Patents by Inventor Christian WITTE

Christian WITTE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4616086
    Abstract: The present invention is concerned with new carboxylic acid derivatives, with processes for the preparation thereof and with pharmaceutical compositions for lipid depression and thrombocyte aggregation, containing them, and to methods for treating infirmaties caused by excess lipids or thrombocyte aggregation.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: October 7, 1986
    Assignee: Boehringer Mannheim GmbH
    Inventors: Ernst-Christian Witte, Hans P. Wolff, Bernd Hagenbruch, Karlheinz Stegmeir, Johannes Pill
  • Patent number: 4443477
    Abstract: The invention provides sulphonamides of the formula ##STR1## wherein R is a hydrogen atom or a lower alkyl radical;R.sub.1 is alkyl, aryl, aralkyl or aralkenyl, the aryl moiety of which in each case can be optionally substituted one or more times by hydroxyl, halogen, trifluoromethyl, lower alkyl or alkoxy or by acyl, carboxy or alkoxycarbonyl;n is 1, 2 or 3; andW is a valence bond or a divalent aliphatic hydrocarbon linkageand the physiologically acceptable salts, esters and amides of such compound. These compounds have excellent pharmacological lipid depressing activity and inhibit thrombocyte aggregation.
    Type: Grant
    Filed: July 7, 1982
    Date of Patent: April 17, 1984
    Assignee: Boehringer Mannheim GmbH
    Inventors: Ernst-Christian Witte, Hans P. Wolfe, Karlheinz Stegmeier, Egon Roesch
  • Patent number: 4278680
    Abstract: Phenylacetic acid derivatives of the formula ##STR1## wherein A is an aryl radical optionally substituted by halogen, trifluoromethyl, alkyl, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino or aryloxy, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy,Y is a valency bond or an optionally branched alkylene radical containing up to 3 carbon atoms, andR.sub.1 and R.sub.2 each independently is hydrogen or a lower alkyl radical,or a physiologically compatible salt or ester thereof, exhibit marked hypoglycaemic and hypolipidaemic activity.
    Type: Grant
    Filed: December 10, 1979
    Date of Patent: July 14, 1981
    Assignee: Boehringer Mannheim GmbH
    Inventors: Manfred Hubner, Hans Kuhnle, Ernst-Christian Witte, Ruth Heerdt, Rudi Weyer, Volker Hitzel
  • Patent number: 4258058
    Abstract: Phenoxyalkylcarboxylic acid compounds of the formula ##STR1## wherein R is hydrogen or lower alkylR.sub.1 is alkyl or aryl, aralkyl or aralkenyl radical, the aryl moiety of which can be substituted one or more times by halogen, hydroxyl, trifluoromethyl or lower alkyl, alkoxy or acylR.sub.2 and R.sub.3 are individually selected from hydrogen or lower alkyl, andn is 0, 1, 2 or 3and the physiologically acceptable salts, esters and amides thereof; are outstandingly effective in inhibiting thrombocyte aggregation.
    Type: Grant
    Filed: February 26, 1979
    Date of Patent: March 24, 1981
    Assignee: Boehringer Mannheim GmbH
    Inventors: Ernst-Christian Witte, Hans P. Wolff, Max Thiel, Karlheinz Stegmeier, Egon Roesch
  • Patent number: 4207341
    Abstract: Phenylacetic acid derivatives of the formula ##STR1## wherein A is an aryl radical optionally substituted by halogen, trifluoromethyl, alkyl, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino or aryloxy, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy,Y is a valency bond or an optionally branched alkylene radical containing up to 3 carbon atoms, andR.sub.1 and R.sub.2 each independently is hydrogen or a lower alkyl radical,or a physiologically compatible salt or ester thereof, exhibit marked hypoglycaemic and hypolipidaemic activity.
    Type: Grant
    Filed: July 1, 1976
    Date of Patent: June 10, 1980
    Assignee: Boehringer-Mannheim GmbH
    Inventors: Manfred Hubner, Hans Kuhnle, Ernst-Christian Witte, Ruth Heerdt, Rudi Weyer, Volker Hitzel
  • Patent number: 4153728
    Abstract: Novel phenoxyalkylcarboxylic acid compounds of the formula ##STR1## wherein B is a valency bond or a straight-chained or branched, saturated or unsaturated hydrocarbon radical containing up to 3 carbon atoms;N is 1 or 2 andR.sub.1, r.sub.2 and R.sub.3 are hydrogen or lower alkyl; and the pharmacologically compatible salts thereof; have been found to be outstandingly effective in lowering the serum lipid level and the cholesterol level in mammals without inducing undesired side effects and to possess excellent thrombocyte-aggregation inhibiting activity.
    Type: Grant
    Filed: October 18, 1976
    Date of Patent: May 8, 1979
    Assignee: Boehringer Mannheim GmbH
    Inventors: Hans P. Wolff, Ernst-Christian Witte, Max Thiel, Harald Stork, Egon Roesch
  • Patent number: 4151303
    Abstract: Novel phenoxyalkylcarboxylic acid compounds of the formula ##STR1## wherein A is aryl, aryloxy, substituted aryl or substituted aryloxy, wherein the substituents are selected from lower alkyl, lower alkoxy, halogen and haloalkyl;B is a straight-chained or branched, saturated or unsaturated hydrocarbyl containing up to 5 carbon atoms;N is 1, 2 or 3 andR.sub.1, r.sub.2 and R.sub.3, which may be the same or different, are hydrogen or lower alkyl;And the pharmacologically compatible salts thereof; have been found to be outstandingly effective in depressing serum-lipid and triglycerides in the serum of mammals.
    Type: Grant
    Filed: September 1, 1976
    Date of Patent: April 24, 1979
    Assignee: Boehringer Mannheim GmbH
    Inventors: Ernst-Christian Witte, Hans P. Wolff, Kurt Stach, deceased, Wolfgang Schaumann, Karlheinz Stegmeier
  • Patent number: 3997666
    Abstract: New 1-[3-(naphth-1-yloxy)-2-hydroxypropyl]-piperazine compounds of the formula: ##STR1## and the pharmacologically compatible salts thereof are outstandingly effective in lowering blood pressure and are thus useful as anti-hypertensive agents.
    Type: Grant
    Filed: January 28, 1975
    Date of Patent: December 14, 1976
    Assignee: Boehringer Mannheim G.m.b.H.
    Inventors: Ernst-Christian Witte, Kurt Stach, Max Thiel, Gisbert Sponer, Egon Roesch
  • Patent number: 3997667
    Abstract: New 1-[3-naphth-1-yloxy)-propyl]-piperazine compounds of the formula: ##STR1## wherein X is hydrogen or methoxy;And the pharmacologically compatible salts thereof;Are outstandingly effective in lowering blood pressure and are thus useful as anti-hypertensive agents.
    Type: Grant
    Filed: January 28, 1975
    Date of Patent: December 14, 1976
    Assignee: Boehringer Mannheim G.m.b.H.
    Inventors: Ernst-Christian Witte, Kurt Stach, Max Thiel, Gisbert Sponer, Egon Roesch
  • Patent number: 3947446
    Abstract: 1-[3-(5,6,7,8-TETRAHYDRONAPHTH-1-YLOXY)-PROPYL]-PIPERAZINE DERIVATIVES OF THE FORMULA ##SPC1##WhereinA is hydrogen or hydroxyl;X is hydrogen or halogen or alkyl, alkoxy, alkylthio, trifluoromethyl, hydroxyl, nitro, amino, acylamino (i.e., alkanoylamino) or alkylsulfonylamino; andn is 0, 1 or 2;And the pharmacologically compatible salts thereof; exhibit outstanding blood pressure depressing activity, i.e., possess antihypertensive properties.
    Type: Grant
    Filed: June 14, 1973
    Date of Patent: March 30, 1976
    Assignee: Boehringer Mannheim GmbH
    Inventors: Ernst-Christian Witte, Kurt Stach, Karl Dietmann, Gisbert Sponer