Abstract: Described herein is an apparatus (a flexible pulsation sensor (FPS) device) that provides wireless monitoring capability. The FPS device includes a FPS configured to wrap around a measurement target of a conduit, such as a synthetic vascular graft or a vessel of a patient. The FPS device also includes a flexible circuit board fitting including circuit elements. The circuit elements can include a pressure sensor that collects data related to displacement of the FPS related to a pressure of and/or within the measurement target; and a wireless transmitter that transmits the data related to the pressure of and/or within the measurement target wirelessly to an external device.

Abstract: The present disclosure is directed to transparent, flexible substrates and, in particular, moisture-absorbing substrates for use in wound healing and wearable bioelectronics. Substrates of the present application can be formulated and used as wound dressings, electrodes, and electroceutical devices. Advantageously, in some aspects, substrates of the present application can absorb moisture (e.g., wound exudate, apocrine sweat, eccrine sweat), without swelling while also remaining transparent even with moisture absorption. In other aspects, substrates of the present application can be formulated to exhibit superior mechanical and electrical properties for application to a wide array of bioelectronic applications.

Abstract: A microfluidic pH-stat with a specially-is designed slide and portable device can be used for point-of-care enzyme diagnostics. The slide includes a microchamber and a substrate for the enzyme being tested. The substrate is homogenized with the sample in the microchamber to form a test volume. The microchamber includes a working microelectrode that injects current to split water in the test volume to generate hydrogen ions and/or hydroxide ions and a micro-pH-electrode to measure a pH of the test volume; the slide also includes a reference microelectrode. The device includes a processor to adjust the injected current based on the pH of the test volume and determine an activity of the enzyme based on an amount the injected current is adjusted.

Abstract: Provided are devices and methods for providing a flexible implantable tissue stimulator. A flexible implantable tissue stimulator can be use in a variety of medical/surgical procedures, and therapeutic interventions, such as musculoskeletal stimulation therapy. The flexible implantable tissue stimulator can be implanted via a minimally invasive procedure and comprises a biocompatible flexible construction that enables it to conform to a variety of implantation orientations and biological conditions. The flexible implantable tissue can provide programmable biphasic electrical stimulation to impaired tissue, such as a gluteal muscle.

Abstract: Provided are devices and methods for providing a flexible implantable tissue stimulator. A flexible implantable tissue stimulator can be use in a variety of medical/surgical procedures, and therapeutic interventions, such as musculoskeletal stimulation therapy. The flexible implantable tissue stimulator can be implanted via a minimally invasive procedure and comprises a biocompatible flexible construction that enables it to conform to a variety of implantation orientations and biological conditions. The flexible implantable tissue can provide programmable biphasic electrical stimulation to impaired tissue, such as a gluteal muscle.

Abstract: A microfluidic pH-stat with a specially-is designed slide and portable device can be used for point-of-care enzyme diagnostics. The slide includes a microchamber and a substrate for the enzyme being tested. The substrate is homogenized with the sample in the microchamber to form a test volume. The microchamber includes a working microelectrode that injects current to split water in the test volume to generate hydrogen ions and/or hydroxide ions and a micro-pH-electrode to measure a pH of the test volume; the slide also includes a reference microelectrode. The device includes a processor to adjust the injected current based on the pH of the test volume and determine an activity of the enzyme based on an amount the injected current is adjusted.

Abstract: One aspect of the present disclosure can include an interconnect system for bridging electrical contacts. The system can include a first electrical contact, a second electrical contact, and an interconnect device that is coupled to and extends between the first and second electrical contacts. The interconnect device can include a flexible bridge and a non-linear conductive transmission line. The flexible bridge can have a length and an outer surface. The non-linear conductive transmission line can extend along, and encircle at least a portion of, the length of the bridge such that the non-linear conductive transmission line electrically connects the first electrical contact with the second electrical contact.

Abstract: One aspect of the present disclosure can include an interconnect system for bridging electrical contacts. The system can include a first electrical contact, a second electrical contact, and an interconnect device that is coupled to and extends between the first and second electrical contacts. The interconnect device can include a flexible bridge and a non-linear conductive transmission line. The flexible bridge can have a length and an outer surface. The non-linear conductive transmission line can extend along, and encircle at least a portion of, the length of the bridge such that the non-linear conductive transmission line electrically connects the first electrical contact with the second electrical contact.

Abstract: A method of depositing a ceramic film, particularly a silicon carbide film, on a substrate is disclosed in which the residual stress, residual stress gradient, and resistivity are controlled. Also disclosed are substrates having a deposited film with these controlled properties and devices, particularly MEMS and NEMS devices, having substrates with films having these properties.