Abstract: The present invention relates to combination therapies employing 4-1BB (CD137) agonists, in particular 4-1BBL trimer containing antigen binding molecules, in combination with HER-2 targeting agents, the use of these combination therapies for the treatment of cancer, and methods of using the combination therapies.

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) at least one moiety capable of specific binding to a costimulatory TNF receptor family member, and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

Abstract: The invention relates to Her2 targeting 4-1BB agonists, in particular 4-1BBL trimer-containing antigen binding molecules comprising at least one antigen binding domain capable of specific binding to Her2 and their use in the treatment of cancer as well as their use in combination with T-cell activating anti-CD3 bispecific antibodies.

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) a polypeptide comprising three ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by peptide linkers and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

Abstract: The present invention relates to a granulating and/or agglomerating tool for a granulating and/or agglomerating device with a fastening shaft and a substantially disk-shaped element with a diameter d which is fastened thereto and has an upper surface, a lower surface and a circumferential surface connecting the upper and the lower surface. In order to provide a granulating and/or agglomerating tool for a granulating and/or agglomerating device and a corresponding granulating and/or agglomerating device and a method for granulating or agglomerating with which the desired granulating or agglomerating result can be obtained very much faster and above all with a significantly finer granulated material with a significantly higher yield in the range of from 0.1 to 0.8 mm, it is proposed according to the invention that the circumferential surface exhibits a plurality of essentially V-shaped grooves running parallel to the axis of the shaft.

Abstract: The present invention relates to a granulating and/or agglomerating tool for a granulating and/or agglomerating device with a fastening shaft and a substantially disk-shaped element with a diameter d which is fastened thereto and has an upper surface, a lower surface and a circumferential surface connecting the upper and the lower surface. In order to provide a granulating and/or agglomerating tool for a granulating and/or agglomerating device and a corresponding granulating and/or agglomerating device and a method for granulating or agglomerating with which the desired granulating or agglomerating result can be obtained very much faster and above all with a significantly finer granulated material with a significantly higher yield in the range of from 0.1 to 0.8 mm, it is proposed according to the invention that the circumferential surface exhibits a plurality of essentially V-shaped grooves running parallel to the axis of the shaft.

Abstract: The invention relates to a laminate that has at least two layers, in which at least one layer of the laminate is a water-soluble polymer film containing active substances (=“water-soluble polymer film containing active substances”), the polymer forming the film is a water-soluble polymer, and at least one second layer of the laminate is a nonwoven fabric, knitted fabric, woven fabric or a foam film (=“water retention layer”) consisting of a water-soluble polymer. The water-soluble polymers of the two layers are identical or different. The invention further relates to the production of such a laminate and to the use thereof.

Abstract: The subject matter of the present invention is a hydrogel which includes a combination of at least four polysaccharides. These polysaccharides are those which are in the natural state and which are not produced, altered or modified by chemical reactions. The combination of konjac mannan, xanthan gum, pullulan and carrageenan and optionally sclerotium gum produces, within certain concentration ranges, a stable, slightly sticky, neutral smelling, flexible and transparent hydrogel which can be used as a cosmetic product for skin care.

Abstract: An article is disclosed which constitutes a multilayered plaster for application to the skin. It comprises an adhesive layer (1), a printed carrier layer (2), a coating layer (3) comprising at least one fragrance and a removable protective layer (4). In one particular embodiment, the fragrance is contained in microcapsules.