Patents by Inventor Christina Magkoufopoulou

Christina Magkoufopoulou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vitro method for predicting in vivo genotoxicity of chemical compounds
    Patent number: 9822414
    Abstract: The invention is in the field of genomics and it provides an in vitro method for predicting whether a compound is genotoxic in vivo. In particular, the invention provides a method for predicting the in vivo genotoxicity of a compound comprising the steps of performing an Ames test on the compound and determining if the result is positive or negative, followed by a step wherein the gene expression of at least 3 genes is determined in a HepG2 cell, compared to a reference value and predicting that the compound is in vivo genotoxic if the expression level of more than 2 of the genes is above a reference value.
    Type: Grant
    Filed: May 19, 2012
    Date of Patent: November 21, 2017
    Assignees: UNIVERSITEIT MAASTRICHT, ACADEMISCH ZIEKENHUIS MAASTRICHT
    Inventors: Joseph Henri Marie Van Delft, Joseph Catharina Stephanus Kleinjans, Christina Magkoufopoulou, Danyel Gerardus Jacobus Jennen