Patents by Inventor Christina M. Parker

Christina M. Parker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel integrin alpha subunit
    Publication number: 20030133933
    Abstract: The present invention relates to a novel integrin &agr;E subunit and its functional equivalents. The invention further includes pharmaceutical compositions containing the isolated peptides, oligonucleotides encoding the peptides, vectors containing the oligonucleotides, and cell lines transfected with the vectors.
    Type: Application
    Filed: June 21, 2002
    Publication date: July 17, 2003
    Inventors: Michael B. Brenner, Christina M. Parker
  • Control of lymphocyte localization by LEEP-CAM activity
    Publication number: 20030049259
    Abstract: A novel cell surface glycoprotein, LEEP-CAM, is disclosed. This invention further provides methods for treating inflammatory disorders in mammals through the administration of compositions which are modulators of LEEP-CAM activity. Antibodies are also disclosed which prevent LEEP-CAM-mediated migration of lymphocytes into epithelial layers of cells.
    Type: Application
    Filed: January 22, 2002
    Publication date: March 13, 2003
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Michael B. Brenner, Christina M. Parker, Michael P. Schon
  • Method of treating ulcerative colitis or crohn's disease by administering an antibody to&agr;E&bgr;7 integrin
    Patent number: 6455042
    Abstract: The present invention relates to a method for treating an autoimmune disease, such ulcerative coliteis or crohns disease characterized by lymphocyte accumulation at epithelial sites. The method involves administering to a subject an effective amount of an antibody that selectively binds to an &agr;E&bgr;7 integrin or an &agr;E subunit thereof.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: September 24, 2002
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Michael B. Brenner, Christina M. Parker
  • Antibodies to integrin alpha subunit
    Patent number: 6063906
    Abstract: The present invention relates to antibodies that bind to a highly charged region of the integrin .alpha..sup.E subunit and its functional equivalents. The antibodies are useful in screening assays to identify agents which mimic the ligand-binding site on the integrin .alpha..sup.E.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: May 16, 2000
    Assignee: Brigham and Women's Hospital, Inc.
    Inventors: Michael B. Brenner, Christina M. Parker
  • Integrin alpha subunit
    Patent number: 6057423
    Abstract: The present invention relates to a novel integrin .alpha..sup.E subunit and its functional equivalents. The method for screening a molecular library to identify lead compounds which mimick the in vivo activity of an integrin .alpha..sup.E chain is disclosed. The invention further includes pharmaceutical compositions containing the isolated peptides, oligonucleotides encoding the peptides, vectors containing the oligonucleotides, and cell lines transfected with the vectors.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: May 2, 2000
    Assignee: Brigham & Women's Hospital, Inc.
    Inventors: Michael B. Brenner, Christina M. Parker
  • Mouse model of psoriasis
    Patent number: 5945576
    Abstract: Methods and compositions for preparing a mouse model of an inflammatory skin condition are disclosed. The methods involve administering donor lymphocytes to a recipient immune deficient mouse to induce the inflammatory skin response. The mouse models are useful for testing the efficacy of a therapeutic agent for treating the inflammatory skin condition. In particular, the mouse models are useful for screening therapeutic agents for treating human psoriasis.
    Type: Grant
    Filed: April 5, 1996
    Date of Patent: August 31, 1999
    Assignee: Brigham & Women's Hospital, Inc.
    Inventors: Christina M. Parker, Michael P. Schon
  • Integrin alpha subunit
    Patent number: 5594120
    Abstract: The present invention relates to a novel integrin .alpha..sup.E subunit and its functional equivalents. The invention further includes pharmaceutical compositions containing the isolated peptides, oligonucleotides encoding the peptides, vectors containing the oligonucleotides, and cell lines transfected with the vectors.
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: January 14, 1997
    Assignee: Brigham and Women's Hospital, Inc.
    Inventors: Michael B. Brenner, Christina M. Parker