Abstract: The human Interleukin 1 Receptor antagonist anakinra can be used in the treatment of pancreatic ductal adenocarcinoma (PDAC). The treatment involves administration of a daily dose of approximately at least 200 mg of anakinra to a patient in need thereof, for example to a patient who is undergoing a chemotherapy treatment regimen. The anakinra can be used in related treatment methods and corresponding pharmaceutical compositions.

Abstract: The invention relates to bispyranilidenes, dithiobispyranilidenes and diselenobispyranilidene according to formula (I), to the use thereof as light or IR-absorber and to an electronic or optoelectronic component containing at least one compound according to formula (I).

Abstract: This disclosure provides a method, apparatus and computer-readable storage medium for visual teaching. The visual teaching method includes establishing a classroom, arranging the classroom based on the real geometric layout of at least one teaching device in the classroom, and conducting the course in the classroom based on the arranged classroom, wherein the classroom comprises at least one user smart terminal, at least one teaching device and at least one of a management smart terminal and a server, at least one teaching device and/or at least one user smart terminal being communicatively connected to at least one of the management smart terminal and the server operating the classroom, each of the user smart terminals operating at least one corresponding teaching device and obtaining the status of the corresponding teaching devices. The visual teaching solution provides a course-oriented and student-oriented visual teaching environment by combining the courses, teaching devices and students.

Abstract: This disclosure provides a method, apparatus and computer-readable storage medium for visual teaching. The visual teaching method includes establishing a classroom, arranging the classroom based on the real geometric layout of at least one teaching device in the classroom, and conducting the course in the classroom based on the arranged classroom, wherein the classroom comprises at least one user smart terminal, at least one teaching device and at least one of a management smart terminal and a server, at least one teaching device and/or at least one user smart terminal being communicatively connected to at least one of the management smart terminal and the server operating the classroom, each of the user smart terminals operating at least one corresponding teaching device and obtaining the status of the corresponding teaching devices. The visual teaching solution provides a course-oriented and student-oriented visual teaching environment by combining the courses, teaching devices and students.

Abstract: The present invention relates to methods for identifying agents useful for alleviating insulin resistance in mammals, said methods being enabled by the finding that the insulin receptor substrate 1 (IRS-1) and histone deacetylase 2 (HDAC2) physically interact. By inhibition of the deacetylase activity in this complex, the insulin sensitivity can be restored.