Patents by Inventor Christina L. Pier

Christina L. Pier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hybrid neurotoxins and uses thereof
    Patent number: 10688162
    Abstract: The present disclosure relates to chimeric neurotoxins and uses thereof. In particular, provided herein are chimeric botulinum neurotoxins with altered properties and uses thereof (e.g., research, screening, and therapeutic uses).
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: June 23, 2020
    Assignee: CELLSNAP LLC
    Inventors: Eric A. Johnson, Sabine Pellett, William H. Tepp, Marite Bradshaw, Christina L. Pier, Joseph T. Barbieri
  • HYBRID NEUROTOXINS AND USES THEREOF
    Publication number: 20180193435
    Abstract: The present disclosure relates to chimeric neurotoxins and uses thereof. In particular, provided herein are chimeric botulinum neurotoxins with altered properties and uses thereof (e.g., research, screening, and therapeutic uses).
    Type: Application
    Filed: January 10, 2018
    Publication date: July 12, 2018
    Inventors: Eric A. Johnson, Sabine Pellett, William H. Tepp, Marite Bradshaw, Christina L. Pier, Joseph T. Barbieri
  • -derived vaccine and therapy against botulism
    Patent number: 7820411
    Abstract: A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an expression vector comprising DNA encoding HCR protein, (b) inducing expression of the HCR protein at a reduced temperature in a culture media, and (c) purifying the HCR protein via extraction, wherein the extraction comprises a clarification by centrifugation and a filtration, wherein the purified HCR protein is at least 10 mg/L of culture medium.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: October 26, 2010
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Michael Baldwin, Marite Bradshaw, William H. Tepp, Eric A. Johnson, Joseph T. Barbieri, Christina L. Pier
  • ESCHERICHIA COLI-DERIVED VACCINE AND THERAPY AGAINST BOTULISM
    Publication number: 20090017495
    Abstract: A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an expression vector comprising DNA encoding HCR protein, (b) inducing expression of the HCR protein at a reduced temperature in a culture media, and (c) purifying the HCR protein via extraction, wherein the extraction comprises a clarification by centrifugation and a filtration, wherein the purified HCR protein is at least 10 mg/L of culture medium.
    Type: Application
    Filed: February 29, 2008
    Publication date: January 15, 2009
    Inventors: Michael Baldwin, Eric A. Johnson, Joseph T. Barbieri, Marite Bradshaw, William H. Tepp, Christina L. Pier