a primary EVC and, in many applications, at least some train control functions. The advantage is that train control can, at least in some fault cases, be continued in an automated way in the case of a failure of a component of the primary ETCS device. A rail vehicle and an apparatus for the operation of a rail vehicle are also provided.Type: GrantFiled: September 5, 2013Date of Patent: August 14, 2018Assignee: Siemens AktiengesellschaftInventors: Markus Dymek, Carsten Hasselkuss, Udo Rabeneck, Christian Wilke
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Publication number: 20180100787Abstract: The invention relates to a method in the preparation of samples for microscopic examination onto which a coverslip is applied. The method is notable for the fact that the coverslipping quality is checked automatically and at least partly optically. The invention further relates to an apparatus for carrying out the method, and to an apparatus for checking the coverslipping quality of samples onto which a coverslip is applied.Type: ApplicationFiled: December 13, 2017Publication date: April 12, 2018Inventors: Bernhard Neef, Christian Wilke, Karl-Heinrich Westerhoff
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Patent number: 9880079Abstract: The invention relates to a method in the preparation of samples for microscopic examination onto which a coverslip is applied. The method is notable for the fact that the coverslipping quality is checked automatically and at least partly optically. The invention further relates to an apparatus for carrying out the method, and to an apparatus for checking the coverslipping quality of samples onto which a coverslip is applied.Type: GrantFiled: February 19, 2013Date of Patent: January 30, 2018Assignee: Leica Biosystems Nussloch GmbHInventors: Bernhard Neef, Christian Wilke, Karl-Heinrich Westerhoff
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Patent number: 9776647Abstract: A method for inputting ETCS data into a rail vehicle inputs the ETCS data by using an apparatus which is separate from the rail vehicle. The apparatus can, for example, be constructed to be mobile and the ETCS data can be input flexibly at different locations and be transmitted to the rail vehicle, for example, by SMS. The advantage of this approach is that delays resulting from the inputting of ETCS data can be reduced and thus the rail vehicle reaches a “Start of Mission” state more quickly. An apparatus for inputting ETCS data into a rail vehicle and a rail vehicle with an ETCS device are also provided.Type: GrantFiled: September 5, 2013Date of Patent: October 3, 2017Assignee: Siemens AktiengesellschaftInventors: Markus Dymek, Carsten Hasselkuss, Udo Rabeneck, Christian Wilke
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Patent number: 9733163Abstract: The present invention relates to a holding apparatus (10) for receiving specimen slides (1), having a holder (3, 4, 5) for handling the holding apparatus (10) and having at least two identification units (2a, 2b) that make available different information items to enable characterization of the orientation of the holding apparatus (10) in a stainer or coverslipper.Type: GrantFiled: March 10, 2016Date of Patent: August 15, 2017Assignee: Leica Biosystems Nussloch GmbHInventors: Markus Berberich, Christian Wilke, Jurgen Tenhaef
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Publication number: 20160187236Abstract: The present invention relates to a holding apparatus (10) for receiving specimen slides (1), having a holder (3, 4, 5) for handling the holding apparatus (10) and having at least two identification units (2a, 2b) that make available different information items to enable characterization of the orientation of the holding apparatus (10) in a stainer or coverslipper.Type: ApplicationFiled: March 10, 2016Publication date: June 30, 2016Inventors: Markus BERBERICH, Christian WILKE, Jurgen TENHAEF
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Patent number: 9322754Abstract: The present invention relates to a holding apparatus (10) for receiving specimen slides (1), having a holder (3, 4, 5) for handling the holding apparatus (10) and having at least two identification units (2a, 2b) that make available different information items to enable characterization of the orientation of the holding apparatus (10) in a stainer or coverslipper.Type: GrantFiled: December 7, 2011Date of Patent: April 26, 2016Assignee: Leica Biosystems Nussloch GmbHInventors: Markus Berberich, Christian Wilke, Jürgen Tenhaef
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Patent number: 9157782Abstract: The present invention relates to a coverslipping machine (1) including: a hollow needle (2) for applying mounting medium onto a specimen slide (5); a transparent container (103) to be filled with a liquid; a light source (101) for radiating measurement light in a principal radiating direction (A) into the container (103); and a light sensor (102, 102?) for detecting the measurement light, the light source (101) being arranged with respect to the container (103) in such a way that the radiated measurement light is refracted by a liquid in the container whose fill level exceeds a fill level limit, the light sensor (102, 102?) being arranged with respect to the container (103) in such a way that only measurement light refracted by the liquid or only measurement light not refracted by the liquid is detected.Type: GrantFiled: March 1, 2013Date of Patent: October 13, 2015Assignee: Leica Biosystems Nussloch GmbHInventors: Markus Berberich, Christian Wilke, Tobias Trump
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Publication number: 20150239481Abstract: A method for operating a rail vehicle includes, at least to some extent, using a secondary ETCS device which travels along with the rail vehicle but is not used for its operation, if a fault occurs in a primary ETCS device. A secondary EVC takes over the role of a primary EVC and, in many applications, at least some train control functions. The advantage is that train control can, at least in some fault cases, be continued in an automated way in the case of a failure of a component of the primary ETCS device. A rail vehicle and an apparatus for the operation of a rail vehicle are also provided.Type: ApplicationFiled: September 5, 2013Publication date: August 27, 2015Inventors: Markus Dymek, Carsten Hasselkuss, Udo Rabeneck, Christian Wilke
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Publication number: 20150232109Abstract: A method for inputting ETCS data into a rail vehicle inputs the ETCS data by using an apparatus which is separate from the rail vehicle. The apparatus can, for example, be constructed to be mobile and the ETCS data can be input flexibly at different locations and be transmitted to the rail vehicle, for example, by SMS. The advantage of this approach is that delays resulting from the inputting of ETCS data can be reduced and thus the rail vehicle reaches a “Start of Mission” state more quickly. An apparatus for inputting ETCS data into a rail vehicle and a rail vehicle with an ETCS device are also provided.Type: ApplicationFiled: September 5, 2013Publication date: August 20, 2015Inventors: Markus Dymek, Carsten Hasselkuss, Udo Rabeneck, Christian Wilke
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Patent number: 8894644Abstract: A method and device for treatment of living cells with cold atmospheric pressure plasma while simultaneously applying selective electroporation of the cells are provided. The method is useful for the local selective killing of cancer cells, improvement of wound treatment and sterilization or decontamination of objects.Type: GrantFiled: August 12, 2010Date of Patent: November 25, 2014Assignee: INP Greifswald Leibniz-Inst fuer PlasmaforschungInventors: Manfred Stieber, Klaus-Dieter Weltmann, Thomas Von Woedtke, Christian Wilke, Uwe Ehrenberg
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Patent number: 8662818Abstract: The invention relates to apparatuses for turning racks (1) for specimen slides (4), having a rack receptacle for at least one rack, the rack (1) being oriented in the rack receptacle horizontally in a first position such that specimen slides in the rack are arranged vertically next to one another relative to a longitudinal axis of the rack, and the rack receptacle being pivotable around a rotation axis (8) into a second position in which the rack (1) is oriented vertically. The rotation axis (8) of the rack (1) extends obliquely with respect to the longitudinal axis (5) of the horizontally oriented rack (1), so that the rack (1) can be pivoted back and forth between the first and the second position by means of a 180-degree rotation around the rotation axis (8).Type: GrantFiled: December 12, 2011Date of Patent: March 4, 2014Assignee: LEICA Biosystems Nussloch GmbHInventor: Christian Wilke
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Patent number: 8540947Abstract: During operation of a staining device (20) including a first container (22) filled with a first process medium (23) and a second container (24) filled with a second process medium (25), samples (26) to be stained are immersed in the first process medium (23). A speed representative of how fast the samples (26) are to be withdrawn from the first process medium (23) is determined according to the first process medium (23) and/or according to the samples (26). Subsequently, the samples (26) are withdrawn from the first process medium (23) at the determined speed.Type: GrantFiled: July 8, 2011Date of Patent: September 24, 2013Assignee: Leica Biosystems Nussloch GmbHInventors: Markus Berberich, Christian Wilke
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Publication number: 20130233071Abstract: The present invention relates to a coverslipping machine (1) including: a hollow needle (2) for applying mounting medium onto a specimen slide (5); a transparent container (103) to be filled with a liquid; a light source (101) for radiating measurement light in a principal radiating direction (A) into the container (103); and a light sensor (102, 102?) for detecting the measurement light, the light source (101) being arranged with respect to the container (103) in such a way that the radiated measurement light is refracted by a liquid in the container whose fill level exceeds a fill level limit, the light sensor (102, 102?) being arranged with respect to the container (103) in such a way that only measurement light refracted by the liquid or only measurement light not refracted by the liquid is detected.Type: ApplicationFiled: March 1, 2013Publication date: September 12, 2013Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Markus Berberich, Christian Wilke, Tobias Trump
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Patent number: 8524172Abstract: A sensor device (45) for calibrating a staining device (20) has a coupling unit (46) which is configured to be attachable to a transport device (22) of the staining device (20). A sensor unit (48) of the sensor device (45) is adapted to detect the presence of components of the staining device (20).Type: GrantFiled: July 8, 2011Date of Patent: September 3, 2013Assignee: Leica Biosystems Nussloch GmbHInventors: Markus Berberich, Christian Wilke
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Patent number: 8205906Abstract: The invention relates to a rehabilitation children's sport stroller, comprising a frame (28), a seat (10), and a pivot device (16), which at least in some regions connects the seat (10) to the frame (28) pivotally about a seat pivot axis (S) and comprises a first joint (20) and a second joint (22), which are provided on the seat (10) on mutually opposing sides, wherein the first joint (20) and the second joint (22) can be locked, the first joint (20) comprising a first-joint operating element (40) for releasing the first joint (20). According to the invention, the second joint (22) is connected to the first-joint operating element (40) by means of a push-stable transfer device such that during an actuation of the first-joint operating element (40) the first joint (20) and the second joint (22) are released.Type: GrantFiled: September 3, 2008Date of Patent: June 26, 2012Assignee: Otto Bock Healthcare GmbHInventors: Oliver Kretschmer, Christian Wilke, Jürgen Christmann
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Publication number: 20120148380Abstract: The invention relates to apparatuses for turning racks (1) for specimen slides (4), having a rack receptacle for at least one rack, the rack (1) being oriented in the rack receptacle horizontally in a first position such that specimen slides in the rack are arranged vertically next to one another relative to a longitudinal axis of the rack, and the rack receptacle being pivotable around a rotation axis (8) into a second position in which the rack (1) is oriented vertically. The rotation axis (8) of the rack (1) extends obliquely with respect to the longitudinal axis (5) of the horizontally oriented rack (1), so that the rack (1) can be pivoted back and forth between the first and the second position by means of a 180-degree rotation around the rotation axis (8).Type: ApplicationFiled: December 12, 2011Publication date: June 14, 2012Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBHInventor: Christian WILKE