Patents by Inventor Christian Zwieb

Christian Zwieb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TGFß TYPE II-TYPE III RECEPTOR FUSIONS
    Publication number: 20170166624
    Abstract: Certain embodiments are directed to TGF-? inhibitors EUc and REUc. EUc is generated by removing the non-binding N-terminal subdomain from the TGF-? type III receptor, and REUc is generated by fusing together the binding domains of the TGF-? type II (RII or R) and type III receptor (RIII or EU) by a flexible linker and by removing the non-binding N-terminal subdomain from the TGF-? type III receptor.
    Type: Application
    Filed: July 14, 2015
    Publication date: June 15, 2017
    Inventors: Andrew Hinck, LuZhe Sun, Christian Zwieb
  • TGFB type II-type III receptor fusions
    Patent number: 9611306
    Abstract: Certain embodiments are directed to novel heterotrimeric fusions in which the ectodomain of the TGF-? type II receptor (T?P?II) is coupled to the N- and C-terminal ends of the endoglin-domain of the TGF-? type III receptor (TpRIIIE). Certain embodiments are directed to novel heterotrimeric polypeptides in which the ectodomain of the TGF-? type II receptor (TI3RII) is coupled to the N- and C-terminal ends of the endoglin-domain (E domain) of the TGF-? type III receptor (TI3RIII). This trimeric receptor, known as RER, can bind all three TGF-? isoforms with sub-nanomolar affinity and is effective at neutralizing signaling induced by all three TGF-? isoforms, but not other ligands of the TGF-? superfamily, such as activins, growth and differentiation factors (GDFs), and bone morphonogenetic proteins (BMPs).
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: April 4, 2017
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Andrew Hinck, Luzhe Sun, Christian Zwieb
  • TGFB TYPE II-TYPE III RECEPTOR FUSIONS
    Publication number: 20150045299
    Abstract: Certain embodiments are directed to novel heterotrimeric fusions in which the ectodomain of the TGF-? type II receptor (T?P?II) is coupled to the N- and C-terminal ends of the endoglin-domain of the TGF-? type III receptor (TpRIIIE). Certain embodiments are directed to novel heterotrimeric polypeptides in which the ectodomain of the TGF-? type II receptor (TI3RII) is coupled to the N- and C-terminal ends of the endoglin-domain (E domain) of the TGF-? type III receptor (TI3RIII). This trimeric receptor, known as RER, can bind all three TGF-? isoforms with sub-nanomolar affinity and is effective at neutralizing signaling induced by all three TGF-? isoforms, but not other ligands of the TGF-? superfamily, such as activins, growth and differentiation factors (GDFs), and bone morphonogenetic proteins (BMPs).
    Type: Application
    Filed: March 28, 2013
    Publication date: February 12, 2015
    Inventors: Hinck Andrew, Luzhen Sun, Christian Zwieb
  • TGFbeta type II-type III receptor fusions
    Patent number: RE49280
    Abstract: Certain embodiments are directed to novel heterotrimeric fusions in which the ectodomain of the TGF-? type II receptor (T?P?II) is coupled to the N- and C-terminal ends of the endoglin-domain of the TGF-? type III receptor (TpRIIIE). Certain embodiments are directed to novel heterotrimeric polypeptides in which the ectodomain of the TGF-? type II receptor (TI3RII) is coupled to the N- and C-terminal ends of the endoglin-domain (E domain) of the TGF-? type III receptor (TI3RIII). This trimeric receptor, known as RER, can bind all three TGF-? isoforms with sub-nanomolar affinity and is effective at neutralizing signaling induced by all three TGF-? isoforms, but not other ligands of the TGF-? superfamily, such as activins, growth and differentiation factors (GDFs), and bone morphonogenetic proteins (BMPs).
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: November 8, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Andrew Hinck, Luzhen Sun, Christian Zwieb