Patents by Inventor Christina F. Spiropoulou

Christina F. Spiropoulou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS REPLICON PARTICLES AND USE THEREOF
    Publication number: 20220023410
    Abstract: Crimean-Congo hemorrhagic fever (CCHF) virus replicon particles (VRP) are described. These VRP are capable of undergoing a single round of virus replication, but are unable to produce new particles or spread to neighboring cells due to the lack of the glycoprotein-encoding M genome segment. In some instances, the VRP contain one or more mutations in the viral ovarian tumor domain protease encoded by the L genome segment or heterologous antigens within its S genome segment. The VRP are shown to elicit a protective immune response against lethal CCHF virus challenge in an animal model.
    Type: Application
    Filed: December 13, 2019
    Publication date: January 27, 2022
    Applicants: University of Georgia Research Foundation, Inc., THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Eric Bergeron, Scott D. Pegan, Stephen R. Welch, Florine E.M. Scholte, Christina F. Spiropoulou, Stuart T. Nichol, Jessica R. Spengler
  • Polypeptides of a novel hantavirus
    Patent number: 6620913
    Abstract: The present invention relates to the discovery of a novel Hantavirus. In particular, the present invention relates to nucleic acids of the newly discovered virus and to nucleic acid reagents and antibodies for use in methods of detection and prevention of infection by the virus.
    Type: Grant
    Filed: April 18, 2002
    Date of Patent: September 16, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Stuart T. Nichol, Christina F. Spiropoulou, Thomas G. Ksiazek, Pierre E. Rollin
  • Strain of hantavirus nucleotide sequences thereof related probes, primers and vectors, and methods for detection
    Patent number: 5945277
    Abstract: The present invention relates to the discovery of a novel Hantavirus. In particular, the present invention relates to nucleic acids of the newly discovered virus and to nucleic acid reagents and antibodies for use in methods of detection and prevention of infection by the virus.
    Type: Grant
    Filed: May 30, 1996
    Date of Patent: August 31, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Stuart T. Nichol, Christina F. Spiropoulou, Thomas G. Ksiazek, Pierre E. Rollin
  • Bayou hantavirus and related methods
    Patent number: 5916754
    Abstract: The present invention relates to the discovery and isolation of a novel hantavirus designated the Bayou hantavirus. In particular, the present invention relates to nucleic acids of the newly discovered virus and to nucleic acid reagents (primers and probes), purified polypeptides and antibodies for use in methods of detection and prevention of infection by the virus. A vaccine or purified immunogenic polypeptide of the Bayou hantavirus in a pharmaceutically acceptable carrier is provided. A vector comprising the nucleic acids of the invention is provided. A method of detecting the presence of a hantavirus in a subject comprising contacting an antibody-containing sample from the subject with a purified polypeptide of the invention and detecting the reaction of the polypeptide and the antibody is provided.
    Type: Grant
    Filed: February 17, 1995
    Date of Patent: June 29, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Stuart T. Nichol, Sergey Morzunov, Thomas G. Ksiazek, Pierre E. Rollin, Christina F. Spiropoulou