Patent number: 6777442
Abstract: The present invention relates to compounds of the general formula (I)
in which X represents O, S, SO, SO2, CH2, CHF, CF2 or NR8, and Z represents a group of the formula
in which A represents O or S, the subscript “a” is 0 or 1, group D represents a straight-chain (C1-C4)-alkylene group, and R36 represents OR37 or NR38R39. It also relates to processes for preparation of such compounds and to their use in medicaments for the treatment of depression, goiter, cancer of the thyroid gland, arteriosclerosis, hypercholesterolaemia, dyslipidaemia, obesity, cardiac insufficiency, pulmonary emphysema, pain, migraine, Alzheimer's disease, osteoporosis, cardiac arrhythmias, hypothyroidism, skin disorders or diabetes.
Type:
Grant
Filed:
February 26, 2002
Date of Patent:
August 17, 2004
Assignee:
Bayer Aktiengesellschaft
Inventors:
Helmut Haning, Michael Woltering, Gunter Schmidt, Christiane Faeste, Hilmar Bischoff, Axel Kretschmer, Verena Vöhringer, Peter Ellinghaus