Abstract: The present invention relates to a recombinant bacterium that is capable of eliciting an immune response against at least two enteric pathogens, without substantially inducing an immune response specific to the serotype of the bacterium. The invention also relates to methods of making such a bacterium and vaccines and methods of using such a bacterium.

Abstract: The present invention relates to a recombinant bacterium that is capable of eliciting an immune response against at least two enteric pathogens, without substantially inducing an immune response specific to the serotype of the bacterium. The invention also relates to methods of making such a bacterium and vaccines and methods of using such a bacterium.

Abstract: The present invention provides a compound chosen from: a peptide represented by the sequence SEQ ID No: 1 below: SEQ ID No: 1 Lys-Ala-Lys-Pro-Val-Gln-Lys-Leu-Asp-Asp-Asp-Asp-Asp-Gly-Asp-Asp-Thr-Tyr-Lys-Glu-Glu-Arg-His-Asn-Lys and homologs of this peptide exhibiting at least 80% similarity with the sequence SEQ ID No: 1 and comprising from 20 to 30 amino acids. These compounds are useful in preventing, diagnosing and treating animal and/or human leptospirosis.

Abstract: Compounds (I) that are the peptide of sequence (1), its homologs with at least 60% homology, or their salts, functional fragments, chemical analogs and chemical derivatives, are new. Compounds (I) that are the peptide of sequence (1), its homologs with at least 60% homology, and their salts, functional fragments, chemical analogs and chemical derivatives are new. Chemical analogs have one or more amino acids (aa) replaced by the D-enantiomer or a non-natural aa or one or more peptide bonds replaced by isosteres such as CH2NH, CH2S, CH2CH2, CH?CH, COCH2, CH(OH)CH2 or CH2SO. Chemical derivatives are des-alpha amino peptides; N-alpha-acyl substituted by RCO; derivatives substituted at C-terminal carboxy by amino, OR, SR or NHR; derivatives containing a pharmacophore, and polymers of the peptides. R=1-50C alkyl, alkenyl, alkynyl, aryl or cyclic group.

Abstract: The invention concerns the identification of a leptospire protein, polypeptides and antibodies, and their uses for prevention, diagnosis, therapy or experimentation. The invention concerns in particular the isolation, cloning and characterisation of a protein or fragments thereof, containing immunogenic epitopes against leptospiral serovar, in particular pathogenic liptospires. Said protein, polypeptides or peptides derived therefrom, and the corresponding antibodies are particularly useful for preventing, screening or detecting the presence of leptospires in biological samples, for diagnosing leptospirosis, or for treating said pathologies, in human and animal subjects.