Patents by Inventor Christine A. Iacobuzio-Donahue

Christine A. Iacobuzio-Donahue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LARGE-SCALE EPIGENOMIC REPROGRAMMING LINKS ANABOLIC GLUCOSE METABOLISM TO DISTANT METASTASIS DURING THE EVOLUTION OF PANCREATIC CANCER PROGRESSION
    Publication number: 20240011100
    Abstract: The present invention relates to a method of identifying epigenetic reprogramming. Identifying epigenetic reprogramming comprises detecting large organized heterochromatin lysine (K)-9 modified domains (LOCKs) and large DNA hypomethylated blocks in a sample containing DNA from a subject having cancer, for example, PDAC.
    Type: Application
    Filed: August 1, 2023
    Publication date: January 11, 2024
    Inventors: Oliver McDonald, Xin Li, Christine A. Iacobuzio-Donahue, Andrew P. Feinberg
  • Identification of epigenomic reprogramming in cancer and uses thereof
    Patent number: 11795510
    Abstract: The present invention relates to a method of identifying epigenetic reprogramming. Identifying epigenetic reprogramming comprises detecting large organized heterochromatin lysine (K)-9 modified domains (LOCKs) and large DNA hypomethylated blocks in a sample containing DNA from a subject having cancer, for example, PDAC.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: October 24, 2023
    Assignees: The Johns Hopkins University, Memorial Sloan Kettering Cancer Center, Vanderbilt University
    Inventors: Oliver McDonald, Xin Li, Christine A. Iacobuzio-Donahue, Andrew P. Feinberg
  • LARGE-SCALE EPIGENOMIC REPROGRAMMING LINKS ANABOLIC GLUCOSE METABOLISM TO DISTANT METASTASIS DURING THE EVOLUTION OF PANCREATIC CANCER PROGRESSION
    Publication number: 20190233903
    Abstract: The present invention relates to a method of identifying targets for epigenetic reprogramming comprising detecting large organized heterochromatin lysine (K)-9 modified domains (LOCKs) and large DNA hypomethylated blocks in a sample containing DNA from a subject having cancer, for example, PDAC. The invention also provides for the use of differentially expressed genes to identify metastatic propensity in primary tumors, wherein the genes are selected from genes in the Tables herein, oxidative stress genes, EMT genes, immunological response genes, DNA repair genes, glucose metabolism genes, oxPPP genes, and PGD genes. Further, the invention provides a method for identifying agents or compounds to affect epigenomic changes, including inhibition of oxPPP comprising analyzing a sample from a subject before and after contacting with the agent or compound and determining the effect of the agent or compound on the epigenomic changes.
    Type: Application
    Filed: October 5, 2017
    Publication date: August 1, 2019
    Inventors: Oliver McDonald, Xin Li, Christine A. Iacobuzio-Donahue, Andrew P. Feinberg
  • METHODS OF SCREENING FOR CELL PROLIFERATION OR NEOPLASTIC DISORDERS
    Publication number: 20150309026
    Abstract: The invention relates to methods and compositions for identifying subjects having, or predisposed to having, a neoplastic or cell proliferation or neoplastic disorder. The methods are applicable to any type of tissue sample and can be conducted on otherwise normal tissue.
    Type: Application
    Filed: July 14, 2015
    Publication date: October 29, 2015
    Inventors: Andrew P. Feinberg, Christine A. Iacobuzio-Donahue, Dan L. Longo, Minoru Ko
  • Methods of screening for cell proliferation or neoplastic disorders
    Patent number: 9086403
    Abstract: The invention relates to methods and compositions for identifying subjects having, or predisposed to having, a neoplastic or cell proliferation or neoplastic disorder. The methods are applicable to any type of tissue sample and can be conducted on otherwise normal tissue.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: July 21, 2015
    Assignees: The Johns Hopkins University, National Institutes of Health
    Inventors: Andrew P. Feinberg, Christine A. Iacobuzio-Donahue, Dan L. Longo, Minoru Ko
  • Methods of screening for cell proliferation or neoplastic disorders
    Publication number: 20060003359
    Abstract: The invention relates to methods and compositions for identifying subjects having, or predisposed to having, a neoplastic or cell proliferation or neoplastic disorder. The methods are applicable to any type of tissue sample and can be conducted on otherwise normal tissue.
    Type: Application
    Filed: June 3, 2005
    Publication date: January 5, 2006
    Applicants: THE JOHNS HOPKINS UNIVERSITY, NATIONAL INSTITUTES OF HEALTH
    Inventors: Andrew Feinberg, Christine Iacobuzio-Donahue, Dan Longo, Minoru Ko
  • Pancreatic cancer diagnosis and therapies
    Publication number: 20030180747
    Abstract: The present invention includes methods and systems for identification (diagnosis) of abnormal cell growth by analysis of a patient sample, particularly the presence of a pancreatic cancer or susceptibility to a pancreatic cancer. The invention also includes therapeutic agents for treating pancreatic cancers as well as methods for identifying candidate agents for treatment of pancreatic cancers.
    Type: Application
    Filed: October 11, 2002
    Publication date: September 25, 2003
    Inventors: Ralph H. Hruban, Pedram Argani, Christine A. Iacobuzio-Donahue, Anirban Maitra