Patents by Inventor Christina M. Grozinger

Christina M. Grozinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Class II human histone deacetylases, and uses related thereto
    Patent number: 8895284
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: November 25, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber
  • CLASS II HUMAN HISTONE DEACETYLASES, AND USES RELATED THERETO
    Publication number: 20130338024
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Application
    Filed: May 7, 2013
    Publication date: December 19, 2013
    Applicant: President and Fellows of Harvard College
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber
  • Class II human histone deacetylases, and uses related thereto
    Patent number: 8435780
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: May 7, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber
  • Dioxanes and uses thereof
    Patent number: 8178579
    Abstract: In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2, R3, n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e.g., cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p. The present invention also provides methods for preparing compounds of the invention.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: May 15, 2012
    Assignee: President and Fellows of Harvard College
    Inventors: Stuart L. Schreiber, Scott M. Sternson, Jason C. Wong, Christina M. Grozinger, Stephen J. Haggarty, Kathryn M. Koeller
  • CLASS II HUMAN HISTONE DEACETYLASES, AND USES RELATED THERETO
    Publication number: 20120094862
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Application
    Filed: December 13, 2011
    Publication date: April 19, 2012
    Applicant: President and Fellows of Harvard College
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber
  • Nucleic acids encoding class II human histone deacetylases, and uses related thereto
    Patent number: 8076116
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: December 13, 2011
    Assignee: President and Fellows of Harvard College
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber
  • Class II Human Histone Deacetylases, and Uses Related Thereto
    Publication number: 20090305384
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Application
    Filed: February 12, 2009
    Publication date: December 10, 2009
    Applicant: President and Fellows of Harvard College
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber
  • Class II Human Histone Deacteylases, and Uses Related Thereto
    Publication number: 20090036318
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Application
    Filed: July 31, 2007
    Publication date: February 5, 2009
    Applicant: President and Fellows of Harvard College
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber
  • Dioxanes and uses thereof
    Publication number: 20080269245
    Abstract: In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2, R3, n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e.g., cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p. The present invention also provides methods for preparing compounds of the invention.
    Type: Application
    Filed: July 17, 2007
    Publication date: October 30, 2008
    Inventors: Stuart L. Schreiber, Scott M. Sternson, Jason C. Wong, Christina M. Grozinger, Stephen J. Haggarty, Kathryn M. Koeller
  • Class II human histone deacetylases, and uses related thereto
    Patent number: 7250504
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: July 31, 2007
    Assignee: President and Fellows of Harvard College
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber
  • Dioxanes and uses thereof
    Patent number: 7244853
    Abstract: In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2, R3, n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e.g., cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p. The present invention also provides methods for preparing compounds of the invention.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: July 17, 2007
    Assignee: President and Fellows of Harvard College
    Inventors: Stuart L. Schreiber, Scott M. Sternson, Jason C. Wong, Christina M. Grozinger, Stephen J. Haggarty, Kathryn M. Koeller
  • Dioxanes and uses thereof
    Publication number: 20040072849
    Abstract: In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): 1
    Type: Application
    Filed: July 17, 2003
    Publication date: April 15, 2004
    Inventors: Stuart L. Schreiber, Scott M. Sternson, Jason C. Wong, Christina M. Grozinger, Stephen J. Haggarty, Kathryn M. Koeller
  • Dioxanes and uses thereof
    Publication number: 20030187027
    Abstract: In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): 1
    Type: Application
    Filed: May 9, 2002
    Publication date: October 2, 2003
    Inventors: Stuart L. Schreiber, Scott M. Sternson, Jason C. Wong, Christina M. Grozinger
  • Class II human histone deacetylases, and uses related thereto
    Publication number: 20030129724
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Application
    Filed: March 5, 2001
    Publication date: July 10, 2003
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber