Abstract: Provided herein are compounds of formula (I): and pharmaceutically-acceptable salts thereof, where A, W, X, Y and Z are defined in the specification. The compounds of formula (I) and pharmaceutically-acceptable salts thereof are Janus kinase (JAK) inhibitors. Also provided herein are pharmaceutical compositions comprising such compounds; and methods of using such compounds to treat, e.g., inflammatory and fibrotic diseases, including respiratory diseases.

Abstract: A method for automated risk management may include presenting a rule request graphical user interface (GUI) for a requester to enter information related to a rule request for a rule. The method may also include determining a risk rating score for the rule based on information entered in the rule request GUI. The information may include at least one of source information, destination information, service information and port information.

Abstract: A method for automated risk management may include presenting a rule request graphical user interface (GUI) for a requester to enter information related to a rule request for a rule. The method may also include determining a risk rating score for the rule based on information entered in the rule request GUI. The information may include at least one of source information, destination information, service information and port information.

Abstract: A tractor includes a cab mounted analysis/display unit (1) connected to a number of on-board sensors for detecting speed, fuel flow, etc and also capable of receiving data input manually or via a data carrier. The unit (1) is also connected to an on-board GPS navigation system (24), and includes means for generating maps of tractor-related parameters and/or parameters derived therefrom. The math usefulness of the system is in derby “on the go” maps of cost related data for a given field operation. Cost maps for cumulative operations and maps of gross profit margin are possible by adding “on the go” generated cost data to previously generated cost and/or yield data as the tractor performs an operation in a field.

Abstract: A tractor includes a cab mounted analysis/display unit (1) connected to a number of on-board sensors for detecting speed, fuel flow, etc and also capable of receiving data input manually or via a data carrier. The unit (1) is also connected to an on-board GPS navigation system (24), and includes means for generating maps of tractor-related parameters and/or parameters derived therefrom. The math usefulness of the system is in derby “on the go” maps of cost related data for a given field operation. Cost maps for cumulative operations and maps of gross profit margin are possible by adding “on the go” generated cost data to previously generated cost and/or yield data as the tractor performs an operation in a field.

Abstract: A tractor includes a cab mounted analysis/display unit (1) connected to a number of on-board sensors for detecting speed, fuel flow, etc and also capable of receiving data input manually or via a data carrier. The unit (1) is also connected to an on-board GPS navigation system (24), and includes means for generating maps of tractor-related parameters and/or parameters derived therefrom. The main usefulness of the system is in deriving “on the go” maps of cost related data for a given field operation. Cost maps for cumulative operations and maps of gross profit margin are possible by adding “on the go” generated cost data to previously generated cost and/or yield data as the tractor performs an operation in a field.